1. Physiological Modeling for Indirect Evaluation of Drug Tissular Pharmacokinetics under Non-Steady-State Conditions: An Example of Antimicrobial Prophylaxis During Liver Surgery

   • Franck Lagneau
   • Jean Marty
   • Michel Tod

   OriginalPaper Pages: 1 - 32

2. Robust Population Pharmacokinetic Experiment Design

   • Michael G. Dodds
   • Andrew C. Hooker
   • Paolo Vicini

   OriginalPaper Pages: 33 - 64

3. Control-Relevant Modeling of the Antitumor Effects of 9-Nitrocamptothecin in SCID Mice Bearing HT29 Human Colon Xenografts

   • John M. Harrold
   • Julie L. Eiseman
   • Robert S. Parker

   OriginalPaper Pages: 65 - 83

4. Non-Linear Mixed-Effects Models with Stochastic Differential Equations: Implementation of an Estimation Algorithm

   • Rune V. Overgaard
   • Niclas Jonsson
   • Henrik Madsen

   OriginalPaper Pages: 85 - 107

5. Using Stochastic Differential Equations for PK/PD Model Development

   • Niels Rode Kristensen
   • Henrik Madsen
   • Steen Hvass Ingwersen

   OriginalPaper Pages: 109 - 141

6. Improving Pharmacokinetic–Pharmacodynamic Models of Muscle Relaxants Using Potentiation Modelling

   • Douglas J. Eleveld
   • Johannes H. Proost
   • J. Mark K. H. Wierda

   OriginalPaper Pages: 143 - 154