1. Plasmid Engineering for Controlled and Sustained Gene Expression for Nonviral Gene Therapy

   • Ethlinn V. B. van Gaal
   • Wim E. Hennink
   • Enrico Mastrobattista

   Expert Review 26 May 2006 Pages: 1053 - 1074

   

2. Metabonomics Techniques and Applications to Pharmaceutical Research & Development

   • John C. Lindon
   • Elaine Holmes
   • Jeremy K. Nicholson

   Expert Review 25 May 2006 Pages: 1075 - 1088

   

3. CYP Induction-Mediated Drug Interactions: in Vitro Assessment and Clinical Implications

   • Jiunn H. Lin

   Expert Review 26 May 2006 Pages: 1089 - 1116

   

4. Testosterone Hormone Replacement Therapy: State-of-the-Art and Emerging Technologies

   • Marie-Laure Leichtnam
   • Hervé Rolland
   • Richard H. Guy

   Expert Review 09 June 2006 Pages: 1117 - 1132

   

5. Effects of Antipsychotic Drugs on I_to, I_Na, I_sus, I_K1, and hERG: QT Prolongation, Structure Activity Relationship, and Network Analysis

   • William J. Crumb Jr.
   • Sean Ekins
   • Charles M. Beasley Jr.

   Feature Article 25 May 2006 Pages: 1133 - 1143

   

6. Oral Absorption of Poorly Water-Soluble Drugs: Computer Simulation of Fraction Absorbed in Humans from a Miniscale Dissolution Test

   • Ryusuke Takano
   • Kiyohiko Sugano
   • Shinji Yamashita

   Research Paper 25 May 2006 Pages: 1144 - 1156

   

7. Adaptive Neuro-Fuzzy Modeling of Poorly Soluble Drug Formulations

   • Dionysios Douroumis
   • Leontios J. Hadjileontiadis
   • Alfred Fahr

   Research Paper 25 May 2006 Pages: 1157 - 1164

   

8. Saturable Absorptive Transport of the Hydrophilic Organic Cation Ranitidine in Caco-2 Cells: Role of pH-Dependent Organic Cation Uptake System and P-Glycoprotein

   • David L. Bourdet
   • Dhiren R. Thakker

   Research Paper 08 June 2006 Pages: 1165 - 1177

   

9. Intestinal Absorptive Transport of the Hydrophilic Cation Ranitidine: A Kinetic Modeling Approach to Elucidate the Role of Uptake and Efflux Transporters and Paracellular vs. Transcellular Transport in Caco-2 Cells

   • David L. Bourdet
   • Gary M. Pollack
   • Dhiren R. Thakker

   Research Paper 08 June 2006 Pages: 1178 - 1187

   

10. Hepatic CYP3A Expression is Attenuated in Obese Mice Fed a High-Fat Diet

    • Kouichi Yoshinari
    • Shunsuke Takagi
    • Masao Miwa

    Research Paper 25 May 2006 Pages: 1188 - 1200

    

11. Characteristics of Substance P Transport Across the Blood–Brain Barrier

    • Arvind K. Chappa
    • Kenneth L. Audus
    • Susan M. Lunte

    Research Paper 01 June 2006 Pages: 1201 - 1208

    

12. Interaction of Ibuprofen and Other Structurally Related NSAIDs with the Sodium-Coupled Monocarboxylate Transporter SMCT1 (SLC5A8)

    • Shirou Itagaki
    • Elangovan Gopal
    • Vadivel Ganapathy

    Research Paper 01 June 2006 Pages: 1209 - 1216

    

13. Nasal Immunization with Anthrax Protective Antigen Protein Adjuvanted with Polyriboinosinic–Polyribocytidylic Acid Induced Strong Mucosal and Systemic Immunities

    • Brian R. Sloat
    • Zhengrong Cui

    Research Paper 25 May 2006 Pages: 1217 - 1226

    

14. Glucose Partition Coefficient and Diffusivity in the Lower Skin Layers

    • Enam Khalil
    • Kosmas Kretsos
    • Gerald B. Kasting

    Research Paper 26 May 2006 Pages: 1227 - 1234

    

15. ATP-Binding Cassette Transporter G2 Mediates the Efflux of Phototoxins on the Luminal Membrane of Retinal Capillary Endothelial Cells

    • Tomoko Asashima
    • Satoko Hori
    • Tetsuya Terasaki

    Research Paper 25 May 2006 Pages: 1235 - 1242

    

16. Enhanced Oral Paclitaxel Bioavailability After Administration of Paclitaxel-Loaded Lipid Nanocapsules

    • Sandra Peltier
    • Jean-Michel Oger
    • Jean-Pierre Benoît

    Research Paper 25 May 2006 Pages: 1243 - 1250

    

