Articles

1. Dissolution Profiles of Immediate Release Products of Various Drugs in Biorelevant Bicarbonate Buffer: Comparison with Compendial Phosphate Buffer

   • Nanami Okamoto
   • Masaki Higashino
   • Kiyohiko Sugano

   Original Research Article Open access 23 April 2024

   

2. Assessment of Tunable Resistive Pulse Sensing (TRPS) Technology for Particle Size Distribution in Vaccine Formulations – A Comparative Study with Dynamic Light Scattering

   • Rahul Misra
   • Ginny Fung
   • Marina Kirkitadze

   Original Research Article 22 April 2024

   

3. Selective Delivery of Clindamycin Using a Combination of Bacterially Sensitive Microparticle and Separable Effervescent Microarray Patch on Bacteria Causing Diabetic Foot Infection

   • Nurul Fauziah
   • Nur Annisa Safirah
   • Andi Dian Permana

   Original Research Article 18 April 2024

   

4. Antimicrobial Activity Classification of Imidazolium Derivatives Predicted by Artificial Neural Networks

   • Andżelika Lorenc
   • Anna Badura
   • Adam Buciński

   Original Research Article Open access 17 April 2024

   

5. Machine Learning Exploration of the Relationship Between Drugs and the Blood–Brain Barrier: Guiding Molecular Modification

   • Qi Yang
   • Lili Fan
   • Zhengcai Du

   Original Research Article 11 April 2024

   

6. A Refined Thin-Film Model for Drug Dissolution Considering Radial Diffusion – Simulating Powder Dissolution

   • Karthik Salish
   • Chi So
   • Chen Mao

   Original Research Article 08 April 2024

   

7. Development and Validation of Matrix of Chemistry, Manufacturing, and Control (MoCMC) System for Intramammary Drug Products (IMM)

   • Nada A. Helal
   • Marilyn N. Martinez
   • Mansoor A. Khan

   Original Research Article 01 April 2024

   

8. Antibiotic Development: Lessons from the Past and Future Opportunities

   • Michael S. Kinch
   • Zachary Kraft
   • Tyler Schwartz

   Review Article 01 April 2024

   

9. Combating Alcohol Adduct Impurity in Immunosuppressant Drug Product Manufacturing: A Scientific Investigation for Enhanced Process Control

   • Vasanthakumar Sekar
   • Devarajan Vedhachalam
   • Jean-Marie M. Geoffroy

   Original Research Article 01 April 2024

   

10. Quantification of Unencapsulated Drug in Target Tissues Demonstrates Pharmacological Properties and Therapeutic Effects of Liposomal Topotecan (FF-10850)

    • Toshifumi Kimura
    • Ken Okada
    • Susumu Shimoyama

    Original Research Article Open access 27 March 2024 Pages: 795 - 806

    

11. Pharmacokinetics of PEGasparaginase in Infants with Acute Lymphoblastic Leukemia

    • Leiah J. Brigitha
    • Veerle Mondelaers
    • Inge M. van der Sluis

    Original Research Article 27 March 2024 Pages: 711 - 720

    

12. The Use of Global Sensitivity Analysis to Assess the Oral Absorption of Weakly Basic Compounds: A Case Example of Dipyridamole

    • Siddharth S. Kesharwani
    • Guillaume Louit
    • Fady Ibrahim

    Original Research Article 27 March 2024

    

13. Identification of Surfactant Impact on a Monoclonal Antibody Characterization via HPLC-Separation Based and Biophysical Methods

    • Kaizhu Guo
    • Jing Song
    • Rico C. Gunawan

    Original Research Article 22 March 2024 Pages: 779 - 793

    

14. Predicting Drug-Drug Interactions Involving Rifampicin Using a Semi-mechanistic Hepatic Compartmental Model

    • Jingxi Li
    • Xue Li
    • Bo Liu

    Original Research Article 22 March 2024 Pages: 699 - 709

    

15. Evaluation of Pharmacokinetic and Pharmacodynamic (PK/PD) of Novel Fluorenylmethoxycarbonyl- Phenylalanine Antimicrobial Agent

    • Avinash Y. Gahane
    • Devesh Pratap Verma
    • Ashwani K. Thakur

    Original Research Article 22 March 2024 Pages: 687 - 698

    

16. A High Threshold of Biotherapeutic Aggregate Numbers is Needed to Induce an Immunogenic Response In Vitro, In Vivo, and in the Clinic

    • Joseph R. Cohen
    • Stephen R. Brych
    • Marisa K. Joubert

    Original Research Article 22 March 2024 Pages: 651 - 672

    

17. Pharmacokinetic Profile of Brepocitinib with Topical Administration in Atopic Dermatitis and Psoriasis Populations: Strategy to Inform Clinical Trial Design in Adult and Pediatric Populations

