1. Commentary

   ReviewPaper Pages: 283 - 283

2. The limits of template-directed synthesis with nucleoside-5′-phosphoro(2-methyl)imidazolides

   • Aubrey R. Hill Jr.
   • Leslie E. Orgel
   • Taifeng Wu

   OriginalPaper Pages: 285 - 290

3. Utilization of cofactors expands metabolism in a new RNA world

   • Gregory J. Connell
   • Eric L. Christian

   OriginalPaper Pages: 291 - 297

4. N6-substituted adenine derivatives and RNA primitive catalysts

   • Jean-Luc Décout
   • Marie-Christine Maurel

   OriginalPaper Pages: 299 - 306

5. Catalysis and prebiotic RNA synthesis

   • James P. Ferris

   OriginalPaper Pages: 307 - 315

6. Is ligation the only solution to the pyrophosphate problem?

   • J. Visscher
   • R. Jongbloets
   • Alan W. Schwartz

   OriginalPaper Pages: 317 - 321

7. Peptide nucleic acid (PNA): A model structure for the primordial genetic material?

   • Peter Egil Nielsen

   OriginalPaper Pages: 323 - 327

8. The RNA-world and co-evolution hypotheses and the origin of life: Implications, research strategies and perspectives

   • Noam Lahav

   OriginalPaper Pages: 329 - 344

9. The evolutionary change of the genetic code as restricted by the anticodon and identity of transfer RNA

   • Takuya Ueda
   • Kimitsuna Watanabe

   OriginalPaper Pages: 345 - 364

10. Experimental investigation of an RNA sequence space

    • Youn-Hyung Lee
    • Lisa Dsouza
    • George E. Fox

    OriginalPaper Pages: 365 - 372

11. RNA based evolutionary optimization

    • Peter Schuster

    OriginalPaper Pages: 373 - 391

12. On concerted origin of transfer RNAs with complementary anticodons

    • Sergei Rodin
    • Susumu Ohno
    • Andrei Rodin

    OriginalPaper Pages: 393 - 418

13. Applicability of PM3 to transphosphorylation reaction path: Toward designing a minimal ribozyme

    • John I. Manchester
    • Masayuki Shibata
    • Robert Rein

    OriginalPaper Pages: 419 - 427

14. Announcement: Exobiological strategy for the exploration of Mars

    Announcement Pages: 431 - 431