Optimizing Drug Development: Strategies to Assess Drug Metabolism/Transporter Interaction Potential—Toward a Consensus Geoffrey T. TuckerJ. Brian HoustonShiew-Mei Huang Conference Report Pages: 1071 - 1080
The Measurement of Small Quantities of Amorphous Material—Should We Be Considering the Rigid Amorphous Fraction? Duncan Q. M. CraigVicky L. KettDuncan M. Price OriginalPaper Pages: 1081 - 1082
Sequential Processing of Human ProIL-1β by Caspase-1 and Subsequent Folding Determined by a Combined In Vitro and In Silico Approach Peter W. SwaanDaren L. KnoellMark D. Wewers OriginalPaper Pages: 1083 - 1090
Receptor-Mediated Gene Targeting to Tissues In Vivo Following Intravenous Administration of Pegylated Immunoliposomes Ningya ShiRuben J. BoadoWilliam M. Pardridge OriginalPaper Pages: 1091 - 1095
Inhibition of HIV-1 in Cell Culture by Oligonucleotide-Loaded Nanoparticles Myriam BertonPriscilla TurelliRobert Gurny OriginalPaper Pages: 1096 - 1101
Characterizing the Expression of CYP3A4 and Efflux Transporters (P-gp, MRP1, and MRP2) in CYP3A4-Transfected Caco-2 Cells After Induction with Sodium Butyrate and the Phorbol Ester 12-O-Tetradecanoylphorbol-13-Acetate Carolyn L. CumminsLara M. MangraviteLeslie Z. Benet OriginalPaper Pages: 1102 - 1109
Transport of Peptidomimetic Thrombin Inhibitors with a 3-Amidino-Phenylalanine Structure: Permeability and Efflux Mechanism in Monolayers of a Human Intestinal Cell Line (Caco-2) Walter KammJörg HauptmannThomas Kissel OriginalPaper Pages: 1110 - 1118
Sinusoidal Efflux of Taurocholate Is Enhanced in Mrp2-Deficient Rat Liver Hidetaka AkitaHiroshi SuzukiYuichi Sugiyama OriginalPaper Pages: 1119 - 1125
Mucosal Uptake of Gabapentin (Neurontin) vs. Pregabalin in the Small Intestine Nusara PiyapolrungrojCheng LiDavid Fleisher OriginalPaper Pages: 1126 - 1130
Intestinal First-Pass Metabolism of Eperisone in the Rat Kiyoshi MiharaMina MatsumuraHiroyasu Ogata OriginalPaper Pages: 1131 - 1137
Transport of Lipophilic Drug Molecules in a New Mucus-Secreting Cell Culture Model Based on HT29-MTX Cells Isabel BehrensPatric StenbergThomas Kissel OriginalPaper Pages: 1138 - 1145
The Effect of Polyethylene Glycol 400 on Gastrointestinal Transit: Implications for the Formulation of Poorly-Water Soluble Drugs Abdul W. BasitJ. Michael NewtonLarry F. Lacey OriginalPaper Pages: 1146 - 1150
Transdermal Delivery of Heparin and Low-Molecular Weight Heparin Using Low-Frequency Ultrasound Samir MitragotriJoseph Kost OriginalPaper Pages: 1151 - 1156
Long-Circulating PEGylated Polycyanoacrylate Nanoparticles as New Drug Carrier for Brain Delivery Pilar CalvoBruno GouritinPatrick Couvreur OriginalPaper Pages: 1157 - 1166
Inhibitory Effects of Novel Hydrophilic Cyclodextrin Derivatives on Nitric Oxide Production in Macrophages Stimulated with Lipopolysaccharide Hidetoshi ArimaYoji NishimotoKaneto Uekama OriginalPaper Pages: 1167 - 1173
A Pharmacokinetic Model to Predict the PK Interaction of L-Dopa and Benserazide in Rats Susan GrangeNicholas H. G. HolfordTheodor W. Guentert OriginalPaper Pages: 1174 - 1184
Effects of Food on the Pharmacokinetics of Methylphenidate K. K. MidhaG. McKayJ. W. Hubbard OriginalPaper Pages: 1185 - 1189
A Physiologically Based Pharmacokinetic Analysis of Capecitabine, a Triple Prodrug of 5-FU, in Humans: The Mechanism for Tumor-Selective Accumulation of 5-FU Yuko TsukamotoYukio KatoYuichi Sugiyama OriginalPaper Pages: 1190 - 1202
Kinetic Analysis of the Disposition of Insulin-Like Growth Factor 1 in Healthy Volunteers Naomi MizunoYukio KatoYuichi Sugiyama OriginalPaper Pages: 1203 - 1209
Modeling and Simulation for Clinical Trial Design Involving a Categorical Response: A Phase II Case Study with Naratriptan Ivan NestorovGordon GrahamPeter Coates OriginalPaper Pages: 1210 - 1219
Power Spectral Analysis of Heart Rate Variability in Rats as a Quantitative Tool in the PK-PD Analysis of the Parasympatholytic Activity of Atropine Itay PerlsteinDavid StepenskyAmnon Hoffman OriginalPaper Pages: 1220 - 1225
Osmotic Properties of Sulfobutylether and Hydroxypropyl Cyclodextrins Erika A. ZannouWilliam H. StrengValentino J. Stella OriginalPaper Pages: 1226 - 1231
Enzymatic Activities in the Microsomes Prepared from Rat Small Intestinal Epithelial Cells by Differential Procedures Kiminori MohriYoshihiro Uesawa BriefCommunication Pages: 1232 - 1236