17. A Specific Picomolar Hybridization-Based ELISA Assay for the Determination of Phosphorothioate Oligonucleotides in Plasma and Cellular Matrices

    • Xiaohui Wei
    • Guowei Dai
    • Kenneth K. Chan

    Research Paper 25 May 2006 Pages: 1251 - 1264

    

18. Nontoxic Suramin as a Chemosensitizer in Patients: Dosing Nomogram Development

    • Danny Chen
    • Sae Heum Song
    • Jessie L-S. Au

    Research Paper 25 May 2006 Pages: 1265 - 1274

    

19. Rationale for Fixed Dosing of Pertuzumab in Cancer Patients Based on Population Pharmacokinetic Analysis

    • Chee M. Ng
    • Bert L. Lum
    • David Allison

    Research Paper 26 May 2006 Pages: 1275 - 1284

    

20. Gd-DTPA l-Cystine Bisamide Copolymers as Novel Biodegradable Macromolecular Contrast Agents for MR Blood Pool Imaging

    • Todd L. Kaneshiro
    • Tianyi Ke
    • Zheng-Rong Lu

    Research Paper 01 June 2006 Pages: 1285 - 1294

    

21. The Influence of Surfactant on PLGA Microsphere Glass Transition and Water Sorption: Remodeling the Surface Morphology to Attenuate the Burst Release

    • C. Bouissou
    • J. J. Rouse
    • C. F. van der Walle

    Research Paper 25 May 2006 Pages: 1295 - 1305

    

22. Hydrolytic Degradation and Drug Release of Ricinoleic Acid–Lactic Acid Copolyesters

    • Raia Slivniak
    • Aviva Ezra
    • Abraham J. Domb

    Research Paper 08 June 2006 Pages: 1306 - 1312

    

23. Complement Activation by Core–Shell Poly(isobutylcyanoacrylate)–Polysaccharide Nanoparticles: Influences of Surface Morphology, Length, and Type of Polysaccharide

    • Isabelle Bertholon
    • Christine Vauthier
    • Denis Labarre

    Research Paper 25 May 2006 Pages: 1313 - 1323

    

24. Expression of Basic Fibroblast Growth Factor Correlates with Resistance to Paclitaxel in Human Patient Tumors

    • Yuebo Gan
    • M. Guillaume Wientjes
    • Jessie L.-S. Au

    Research Paper 08 June 2006 Pages: 1324 - 1331

    

25. Reverse Hexagonal Phase Nanodispersion of Monoolein and Oleic Acid for Topical Delivery of Peptides: in Vitro and in Vivo Skin Penetration of Cyclosporin A

    • Luciana B. Lopes
    • Denise A. Ferreira
    • M. Vitória L. B. Bentley

    Research Paper 25 May 2006 Pages: 1332 - 1342

    

26. Electron Beam and Gamma Radiolysis of Solid-State Metoclopramide

    • Aubert Maquille
    • Catherine Slegers
    • Bernard Tilquin

    Research Paper 08 June 2006 Pages: 1343 - 1349

    

27. FTIR and nDSC as Analytical Tools for High-Concentration Protein Formulations

    • Susanne Matheus
    • Wolfgang Friess
    • Hanns-Christian Mahler

    Research Paper 26 May 2006 Pages: 1350 - 1363

    

28. Effect of Oropharyngeal Length in Drug Lung Delivery via Suspension Pressurized Metered Dose Inhalers

    • T. Ehtezazi
    • D. R. Allanson
    • C. O'Callaghan

    Research Paper 26 May 2006 Pages: 1364 - 1372

    

29. Canine Intestinal Contents vs. Simulated Media for the Assessment of Solubility of Two Weak Bases in the Human Small Intestinal Contents

    • Lida Kalantzi
    • Eva Persson
    • Christos Reppas

    Research Paper 25 May 2006 Pages: 1373 - 1381

    

30. Protein Structural Conformation and Not Second Virial Coefficient Relates to Long-Term Irreversible Aggregation of a Monoclonal Antibody and Ovalbumin in Solution

    • Harminder Bajaj
    • Vikas K. Sharma
    • Devendra S. Kalonia

    Research Paper 25 May 2006 Pages: 1382 - 1394

    

31. Design and Evaluation of Celecoxib Porous Particles using Melt Sonocrystallization

    • Anant Paradkar
    • Manish Maheshwari
    • Peter York

    Research Paper 07 June 2006 Pages: 1395 - 1400

    

32. AAPS Update

    OriginalPaper 27 June 2006 Pages: 1401 - 1402