1. Particle Size Analysis in Pharmaceutics: Principles, Methods and Applications

   • Boris Y. Shekunov
   • Pratibhash Chattopadhyay
   • Albert H. L. Chow

   Review Article 27 December 2006 Pages: 203 - 227

   

2. Gene Therapy of the Other Genome: The Challenges of Treating Mitochondrial DNA Defects

   • Gerard G. M. D’Souza
   • Sarathi V. Boddapati
   • Volkmar Weissig

   Research Paper 19 December 2006 Pages: 228 - 238

   

3. Influence of Drug Transporter Polymorphisms on Pravastatin Pharmacokinetics in Humans

   • Kari T. Kivistö
   • Mikko Niemi

   Expert Review 20 December 2006 Pages: 239 - 247

   

4. Analytical Tools and Approaches for Metabolite Identification in Early Drug Discovery

   • Yuan Chen
   • Mario Monshouwer
   • William L. Fitch

   Expert Review 18 October 2006 Pages: 248 - 257

   

5. Spatio–temporal VEGF and PDGF Delivery Patterns Blood Vessel Formation and Maturation

   • Ruth R. Chen
   • Eduardo A. Silva
   • David J. Mooney

   Research Paper 27 December 2006 Pages: 258 - 264

   

6. Kinetic Considerations for the Quantitative Assessment of Efflux Activity and Inhibition: Implications for Understanding and Predicting the Effects of Efflux Inhibition

   • J. Cory Kalvass
   • Gary M. Pollack

   Research Paper 27 December 2006 Pages: 265 - 276

   

7. Iloprost-Containing Liposomes for Aerosol Application in Pulmonary Arterial Hypertension: Formulation Aspects and Stability

   • Elke Kleemann
   • Thomas Schmehl
   • Werner Seeger

   Research Paper 27 December 2006 Pages: 277 - 287

   

8. Mechanistic Investigation of Drug Release from Asymmetric Membrane Tablets: Effect of Media Gradients (Osmotic Pressure and Concentration), and Potential Coating Failures on In Vitro Release

   • Mary Tanya am Ende
   • Lee A. Miller

   Research Paper 19 December 2006 Pages: 288 - 297

   

9. PKPD Model of Interleukin-21 Effects on Thermoregulation in Monkeys—Application and Evaluation of Stochastic Differential Equations

   • Rune Viig Overgaard
   • Nick Holford
   • Henrik Madsen

   Research Paper 29 September 2006 Pages: 298 - 309

   

10. In SCID Mice with Transplanted Joint Tissues from Rheumatism Patients, a Model Mice of Human Rheumatoid Arthritis, Anti-human Fas Antibody (R-125224) Distributes Specifically to Human Synovium

    • Motoko Saito
    • Yasushi Yoshigae
    • Toshihiko Ikeda

    Research Paper 19 December 2006 Pages: 310 - 317

    

11. Assessment of the First and Second Generation Antihistamines Brain Penetration and Role of P-Glycoprotein

    • Tanja Obradovic
    • Glenn G. Dobson
    • Ismael J. Hidalgo

    Research Paper 19 December 2006 Pages: 318 - 327

    

12. Selective Androgen Receptor Modulator (SARM) Treatment Prevents Bone Loss and Reduces Body Fat in Ovariectomized Rats

    • Jeffrey D. Kearbey
    • Wenqing Gao
    • James T. Dalton

    Research Paper 25 October 2006 Pages: 328 - 335

    

13. The Effect of Film Thickness on Thermal Aerosol Generation

    • Dan J. Myers
    • Ryan D. Timmons
    • Josh D. Rabinowitz

    Research Paper 19 December 2006 Pages: 336 - 342

    

14. Preparation and Characterization of Nickel Nanoparticles for Binding to His-tag Proteins and Antigens

    • Jigna D. Patel
    • Ronan O’Carra
    • Russell J. Mumper

    Research Paper 19 December 2006 Pages: 343 - 352

    

15. PEPT1 Enhances the Uptake of Gabapentin via Trans-Stimulation of b^0,+ Exchange

    • Theresa V. Nguyen
    • David E. Smith
    • David Fleisher

    Research Paper 28 December 2006 Pages: 353 - 360

    

16. Influence of Realistic Inspiratory Flow Profiles on Fine Particle Fractions of Dry Powder Aerosol Formulations

    • Gary P. Martin
    • Christopher Marriott
    • Xian-Ming Zeng

    Research Paper 20 December 2006 Pages: 361 - 369

    

17. Influence of Processing Conditions on the Physical State of Mannitol—Implications in Freeze-Drying

    • Xiangmin Liao
    • Rajesh Krishnamurthy
    • Raj Suryanarayanan

    Research Paper 20 December 2006 Pages: 370 - 376

    

18. Interaction of Omeprazole with a Methylated Derivative of β-Cyclodextrin: Phase Solubility, NMR Spectroscopy and Molecular Simulation

    • Ana Figueiras
    • J. M. G. Sarraguça
    • Francisco J. B. Veiga

    Research Paper 20 December 2006 Pages: 377 - 389

    

19. LXR Alpha Transactivates Mouse Organic Solute Transporter Alpha and Beta via IR-1 Elements Shared with FXR

    • Masae Okuwaki
    • Tappei Takada
    • Hiroshi Suzuki

    Research Paper 20 December 2006 Pages: 390 - 398

    

20. Skin Irritation in Transdermal Drug Delivery Systems: A Strategy for its Reduction

    • Koji Kawahara
    • Kakuji Tojo

    Research Paper 27 December 2006 Pages: 399 - 408

    

21. AAPS Update

    Announcement 28 December 2006 Pages: 409 - 410