1. Development of a physiologically based pharmacokinetic model for a domain antibody in mice using the two-pore theory

   • Armin Sepp
   • Alienor Berges
   • Guy Meno-Tetang

   Original Paper 11 January 2015 Pages: 97 - 109

   

2. Pharmacokinetics and pharmacodynamics of propofol in cancer patients undergoing major lung surgery

   • Krzysztof Przybyłowski
   • Joanna Tyczka
   • Edmund Grześkowiak

   Original Paper Open access 28 January 2015 Pages: 111 - 122

   

3. Usefulness of permutation entropy as an anesthetic depth indicator in children

   • Pil-Jong Kim
   • Hong-Gee Kim
   • Teo Jeon Shin

   Original Paper 04 February 2015 Pages: 123 - 134

   

4. A PBPK workflow for first-in-human dose selection of a subcutaneously administered pegylated peptide

   • Elliot Offman
   • Andrea N. Edginton

   Original Paper 04 February 2015 Pages: 135 - 150

   

5. Closed form solutions and dominant elimination pathways of simultaneous first-order and Michaelis–Menten kinetics

   • Xiaotian Wu
   • Jun Li
   • Fahima Nekka

   Original Paper 13 February 2015 Pages: 151 - 161

   

6. Population pharmacokinetic and pharmacodynamic model of propofol externally validated in children

   • Byung-Moon Choi
   • Hyun-Gu Lee
   • Gyu-Jeong Noh

   Original Paper 28 February 2015 Pages: 163 - 177

   

7. Integrated PK-PD and agent-based modeling in oncology

   • Zhihui Wang
   • Joseph D. Butner
   • Thomas S. Deisboeck

   Review Paper 15 January 2015 Pages: 179 - 189