    • Farzaneh Maleki
    • Cheng Chang
    • Timothy Nicholas

    Original Research Article Open access 22 March 2024 Pages: 623 - 636

    

18. Nonlinear Pharmacokinetics of Topical Flurbiprofen Gel in a Phase I Study Among Chinese Healthy Adults

    • Wending Xiao
    • Zhihong Zhu
    • Zeneng Cheng

    Original Research Article 20 March 2024

    

19. Peptide Acylation in Aliphatic Polyesters: a Review of Mechanisms and Inhibition Strategies

    • Mojgan Sheikhi
    • Nasrin Nemayandeh
    • Mehrnoosh Shirangi

    Review Article 19 March 2024 Pages: 765 - 778

    

20. Conversion of Olmesartan to Olmesartan Medoxomil, A Prodrug that Improves Intestinal Absorption, Confers Substrate Recognition by OATP2B1

    • Naomi Fukazawa
    • Tomohiro Nishimura
    • Masatoshi Tomi

    Original Research Article 14 March 2024

    

21. Importance of Considering Fed-State Gastrointestinal Physiology in Predicting the Reabsorption of Enterohepatic Circulation of Drugs

    • Kohei Nakamura
    • Atsushi Kambayashi
    • Satomi Onoue

    Original Research Article Open access 12 March 2024 Pages: 673 - 685

    

22. When will the Glomerular Filtration Rate in Former Preterm Neonates Catch up with Their Term Peers?

    • Yunjiao Wu
    • Karel Allegaert
    • Swantje Völler

    Original Research Article Open access 12 March 2024 Pages: 637 - 649

    

23. A Hollow Microneedle Equipped with a Micropillar for Improved Needle Insertion and Injection of Drug Solution

    • Mika Futaki
    • Kazuya Inamura
    • Hiroaki Todo

    Original Research Article 05 March 2024 Pages: 819 - 831

    

24. Intravitreal Delivery of PEGylated-ECO Plasmid DNA Nanoparticles for Gene Therapy of Stargardt Disease

    • Da Sun
    • Wenyu Sun
    • Zheng-Rong Lu

    Original Research Article 05 March 2024 Pages: 807 - 817

    

25. Clinical Investigation of Large Volume Subcutaneous Delivery up to 25 mL for Lean and Non-Lean Subjects

    • Xiangnan Dang
    • Han Shih
    • David S. Collins

    Original Research Article 05 March 2024 Pages: 751 - 763

    

26. Physiologically Based Pharmacokinetic Modeling to Unravel the Drug-gene Interactions of Venlafaxine: Based on Activity Score-dependent Metabolism by CYP2D6 and CYP2C19 Polymorphisms

    • Chaozhuang Shen
    • Hongyi Yang
    • Ling Wang

    Original Research Article 05 March 2024 Pages: 731 - 749

    

27. Healthcare Systems and Artificial Intelligence: Focus on Challenges and the International Regulatory Framework

    • Alessia Romagnoli
    • Francesco Ferrara
    • Andrea Zovi

    Perspectives 05 March 2024 Pages: 721 - 730

    

28. An Evaluation of Wet Granulation Process Selection for API Prone to Polymorphic Form Conversion in the Presence of Moisture and Heat

    • Freddy Arce
    • Yue Schuman
    • Divyakant Desai

    Original Research Article 21 February 2024 Pages: 595 - 607

    

29. Acetylcholine Analog-Modified Albumin Nanoparticles for the Enhanced and Synchronous Brain Delivery of Saponin Components of Panax Notoginseng

    • Ying Yu
    • Li Yun Wang
    • Cheng Xiao Wang

    Original Research Article 21 February 2024 Pages: 513 - 529

    

30. Research Landscape of Physiologically Based Pharmacokinetic Model Utilization in Different Fields: A Bibliometric Analysis (1999–2023)

    • Xin Wang
    • Jiangfan Wu
    • Shenyin Zhu

    Original Research Article 21 February 2024 Pages: 609 - 622

    

31. Antibody-Drug Conjugate Overview: a State-of-the-art Manufacturing Process and Control Strategy

    • Meng Li
    • Xueyu Zhao
    • Lan Wang

    Review Article 17 February 2024 Pages: 419 - 440

    

32. Co-delivery of Brinzolamide and Timolol from Micelles-laden Contact Lenses: In vitro and In Vivo Evaluation

    • Hongyu Yang
    • Faxing Zhang
    • Ji Li

    Original Research Article 16 February 2024 Pages: 531 - 546

    

33. Convolutional Neural Networks Guided Raman Spectroscopy as a Process Analytical Technology (PAT) Tool for Monitoring and Simultaneous Prediction of Monoclonal Antibody Charge Variants

    • Nitika Nitika
    • B. Keerthiveena
    • Anurag S. Rathore

    Original Research Article 16 February 2024 Pages: 463 - 479

    

