1. Challenges of fragment screening

   • Diane Joseph-McCarthy

   Guest Editorial 30 June 2009 Pages: 449 - 451

2. Fragment-based drug discovery

   • Wendy A. Warr

   Warr's Piece 24 June 2009 Pages: 453 - 458

3. The multiple roles of computational chemistry in fragment-based drug design

   • Richard Law
   • Oliver Barker
   • Mark Whittaker

   OriginalPaper 17 June 2009 Pages: 459 - 473

   

4. The multi-copy simultaneous search methodology: a fundamental tool for structure-based drug design

   • Christian R. Schubert
   • Collin M. Stultz

   OriginalPaper 09 June 2009 Pages: 475 - 489

   

5. Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase

   • Melissa R. Landon
   • Raquel L. Lieberman
   • Dagmar Ringe

   OriginalPaper 12 June 2009 Pages: 491 - 500

   

6. Fragment-based lead generation: identification of seed fragments by a highly efficient fragment screening technology

   • Lars Neumann
   • Allegra Ritscher
   • Doris Hafenbradl

   OriginalPaper 17 June 2009 Pages: 501 - 511

   

7. Design of compound libraries for fragment screening

   • Niklas Blomberg
   • David A. Cosgrove
   • Karin Kolmodin

   OriginalPaper 13 March 2009 Pages: 513 - 525

   

8. Virtual fragment screening: an exploration of various docking and scoring protocols for fragments using Glide

   • Sameer Kawatkar
   • Hongming Wang
   • Diane Joseph-McCarthy

   OriginalPaper 03 June 2009 Pages: 527 - 539

   

9. Energetic analysis of fragment docking and application to structure-based pharmacophore hypothesis generation

   • Kathryn Loving
   • Noeris K. Salam
   • Woody Sherman

   OriginalPaper 07 May 2009 Pages: 541 - 554

   

10. Development and NMR validation of minimal pharmacophore hypotheses for the generation of fragment libraries enriched in heparanase inhibitors

    • Rafael Gozalbes
    • Silvia Mosulén
    • Antonio Pineda-Lucena

    OriginalPaper 07 May 2009 Pages: 555 - 569

    

11. Computational fragment-based drug design to explore the hydrophobic sub-pocket of the mitotic kinesin Eg5 allosteric binding site

    • Ksenia Oguievetskaia
    • Laetitia Martin-Chanas
    • Fabrice Moriaud

    OriginalPaper 17 June 2009 Pages: 571 - 582

    

12. Structural models in the assessment of protein druggability based on HTS data

    • Anvita Gupta
    • Arun Kumar Gupta
    • Kothandaraman Seshadri

    OriginalPaper 29 May 2009 Pages: 583 - 592

    

13. Second-generation de novo design: a view from a medicinal chemist perspective

    • Andrea Zaliani
    • Krisztina Boda
    • Matthias Rarey

    OriginalPaper 27 June 2009 Pages: 593 - 602

    

14. Lessons for fragment library design: analysis of output from multiple screening campaigns

    • I-Jen Chen
    • Roderick E. Hubbard

    OriginalPaper 03 June 2009 Pages: 603 - 620