1. EDITORIAL

   Editorial Board Pages: 1245 - 1246

2. The Many Faces of Pharmaceutical Research

   • Bernard Testa

   Editorial Commentary Pages: 1247 - 1247

3. Methodologies for Pharmaceutical Effectiveness and Pharmacoeconomics Research

   • Carol B. Gable

   Commentary Pages: 1248 - 1249

4. Optimization of Lyophilization Conditions for Recombinant Human Interleukin-2 by Dried-State Conformational Analysis Using Fourier-Transform Infrared Spectroscopy

   • Steven J. Prestrelski
   • Katherine A. Pikal
   • Tsutomu Arakawa

   OriginalPaper Pages: 1250 - 1259

5. Vial Lyophilization: Calculations on Rate Limitation During Primary Drying

   • Hester Ybema
   • Lia Kolkman-Roodbeen
   • Herman Vromans

   OriginalPaper Pages: 1260 - 1263

6. Computer Simulation of Tablet Motion in Coating Drum

   • Kenji Yamane
   • Toshiharu Sato
   • Yutaka Tsuji

   OriginalPaper Pages: 1264 - 1268

7. Preparation of Controlled-Release Coevaporates of Dipyridamole by Loading Neutral Pellets in a Fluidized-Bed Coating System

   • Deniz B. Beten
   • Karim Amighi
   • André J. Moës

   OriginalPaper Pages: 1269 - 1272

8. Physicochemical Characterization of Parenteral Lipid Emulsion: Influence of Cosurfactants on Flocculation and Coalescence

   • Tetsuo Yamaguchi
   • Kaori Nishizaki
   • Hiroyuki Ohshima

   OriginalPaper Pages: 1273 - 1278

9. Hydrophobic Contribution Constants of Amino Acid Residues to the Hydrophobicities of Oligopeptides

   • Hua Gao
   • Fengzhen Wang
   • Eric J. Lien

   OriginalPaper Pages: 1279 - 1283

10. Precipitation of Insulinotropin in the Presence of Protamine: Effect of Phenol and Zinc on the Isophane Ratio and the Insulinotropin Concentration in the Supernatant

    • Yesook Kim
    • Carol A. Rose

    OriginalPaper Pages: 1284 - 1288

11. Cholate-Induced Disruption of Calcitonin-Loaded Liposomes: Formation of Trypsin-Resistant Lipid-Calcitonin-Cholate Complexes

    • Albertina Ariën
    • Nelly Toulmé-Henry
    • Bernard Dupuy

    OriginalPaper Pages: 1289 - 1292

12. Mucoadhesive Polymers in Peroral Peptide Drug Delivery. II. Carbomer and Polycarbophil Are Potent Inhibitors of the Intestinal Proteolytic Enzyme Trypsin

    • Henrik L. Lueßen
    • J. Coos Verhoef
    • Hans E. Junginger

    OriginalPaper Pages: 1293 - 1298

13. The Intestinal Transport Mechanism of Fluoroquinolones: Inhibitory Effect of Ciprofloxacin, an Enoxacin Derivative, on the Membrane Potential-Dependent Uptake of Enoxacin

    • Takeshi Hirano
    • Ken Iseki
    • Katsumi Miyazaki

    OriginalPaper Pages: 1299 - 1303

14. Possible Involvement of Multiple P-Glycoprotein-Mediated Efflux Systems in the Transport of Verapamil and Other Organic Cations Across Rat Intestine

    • Hiroshi Saitoh
    • Bruce J. Aungst

    OriginalPaper Pages: 1304 - 1310

15. Regional Gastrointestinal Absorption of Ranitidine in the Rat

    • Benjamin Suttle
    • Kim L. R. Brouwer

    OriginalPaper Pages: 1311 - 1315

16. Gastrointestinal Transit and Distribution of Ranitidine in the Rat

    • A. Benjamin Suttle
    • Kim L. R. Brouwer

    OriginalPaper Pages: 1316 - 1322

17. First-Pass Accumulation of Salicylic Acid in Gut Tissue After Absorption in Anesthetized Rat

    • Young M. Choi
    • Sang M. Chung
    • Win L. Chiou

    OriginalPaper Pages: 1323 - 1327

18. Drug Delivery Studies in Caco-2 Monolayers. IV. Absorption Enhancer Effects of Cyclodextrins

    • Lars Hovgaard
    • Helle Brøndsted

    OriginalPaper Pages: 1328 - 1332

19. New Evaluation Method for in Vitro/in Vivo Correlation of Enteric-Coated Multiple Unit Dosage Forms

    • Takashi Hayashi
    • Toshihiro Ogura
    • Yasushi Takagishi

    OriginalPaper Pages: 1333 - 1337

20. Development and in Vitro-in Vivo Evaluation of a Multiparticulate Sustained Release Formulation of Diltiazem

    • Shun Por Li
    • Robert G. Felt
    • Robert O. Williams III

    OriginalPaper Pages: 1338 - 1342

21. The Pulmonary Absorption of Aerosolized and Intratracheally Instilled rhG-CSF and monoPEGylated rhG-CSF

    • Ralph W. Niven
    • K. Lane Whitcomb
    • Olaf B. Kinstler

    OriginalPaper Pages: 1343 - 1349

22. Pharmacokinetics of 1 -(2-Deoxy-2-fluoro-β-L-arabino-furanosyl)-5-methyluracil (L-FMAU) in Rats

    • Jennifer D. Wright
    • Tianwei Ma
    • F. Douglas Boudinot

    OriginalPaper Pages: 1350 - 1353

23. Absorption of Sunscreens and Other Compounds Through Human Skin in Vivo: Derivation of a Method to Predict Maximum Fluxes

    • Ursula Hagedorn-Leweke
    • Bernhard C. Lippold

    OriginalPaper Pages: 1354 - 1360

24. Hydrolysis of the Prodrug, 2′, 3′, 5′ -Triacetyl-6-azauridine

    • C. M. Riley
    • M. A. Mummert
    • M. Slavik

    OriginalPaper Pages: 1361 - 1370

25. Hydroxypropyl-β-Cyclodextrin Increases the Aqueous Solubility and Stability of Pilocarpine Prodrugs

    • Pekka Jarho
    • Arto Urtti
    • Tomi Järvinen

    OriginalPaper Pages: 1371 - 1375

26. Measurement of the Diffusion of 2,2,2-trifluoroacetamide Within Thermoresponsive Hydrogels Using NMR Imaging

    • R. Dinarvand
    • B. Wood
    • A. D'Emanuele

    Note Pages: 1376 - 1379

27. Particle Size Distribution of Single and Multiple Sprays of Salbutamol Metered-Dose Inhalers (MDIs)

    • Susan J. Graham
    • Robert C. Lawrence
    • Richard K. Pike

    Note Pages: 1380 - 1384

28. Influence of Surface Properties on the Inflammatory Response to Polymeric Nanoparticles

    • Rocío Fernández-Urrusuno
    • Elias Fattal
    • Patrick Couvreur

    Note Pages: 1385 - 1387

29. Evidence for the Lack of a Human Metabolic Isotope Effect of a Deuterium Analog of Fluphenazine

    • Salim Hadad
    • John W. Hubbard
    • Kamal K. Midha

    Note Pages: 1388 - 1390