1. Semi-Automated Nanoprecipitation-System—An Option for Operator Independent, Scalable and Size Adjustable Nanoparticle Synthesis

   • René Rietscher
   • Carolin Thum
   • Marc Schneider

   Perspectives 30 December 2014 Pages: 1859 - 1863

   

2. Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach

   • Nikolaos Tsamandouras
   • Gemma Dickinson
   • Leon Aarons

   Research Paper 02 December 2014 Pages: 1864 - 1883

   

3. Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates

   • Siddharth Sukumaran
   • Kapil Gadkar
   • Kedan Lin

   Research Paper 02 December 2014 Pages: 1884 - 1893

   

4. A Novel Monocarboxylate Transporter Inhibitor as a Potential Treatment Strategy for γ-Hydroxybutyric Acid Overdose

   • Nisha Vijay
   • Bridget L. Morse
   • Marilyn E. Morris

   Research Paper 06 December 2014 Pages: 1894 - 1906

   

5. Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys

   • Dan Lu
   • Jin Yan Jin
   • Chee M. Ng

   Research Paper Open access 03 December 2014 Pages: 1907 - 1919

   

6. Cell Penetrating Peptides as Efficient Nanocarriers for Delivery of Antifungal Compound, Natamycin for the Treatment of Fungal Keratitis

   • Aastha Jain
   • Sushmita G. Shah
   • Archana Chugh

   Research Paper 03 December 2014 Pages: 1920 - 1930

   

7. Pharmacokinetic/Pharmacodynamic Modeling of Renin-Angiotensin Aldosterone Biomarkers Following Angiotensin-Converting Enzyme (ACE) Inhibition Therapy with Benazepril in Dogs

   • Jonathan P. Mochel
   • Martin Fink
   • Meindert Danhof

   Research Paper 02 December 2014 Pages: 1931 - 1946

   

8. Polypeptide-based Micelles for Delivery of Irinotecan: Physicochemical and In vivo Characterization

   • Thiruganesh Ramasamy
   • Ju Yeon Choi
   • Jong Oh Kim

   Research Paper 04 December 2014 Pages: 1947 - 1956

   

9. New Techniques to Assess In Vitro Release of siRNA from Nanoscale Polyplexes

   • Bettina Krieg
   • Markus Hirsch
   • Mark Helm

   Research Paper 09 December 2014 Pages: 1957 - 1974

   

10. MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics

    • Y. Yang
    • S. Nadanaciva
    • S. Q. Siler

    Research Paper Open access 12 December 2014 Pages: 1975 - 1992

    

11. Raman Mapping of Mannitol/Lysozyme Particles Produced Via Spray Drying and Single Droplet Drying

    • Jari Pekka Pajander
    • Sanni Matero
    • Mingshi Yang

    Research Paper 13 December 2014 Pages: 1993 - 2002

    

12. Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

    • Tianzhi Yang
    • Paige Martin
    • Shuhua Bai

    Research Paper 22 January 2015 Pages: 2003 - 2014

    

13. Modeling and Simulation Support Eltrombopag Dosing in Thrombocytopenic Patients with Chronic HCV Infection

    • Jianping Zhang
    • Mita Thapar
    • Mary B. Wire

    Research Paper 23 December 2014 Pages: 2015 - 2028

    

14. Physiology-Based Pharmacokinetics of Caspofungin for Adults and Paediatrics

    • Felix Stader
    • Gudrun Wuerthwein
    • Georg Hempel

    Research Paper 19 December 2014 Pages: 2029 - 2037

    

15. Exploring Advantages/Disadvantages and Improvements in Overcoming Gene Delivery Barriers of Amino Acid Modified Trimethylated Chitosan

    • Hao Zheng
    • Cui Tang
    • Chunhua Yin

    Research Paper 23 December 2014 Pages: 2038 - 2050

    

16. Dependence of PEI and PAMAM Gene Delivery on Clathrin- and Caveolin-Dependent Trafficking Pathways

    • Mark E. Hwang
    • Rahul K. Keswani
    • Daniel W. Pack

    Research Paper 17 December 2014 Pages: 2051 - 2059

    

17. Genomic Knockout of Endogenous Canine P-Glycoprotein in Wild-Type, Human P-Glycoprotein and Human BCRP Transfected MDCKII Cell Lines by Zinc Finger Nucleases

    • Dominik Gartzke
    • Jürgen Delzer
    • Gert Fricker

    Research Paper 19 December 2014 Pages: 2060 - 2071

    

18. Purification and Identification of High Molecular Weight Products Formed During Storage of Neutral Formulation of Human Insulin

    • Christian Fogt Hjorth
    • František Hubálek
    • Helle Naver

    Research Paper 14 January 2015 Pages: 2072 - 2085

    

19. Multi-Scale Modelling of Powder Dispersion in a Carrier-Based Inhalation System

    • Zhenbo Tong
    • Hidehiro Kamiya
    • Runyu Yang

    Research Paper 17 December 2014 Pages: 2086 - 2096

    

20. Cluster of Differentiation 44 Targeted Hyaluronic Acid Based Nanoparticles for MDR1 siRNA Delivery to Overcome Drug Resistance in Ovarian Cancer

    • Xiaoqian Yang
    • Arun K. Iyer
    • Zhenfeng Duan

    Research Paper 17 December 2014 Pages: 2097 - 2109

    

21. Controlled Electrostatic Self-Assembly of Ibuprofen-Cationic Dextran Nanoconjugates Prepared by low Energy Green Process – a Novel Delivery Tool for Poorly Soluble Drugs

    • Amos Olusegun Abioye
    • Adeola Kola-Mustapha

    Research Paper 20 December 2014 Pages: 2110 - 2131

    

22. Graphene Oxide - Gelatin Nanohybrids as Functional Tools for Enhanced Carboplatin Activity in Neuroblastoma Cells

    • Sami Makharza
    • Orazio Vittorio
    • Silke Hampel

    Research Paper 24 December 2014 Pages: 2132 - 2143

    

23. Immunomodulatory Effects of a Low-Dose Clarithromycin-Based Macrolide Solution Pressurised Metered Dose Inhaler

    • Mehra Haghi
    • Alessandro Saadat
    • Daniela Traini

    Research Paper 24 December 2014 Pages: 2144 - 2153

    

24. Ionic Liquid Versus Prodrug Strategy to Address Formulation Challenges

    • Anja Balk
    • Toni Widmer
    • Lorenz Meinel

    Research Paper 23 December 2014 Pages: 2154 - 2167

    

25. Erratum to: Fluorescent Dye Labeled Iron Oxide/Silica Core/Shell Nanoparticle as a Multimodal Imaging Probe

    • Eue Soon Jang
    • Seung Yong Lee
    • Cheol-Hee Ahn

    Erratum 02 December 2014 Pages: 2168 - 2168

26. AAPS Connection

    News 17 April 2015 Pages: 2169 - 2171