34. Medicinal Polypharmacology in the Clinic – Translating the Polypharmacolome into Therapeutic Benefit

    • Muhammad Rafehi
    • Marius Möller
    • Sven Marcel Stefan

    Perspectives Open access 16 February 2024 Pages: 411 - 417

    

35. In Silico Study on the Contribution of the Follicular Route to Dermal Permeability of Small Molecules

    • Daniel Sebastia-Saez
    • Guoping Lian
    • Tao Chen

    Original Research Article Open access 13 February 2024 Pages: 567 - 576

    

36. Physiologically Based Pharmacokinetic (PBPK) Model Predictions of Disease Mediated Changes in Drug Disposition in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)

    • Jeffry Adiwidjaja
    • Jessica Spires
    • Kim L. R. Brouwer

    Original Research Article 13 February 2024 Pages: 441 - 462

    

37. Monte Carlo Optimization Method Based QSAR Modeling of Placental Barrier Permeability

    • Predrag Vukomanović
    • Milan Stefanović
    • Aleksandar M. Veselinović

    Original Research Article 09 February 2024 Pages: 493 - 500

    

38. Progress in the Application of Microneedles in Eye Disorders and the Proposal of the Upgraded Microneedle with Spinule

    • Qiannan Yang
    • Tingting Zhang
    • Xin Jin

    Review Article 09 February 2024 Pages: 203 - 222

    

39. Structure Based Machine Learning Prediction of Retention Times for LC Method Development of Pharmaceuticals

    • Jonathan Fine
    • Amanda K. Peterson Mann
    • Pankaj Aggarwal

    Original Research Article 08 February 2024 Pages: 365 - 374

    

40. Intradermal Vaccination with PLGA Nanoparticles via Dissolving Microneedles and Classical Injection Needles

    • Jihui Lee
    • Malene A. Neustrup
    • Koen van der Maaden

    Original Research Article Open access 08 February 2024 Pages: 305 - 319

    

41. Unraveling Pre-filled Syringe Needle Clogging: Exploring a Fresh Outlook Through Innovative Techniques

    • Guangli Hu
    • Daniel Bonanno
    • Vladimir Novak

    Original Research Article 07 February 2024 Pages: 547 - 556

    

42. Characterization of mRNA Lipid Nanoparticles by Electron Density Mapping Reconstruction: X-ray Scattering with Density from Solution Scattering (DENSS) Algorithm

    • Huy M. Dao
    • Khaled AboulFotouh
    • Robert O. Williams III

    Original Research Article 07 February 2024 Pages: 501 - 512

    

43. Green Tea Catechins Decrease Solubility of Raloxifene In Vitro and Its Systemic Exposure in Mice

    • Victoria O. Oyanna
    • Baron J. Bechtold
    • John D. Clarke

    Original Research Article 01 February 2024 Pages: 557 - 566

    

44. Novel Pharmaceutical Cocrystals of Tegafur: Synthesis, Performance, and Theoretical Studies

    • Haoran Mei
    • Na Wang
    • Hongxun Hao

    Original Research Article 30 January 2024 Pages: 577 - 593

    

45. The Effects of Excipients on Freeze-dried Monoclonal Antibody Formulation Degradation and Sub-Visible Particle Formation during Shaking

    • Meng-Jia Jin
    • Xin-Zhe Ge
    • Wei-Jie Fang

    Original Research Article 30 January 2024 Pages: 321 - 334

    

46. Coupling Drug Dissolution with BCS

    • Antony Simitopoulos
    • Athanasios Tsekouras
    • Panos Macheras

    Original Research Article Open access 30 January 2024 Pages: 481 - 491

    

47. WANTED DEAD OR ALIVE: New Thinking to Incentivize Drug Development

    • Michael S. Kinch

    Perspective 30 January 2024 Pages: 199 - 202

    

48. Keratinocyte Exosomes for Topical Delivery of Tofacitinib in Treatment of Psoriasis: an In Vitro/ In Vivo Study in Animal Model of Psoriasis

    • Pouya Dehghani
    • Jaleh Varshosaz
    • Mahdi Bodaghi

    Original Research Article Open access 23 January 2024 Pages: 263 - 279

    

49. Correction: Comparative Study of Dermal Pharmacokinetics Between Topical Drugs Using Open Flow Microperfusion in a Pig Model

    • Manfred Bodenlenz
    • Thean Yeoh
    • Thomas Birngruber

    Correction Open access 19 January 2024 Pages: 409 - 409

50. Time-Lapse Macro Imaging with Dissolution Tests for Exploring the Interrelationship Between Disintegration and Dissolution Behaviors of Solid Dosages

    • Yichen Yang
    • Jiajia Gengji
    • Li Deng

    Original Research Article 19 January 2024 Pages: 387 - 400