Volume 42, Issue 5 | Journal of Pharmacokinetics and Pharmacodynamics

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Volume 42, Issue 5

October 2015

Special Issue: Honoring Gerhard Levy and 50 Years of PK/PD

Issue Editors:

William J. Jusko,
Ho-Leung Fung

11 articles in this issue

Preface to the special issue to honor Gerhard Levy and 50 years of PK/PD
William J. Jusko
Ho-Leung Fung
Editorial 24 September 2015 Pages: 427 - 427
Perspectives on the history and scientific contributions of Gerhard Levy
Ho-Leung Fung
William J. Jusko
Original Paper 24 September 2015 Pages: 429 - 446
Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models
Meindert Danhof
Review Paper Open access 30 August 2015 Pages: 447 - 462
Prediction and validation of enzyme and transporter off-targets for metformin
Sook Wah Yee
Lawrence Lin
Kathleen M. Giacomini
Original Paper 03 September 2015 Pages: 463 - 475
Mechanism-based mathematical modeling of combined gemcitabine and birinapant in pancreatic cancer cells
Xu Zhu
Robert M. Straubinger
William J. Jusko
Original Paper 08 August 2015 Pages: 477 - 496
Semi-mechanistic kidney model incorporating physiologically-relevant fluid reabsorption and transporter-mediated renal reabsorption: pharmacokinetics of γ-hydroxybutyric acid and l-lactate in rats
Rutwij A. Dave
Marilyn E. Morris
Original Paper 04 September 2015 Pages: 497 - 513
Bayesian population modeling of drug dosing adherence
Kelly Fellows
Colin J. Stoneking
Murali Ramanathan
Original Paper 29 August 2015 Pages: 515 - 525
Scale-up of a physiologically-based pharmacokinetic model to predict the disposition of monoclonal antibodies in monkeys
Patrick M. Glassman
Yang Chen
Joseph P. Balthasar
Original Paper 12 September 2015 Pages: 527 - 540
Physiologically-based pharmacokinetic modeling of target-mediated drug disposition of bortezomib in mice
Li Zhang
Donald E. Mager
Original Paper 21 September 2015 Pages: 541 - 552
Pharmacokinetic and pharmacodynamic considerations for the next generation protein therapeutics
Dhaval K. Shah
Original Paper 15 September 2015 Pages: 553 - 571
Pharmacodynamic models of age-structured cell populations
Wojciech Krzyzanski
Original Paper 16 September 2015 Pages: 573 - 589