1. Dedication

   OriginalPaper Pages: 1 - 1

2. Preface

   • Rafael Alvarez-Gonzalez

   OriginalPaper Pages: 3 - 3

3. Poly ADP-ribosylation: A DNA break signal mechanism

   • Felix R. Althaus
   • Hanna E. Kleczowska
   • Bernhard Auer

   OriginalPaper Pages: 5 - 11

4. Measurement of poly(ADP-ribose) glycohydrolase activity by high resolution polyacrylamide gel electrophoresis: Specific inhibition by histones and nuclear matrix proteins

   • Gustavo Pacheco-Rodriguez
   • Rafael Alvarez-Gonzalez

   OriginalPaper Pages: 13 - 18

5. Regulatory mechanisms of poly(ADP-ribose) polymerase

   • Rafael Alvarez-Gonzalez
   • Trent A. Watkins
   • Hilda Mendoza-Alvarez

   OriginalPaper Pages: 19 - 22

6. Poly(ADP-ribose) polymerase: A guardian of the genome that facilitates DNA repair by protecting against DNA recombination

   • Satadal Chatterjee
   • Sosamma J. Berger
   • Nathan A. Berger

   OriginalPaper Pages: 23 - 30

7. Trans-dominant inhibition of poly(ADP-ribosyl)ation potentiates alkylation-induced shuttle-vector mutagenesis in Chinese hamster cells

   • Junko Tatsumi-Miyajima
   • Jan-Heiner Küpper
   • Alexander Bürkle

   OriginalPaper Pages: 31 - 35

8. Clostridial toxins: Molecular probes of Rho-dependent signaling and apoptosis

   • David A. Bobak

   OriginalPaper Pages: 37 - 42

9. Role of brefeldin A-dependent ADP-ribosylation in the control of intracellular membrane transport

   • Maria Guiseppina Silletta
   • Antonino Colanzi
   • Daniela Corda

   OriginalPaper Pages: 43 - 51

10. A dual approach in the study of poly (ADP-ribose) polymerase: In vitro random mutagenesis and generation of deficient mice

    • Carlotta Trucco
    • Véronique Rolli
    • Gilbert de Murcia

    OriginalPaper Pages: 53 - 60

11. The RT6 (Art2) family of ADP-ribosyltransferases in rat and mouse

    • Rita Bortell
    • Toshihiro Kanaitsuka
    • Dale L. Greiner

    OriginalPaper Pages: 61 - 68

12. Mapping the role of NAD metabolism inprevention and treatment of carcinogenesis

    • Elaine L. Jacobson
    • Elaine L. Jacobson
    • Arnold C. Huang

    OriginalPaper Pages: 69 - 74

13. Molecular heterogeneity and regulation of poly(ADP-ribose) glycohydrolase

    • Jean-Christophe Amé
    • Elaine L. Jacobson
    • Myron K. Jacobson

    OriginalPaper Pages: 75 - 81

14. Niacin deficiency increases the sensitivity of rats to the short and long term effects of ethylnitrosourea treatment

    • Ann C. Boyonoski
    • Lisa M. Gallacher
    • James B. Kirkland

    OriginalPaper Pages: 83 - 87

15. Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes

    • Hon Cheung Lee
    • Cyrus Munshi
    • Richard Graeff

    OriginalPaper Pages: 89 - 98

16. Identification of the archaeal NMN adenylyltransferase gene

    • Nadia Raffaelli
    • Monica Emanuelli
    • Giulio Magni

    OriginalPaper Pages: 99 - 102

17. Functional analysis of poly(ADP-ribose) polymerase in Drosophila melanogaster

    • Masanao Miwa
    • Shuji Hanai
    • Kazuhiko Uchida

    OriginalPaper Pages: 103 - 108

18. Characterization of NAD:arginine ADP-ribosyltransferases

    • Joel Moss
    • Enrico Balducci
    • Anna Zolkiewska

    OriginalPaper Pages: 109 - 113

19. The CD38-cyclic ADP-ribose signaling system in insulin secretion

    • Hiroshi Okamoto

    OriginalPaper Pages: 115 - 118

20. Newly discovered anti-inflammatory properties of the benzamides and nicotinamides

    • Ronald W. Pero
    • Bengt Axelsson
    • Graeme Dougherty

    OriginalPaper Pages: 119 - 125

21. Poly(ADP-ribose) turnover in quail myoblast cells: Relation between the polymer level and its catabolism by glycohydrolase

    • E.B. Affar
    • R.G. Shah
    • G.G. Poirier

    OriginalPaper Pages: 127 - 135

22. Involvement of PARP and poly(ADP-ribosyl)ation in the early stages of apoptosis and DNA replication

    • Cynthia Marie Simbulan-Rosenthal
    • Dean S. Rosenthal
    • Mark E. Smulson

    OriginalPaper Pages: 137 - 148

23. Function of poly(ADP-ribose) polymerase in response to DNA damage: Gene-disruption study in mice

    • Mitsuko Matsutani
    • Tadashige Nozaki
    • Takashi Sugimura

    OriginalPaper Pages: 149 - 152

24. Activation of toxin ADP-ribosyltransferases by eukaryotic ADP-ribosylation factors

    • Joel Moss
    • Martha Vaughan

    OriginalPaper Pages: 153 - 157

25. Volume Contents

    OriginalPaper Pages: 159 - 161