1. Announcement

   OriginalPaper 07 November 2005 Pages: 155 - 155

2. Editorial to the First Issue Dedicated to Lewis Sheiner

   OriginalPaper 07 November 2005 Pages: 157 - 159

3. Non-Linear Mixed Effects Modeling – From Methodology and Software Development to Driving Implementation in Drug Development Science

   • Goonaseelan (Colin) Pillai
   • France Mentré
   • Jean-Louis Steimer

   OriginalPaper 07 November 2005 Pages: 161 - 183

4. How Modeling and Simulation Have Enhanced Decision Making in New Drug Development

   • Raymond Miller
   • Wayne Ewy
   • Richard L. Lalonde

   OriginalPaper 07 November 2005 Pages: 185 - 197

5. Getting the Dose Right: Report From the Tenth European Federation of Pharmaceutical Sciences (EUFEPS) Conference on Optimizing Drug Development

   • Donald R. Stanski
   • Malcolm Rowland
   • Lewis B. Sheiner

   OriginalPaper 07 November 2005 Pages: 199 - 211

6. Conditioning on Certain Random Events Associated with Statistical Variability in PK/PD

   • Stuart L. Beal

   OriginalPaper 07 November 2005 Pages: 213 - 243

7. Mixed Effects versus Fixed Effects Modelling of Binary Data with Inter-subject Variability

   • Valda Murphy
   • Adrian Dunne

   OriginalPaper 07 November 2005 Pages: 245 - 260

8. Modelling a Spontaneously Reported Side Effect by Use of a Markov Mixed-Effects Model

   • Per-Henrik Zingmark
   • Matts Kågedal
   • Mats O Karlsson

   OriginalPaper 07 November 2005 Pages: 261 - 281

9. Analyzing Multi-Response Data Using Forcing Functions

   • Liping Zhang
   • Lewis B. Sheiner

   OriginalPaper 07 November 2005 Pages: 283 - 305