1. Pharmacokinetic Analysis of Drug Absorption from Muscle Based on a Physiological Diffusion Model: Effect of Molecular Size on Absorption

   • Eiji Nara
   • Masaaki Masegi
   • Mitsuru Hashida

   OriginalPaper Pages: 161 - 168

2. An Experimental Design Strategy for Quantitating Complex Pharmacokinetic Models: Enterohepatic Circulation with Time-Varying Gallbladder Emptying as an Example

   • Yow-Ming Chen Wang
   • Richard H. Reuning

   OriginalPaper Pages: 169 - 177

3. Potentiation of Cytotoxicity of Mitoxantrone Toward CHO-K1 Cells in Vitro by Dipyridamole

   • Pankaj B. Desai
   • Rajagopalan Sridhar

   OriginalPaper Pages: 178 - 181

4. A Novel Approach for the Determination of the Pain-Producing Potential of Intravenously Injected Substances in the Conscious Rat

   • John M. Marcek
   • William J. Seaman
   • Royal J. Weaver

   OriginalPaper Pages: 182 - 186

5. Cutaneous Metabolism of Nitroglycerin in Vitro. I. Homogenized Versus Intact Skin

   • Naruhito Higo
   • Robert S. Hinz
   • Richard H. Guy

   OriginalPaper Pages: 187 - 190

6. Enhanced Bioavailability of Cefoxitin Using Palmitoyl L-Carnitine. I. Enhancer Activity in Different Intestinal Regions

   • Steven C. Sutton
   • Edward L. LeCluyse
   • Joseph A. Fix

   OriginalPaper Pages: 191 - 194

7. Hydrophobic Anionic Gel Beads for Swelling-Controlled Drug Delivery

   • Cherng-Ju Kim
   • Ping I. Lee

   OriginalPaper Pages: 195 - 199

8. Biodegradable Pseudolatexes: The Chemical Stability of Poly(D,L-Lactide) and Poly (ε-Caprolactone) Nanoparticles in Aqueous Media

   • Mark D. Coffin
   • James W. McGinity

   OriginalPaper Pages: 200 - 205

9. Development of Extended-Release Solid Dispersions of Nonsteroidal Antiinflammatory Drugs with Aqueous Polymeric Dispersions: Optimization of Drug Release via a Curve-Fitting Technique

   • Chris Ho
   • George Chiaw-Chi Hwang

   OriginalPaper Pages: 206 - 210

10. Determination of Lidocaine Concentrations in Skin After Transdermal Iontophoresis: Effects of Vasoactive Drugs

    • J. Edmond Riviere
    • Nancy A. Monteiro-Riviere
    • Alfred O. Inman

    OriginalPaper Pages: 211 - 214

11. An Electrically Modulated Drug Delivery Device. II. Effect of Ionic Strength, Drug Concentration, and Temperature

    • Antony D'Emanuele
    • John N. Staniforth

    OriginalPaper Pages: 215 - 219

12. Factors Affecting the Release Rate of Terbutaline from Liposome Formulations After Intratracheal Instillation in the Guinea Pig

    • Robert M. Fielding
    • Robert M. Abra

    OriginalPaper Pages: 220 - 223

13. Pharmacokinetic Evaluation of Drug Interactions with Anti-Human Immunotrophic Virus (HIV) Drugs. III. 2′,3′-Dideoxycytidine (ddC) and Zidovudine in Monkeys

    • Mingxin Qian
    • Anne R. Swagler
    • James M. Gallo

    OriginalPaper Pages: 224 - 227

14. Competitive Inhibition of Zidovudine Clearance by Probenecid During Continuous Coadministration

    • Shekman L. Wong
    • Mohsen A. Hedaya
    • Ronald J. Sawchuk

    OriginalPaper Pages: 228 - 235

15. Effect of Chronic Hypertension on the Blood–Brain Barrier Permeability of Libenzapril

    • Jian-ping Tang
    • Ashok Rakhit
    • Srikumaran Melethil

    OriginalPaper Pages: 236 - 243

16. Bioavailability of Leuprolide Acetate Following Nasal and Inhalation Delivery to Rats and Healthy Humans

    • Akwete Adjei
    • Dean Sundberg
    • Alexander Chun

    OriginalPaper Pages: 244 - 249

17. Pharmaceutical Properties of Loracarbef: The Remarkable Solution Stability of an Oral 1-Carba-l-dethiacephalosporin Antibiotic

    • Carol E. Pasini
    • Joseph M. Indelicato

    OriginalPaper Pages: 250 - 254

18. Development and Evaluation of a Novel Dissolution Apparatus for Medicated Chewing Gum Products

    • James N. Rider
    • Ed L. Brunson
    • Alan B. Jones

    OriginalPaper Pages: 255 - 259

19. Prolonged Systemic Delivery of Peptide Drugs by Long-Circulating Liposomes: Illustration with Vasopressin in the Brattleboro Rat

    • Martin C. Woodle
    • Gert Storm
    • Francis C. Szoka, Jr

    OriginalPaper Pages: 260 - 265

20. The Influence of Sucrose, Dextran, and Hydroxypropyl-β-cyclodextrin as Lyoprotectants for a Freeze-Dried Mouse IgG_2a Monoclonal Antibody (MN12)

    • Maaike E. Ressing
    • Wim Jiskoot
    • Daan J. A. Crommelin

    OriginalPaper Pages: 266 - 270

21. Renal Tubular Handling of p-Aminohippurate and Epidermal Growth Factor (EGF) in Filtering and Nonfiltering Perfused Rat Kidneys

    • Dong-Chool Kim
    • Yuichi Sugiyama
    • Manabu Hanano

    OriginalPaper Pages: 271 - 275

22. Colonic Drug Delivery: Enhanced Release of Indomethacin from Cross-Linked Chondroitin Matrix in Rat Cecal Content

    • Abraham Rubinstein
    • David Nakar
    • Amnon Sintov

    Note Pages: 276 - 278

23. European Reviewers for Pharmaceutical Research (November 1990-November 1991)

    Legacy Pages: 279 - 280

24. Association News and Announcements

    Announcement Pages: 281 - 281