1. Use of Stable Isotopes for Evaluation of Drug Delivery Systems: Comparison of Ibuprofen Release in Vivo and in Vitro from Two Biphasic Release Formulations Utilizing Different Rate-Controlling Polymers

   • Don L. Theis
   • Leo J. Lucisano
   • Gordon W. Halstead

   OriginalPaper Pages: 1069 - 1076

2. Chemical Stability of Ethyl Icosapentate Against Autoxidation. II. Effect of Photoirradiation on Oxidation Kinetics

   • Reiko Teraoka
   • Makoto Otsuka
   • Yoshihisa Matsuda

   OriginalPaper Pages: 1077 - 1081

3. Synthesis and in Vitro Study of a Diglyceride Prodrug of a Peptide

   • Florence Delie
   • Patrick Couvreur
   • Yves Letourneux

   OriginalPaper Pages: 1082 - 1087

4. Conformation of Amiodarone · HC1: A Solution and Solid State ¹³C-NMR Study

   • Renée C. Rao
   • Frédéric Lefebvre
   • Michel Gachon

   OriginalPaper Pages: 1088 - 1092

5. Evaluation of Solubilizers in the Drug Release Testing of Hydrophilic Matrix Extended-Release Tablets of Felodipine

   • Bertil Abrahamsson
   • Dick Johansson
   • Karin Wingstrand

   OriginalPaper Pages: 1093 - 1097

6. An Improved Microscope Stage for Direct Observation of Freezing and Freeze Drying

   • Steven L. Nail
   • Lih-Min Her
   • Lisa L. Nail

   OriginalPaper Pages: 1098 - 1100

7. Pulmonary Delivery of Powders and Solutions Containing Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) to the Rabbit

   • Ralph W. Niven
   • Fred D. Lott
   • Judith M. Cribbs

   OriginalPaper Pages: 1101 - 1109

8. Novel Delivery of Antioxidant Enzyme Catalase to Alveolar Macrophages by Fc Receptor-Mediated Endocytosis

   • Jeannine Harrison
   • Xianglin Shi
   • Yongyut Rojanasakul

   OriginalPaper Pages: 1110 - 1114

9. Stability of Acyl Derivatives of Insulin in the Small Intestine: Relative Importance of Insulin Association Characteristics in Aqueous Solution

   • Hiroyuki Asada
   • Takayuki Douen
   • Shozo Muranishi

   OriginalPaper Pages: 1115 - 1120

10. Receptor-Mediated Peptide Delivery in Pulmonary Epithelial Monolayers

    • Deepa Deshpande
    • David Toledo-Velasquez
    • Yongyut Rojanasakul

    OriginalPaper Pages: 1121 - 1126

11. Comparison of Cell Proliferation and Toxicity Assays Using Two Cationic Liposomes

    • Katriina Lappalainen
    • Ilpo Jääskeläinen
    • Stina Syrjänen

    OriginalPaper Pages: 1127 - 1131

12. Intestinal Permeability Enhancement: Efficacy, Acute Local Toxicity, and Reversibility

    • E. Scott Swenson
    • William B. Milisen
    • William Curatolo

    OriginalPaper Pages: 1132 - 1142

13. Preparation of Three-Month Depot Injectable Microspheres of Leuprorelin Acetate Using Biodegradable Polymers

    • Hiroaki Okada
    • Yayoi Doken
    • Hajime Toguchi

    OriginalPaper Pages: 1143 - 1147

14. Effect of Medium-Chain Glycerides on Physiological Properties of Rabbit Intestinal Epithelium in Vitro

    • Ping-Yang Yeh
    • Philip L. Smith
    • Harma Ellens

    OriginalPaper Pages: 1148 - 1154

15. Characterization of Esterase and Alcohol Dehydrogenase Activity in Skin. Metabolism of Retinyl Palmitate to Retinol (Vitamin A) During Percutaneous Absorption

    • James Boehnlein
    • Adel Sakr
    • Robert L. Bronaugh

    OriginalPaper Pages: 1155 - 1159

16. Uptake of Nanoparticles by Rat Glomerular Mesangial Cells in Vivo and in Vitro

    • Luc Manil
    • Jean-Claude Davin
    • Philippe Mahieu

    OriginalPaper Pages: 1160 - 1165

17. Non-Isothermal and Isothermal Crystallization of Sucrose from the Amorphous State

    • Azita Saleki-Gerhardt
    • George Zografi

    OriginalPaper Pages: 1166 - 1173

18. Cyclodextrins as Mucosal Absorption Promoters of Insulin. II. Effects of β-Cyclodextrin Derivatives on α-Chymotryptic Degradation and Enteral Absorption of Insulin in Rats

    • Zezhi Shao
    • Yuping Li
    • Ashim K. Mitra

    OriginalPaper Pages: 1174 - 1179

19. Enhanced Delivery and Antitumor Activity of Doxorubicin Using Long-Circulating Thermosensitive Liposomes Containing Amphipathic Polyethylene Glycol in Combination with Local Hyperthermia

    • Sakae Unezaki
    • Kazuo Maruyama
    • Motoharu Iwatsuru

    OriginalPaper Pages: 1180 - 1185

20. Chitosan as a Novel Nasal Delivery System for Peptide Drugs

    • Lisbeth Illum
    • Nidal F. Farraj
    • Stanley S. Davis

    OriginalPaper Pages: 1186 - 1189

21. A Modified Product Inhibition Model Describes the Nonlinear Pharmacokinetics of Nicorandil in Rats

    • Elizabeth L. Bachert
    • Zhuang-wu Li
    • Ho-Leung Fung

    OriginalPaper Pages: 1190 - 1198

22. Sustained Suppression of the Pituitary-Gonadal Axis by Leuprorelin Three-Month Depot Microspheres in Rats and Dogs

    • Hiroaki Okada
    • Yayoi Doken
    • Hajime Toguchi

    OriginalPaper Pages: 1199 - 1203

23. Phenobarbital Disposition in Adult and Neonatal Rabbits

    • Sun Dong Yoo
    • David E. Burgio
    • Patrick J. McNamara

    Note Pages: 1204 - 1206

24. Study of the Interaction Between β-Cyclodextrin and Chlorhexidine

    • Hong Qi
    • Toshiaki Nishihata
    • J. Howard Rytting

    Note Pages: 1207 - 1210

25. Synthesis of Novel Aminopropylguanidine Derivatives with Potential Antihypertensive Activity

    • Unsal Calis
    • John R. Finch
    • George A. Digenis

    Note Pages: 1211 - 1215

26. Workshop III Report: Scaleup of Liquid and Semisolid Disperse Systems

    • G. A. Van Buskirk
    • V. P. Shah
    • J. L. Zatz

    Legacy Pages: 1216 - 1220

27. Normal Volunteers Should Not Be Used for Bioavailability or Bioequivalence Studies of Clozapine

    • Rolf Pokorny
    • Marion J. Finkel
    • William T. Robinson

    Letter to the Editor Pages: 1221 - 1221

28. 2ND EUROPEAN CONGRESS OF PHARMACEUTICAL SCIENCES EIGHTH ANNUAL PHARMACOKINETICS COURSE FOR PHARMACEUTICAL SCIENTISTS ONE-WEEK WORKSHOP ON ADVANCED METHODS IN PHARMACOKINETICS

    Announcement Pages: 1222 - 1222

29. ERRATUM

    Erratum Pages: 1222 - 1222