1. Preface

   • Michael R. Rose
   • Caleb E. Finch

   EditorialNotes Pages: 1 - 1

2. The janiform genetics of aging

   • Michael R. Rose
   • Caleb E. Finch

   OriginalPaper Pages: 3 - 10

3. Evolutionary mechanisms of senescence

   • Brian Charlesworth

   OriginalPaper Pages: 11 - 19

4. Pathogen evolution within host individuals as a primary cause of senescence

   • Graham Bell

   OriginalPaper Pages: 21 - 34

5. The genetics of aging in the yeastSaccharomyces cerevisiae

   • S. Michal Jazwinski

   OriginalPaper Pages: 35 - 51

6. Evolutionary senescence in plants

   • Deborah Ann Roach

   OriginalPaper Pages: 53 - 64

7. Comparing mutants, selective breeding, and transgenics in the dissection of aging processes ofCaenorhabditis elegans

   • Thomas E. Johnson
   • Patricia M. Tedesco
   • Gordon J. Lithgow

   OriginalPaper Pages: 65 - 77

8. New model systems for studying the evolutionary biology of aging: Crustacea

   • David Reznick

   OriginalPaper Pages: 79 - 88

9. Evolution of aging: Testing the theory usingDrosophila

   • L. Partridge
   • N. H. Barton

   OriginalPaper Pages: 89 - 98

10. Population density effects on longevity

    • Joseph L. Graves Jr.
    • Laurence D. Mueller

    OriginalPaper Pages: 99 - 109

11. Evolution of delayed reproductive senescence in male fruit flies: Sperm competition

    • Philip M. Service
    • Amanda J. Fales

    OriginalPaper Pages: 111 - 125

12. Genetic and environmental factors regulating the expression of an extended longevity phenotype in a long lived strain ofDrosophila

    • Robert Arking
    • Steven P. Dudas
    • George T. Baker III

    OriginalPaper Pages: 127 - 142

13. The effect of superoxide dismutase alleles on aging inDrosophila

    • Robert H. Tyler
    • Hardip Brar
    • Francisco J. Ayala

    OriginalPaper Pages: 143 - 149

14. Use of recombinant inbred strains to map genes of aging

    • Linda K. Dixon

    OriginalPaper Pages: 151 - 165

15. The effects of enhanced expression of elongation factor EF-1α on lifespan inDrosophila melanogaster

    • Stephen C. Stearns
    • Marcel Kaiser

    OriginalPaper Pages: 167 - 182

16. Two-dimensional protein electrophoretic analysis of postponed aging inDrosophila

    • James E. Fleming
    • Greg S. Spicer
    • Michael R. Rose

    OriginalPaper Pages: 183 - 198

17. Genetic control of retroviral disease in aging wild mice

    • Murray B. Gardner

    OriginalPaper Pages: 199 - 209

18. Genetics of life span in mice

    • E. J. Yunis
    • M. Salazar

    OriginalPaper Pages: 211 - 223

19. Genes of the major histocompatibility complex and the evolutionary genetics of lifespan

    • Mark D. Crew

    OriginalPaper Pages: 225 - 238

20. Genetic influences on glucose neurotoxicity, aging, and diabetes: A possible role for glucose hysteresis

    • Charles V. Mobbs

    OriginalPaper Pages: 239 - 253

21. Genetic heterogeneity of gene defects responsible for familial Alzheimer disease

    • Rudolph Tanzi
    • Sandra Gaston
    • Wilma Wasco

    OriginalPaper Pages: 255 - 263

22. Abiotrophic gene action inHomo sapiens: Potential mechanisms and significance for the pathobiology of aging

    • George M. Martin

    OriginalPaper Pages: 265 - 277

23. Antagonistic pleiotropy, mutation accumulation, and human genetic disease

    • Roger L. Albin

    OriginalPaper Pages: 279 - 286