1. Introduction

   • F. P. Brooks
   • G. Watkinson
   • H. C. Davies

   EditorialNotes Pages: 5S - 5S

2. Peptic ulcer disease

   • G. Watkinson
   • F. P. Brooks

   OriginalPaper Pages: 6S - 7S

3. Changing demographics of peptic ulcer disease

   • O. Bonnevie

   Part 1: Peptic Ulcer Disease: Clinical Implications Pages: 8S - 14S

4. The pathophysiology of peptic ulcer disease

   • F. P. Brooks

   Part 1: Peptic Ulcer Disease: Clinical Implications Pages: 15S - 29S

5. Current diagnosis and selection of patients for treatment of peptic ulcer disease

   • R. Gugler

   Part 1: Peptic Ulcer Disease: Clinical Implications Pages: 30S - 35S

6. Anti-ulcer therapy

   • A. Bettarello

   Part 1: Peptic Ulcer Disease: Clinical Implications Pages: 36S - 42S

7. Pharmacology of the treatment of peptic ulcer disease

   • G. Bertaccini
   • G. Coruzzi

   Part 1: Peptic Ulcer Disease: Clinical Implications Pages: 43S - 51S

8. The surgical treatment of peptic ulcer disease

   • J-P. Bader

   Part 1: Peptic Ulcer Disease: Clinical Implications Pages: 52S - 54S

9. Adherent and soluble mucus in the stomach and duodenum

   • A. Allen
   • N. J. H. Carroll

   Part 2: The Gastric Mucosal Barrier Pages: 55S - 62S

10. Gastroduodenal bicarbonate secretion in mucosal protection

    • G. Flemström
    • E. Kivilaakso
    • G. Jedstedt

    Part 2: The Gastric Mucosal Barrier Pages: 63S - 68S

11. The gastric mucosal barrier

    • Gordon L. Kauffman Jr.

    Part 2: The Gastric Mucosal Barrier Pages: 69S - 76S

12. Gastric blood flow and the gastric mucosal barrier

    • Eugene D. Jacobson

    Part 2: The Gastric Mucosal Barrier Pages: 77S - 80S

13. Overview of clinical cytoprotection

    • Jon I. Isenberg

    Part 3: Role of Prostaglandins in Mucosal Cytoprotection in Health and Disease Pages: 81S - 82S

14. Prostaglandins and histological changes in the gastric mucosa

    • Eric R. Lacy

    Part 3: Role of Prostaglandins in Mucosal Cytoprotection in Health and Disease Pages: 83S - 94S

15. Ultrastructural effects of ulcerogens

    • Gregory L. Eastwood

    Part 3: Role of Prostaglandins in Mucosal Cytoprotection in Health and Disease Pages: 95S - 104S

16. Prostaglandins in pathophysiology of peptic ulcer disease

    • S. J. Konturek

    Part 3: Role of Prostaglandins in Mucosal Cytoprotection in Health and Disease Pages: 105S - 108S

17. Prostaglandins as hormones

    • N. Shimizu
    • T. Nakamura

    Part 3: Role of Prostaglandins in Mucosal Cytoprotection in Health and Disease Pages: 109S - 113S

18. Chemistry and synthetic development of misoprostol

    • P. W. Collins
    • R. Pappo
    • E. Z. Dajani

    Part 4: Clinical and Pharmacological Actions of Misoprostol, a PGE1 Analog Pages: 114S - 117S

19. Misoprostol preclinical pharmacology

    • R. F. Bauer

    Part 4: Clinical and Pharmacological Actions of Misoprostol, a PGE1 Analog Pages: 118S - 125S

20. Metabolism and pharmacokinetic studies of misoprostol

    • G. Schoenhard
    • J. Oppermann
    • F. E. Kohn

    Part 4: Clinical and Pharmacological Actions of Misoprostol, a PGE1 Analog Pages: 126S - 128S

21. Gastric morphology in ulcer patients receiving misoprostol

    • Bernard M. Wagner

    Part 4: Clinical and Pharmacological Actions of Misoprostol, a PGE1 Analog Pages: 129S - 132S

22. Effect of misoprostol and cimetidine on gastric cell turnover

    • A. Fich
    • N. Arber
    • D. Rachmilewitz

    Part 4: Clinical and Pharmacological Actions of Misoprostol, a PGE1 Analog Pages: 133S - 135S

23. Misoprostol clinical pharmacology

    • J. A. Steiner

    Part 4: Clinical and Pharmacological Actions of Misoprostol, a PGE1 Analog Pages: 136S - 141S

24. Preclinical toxicology profile of misoprostol

    • F. N. Kotsonis
    • D. C. Dodd
    • F. E. Kohn

    Part 4: Clinical and Pharmacological Actions of Misoprostol, a PGE1 Analog Pages: 142S - 146S

25. Misoprostol, a synthetic PGE₁ analog, in the treatment of duodenal ulcers

    • D. L. Brand
    • W. M. Roufall
    • E. J. Tapper

    Part 4: Clinical and Pharmacological Actions of Misoprostol, a PGE1 Analog Pages: 147S - 158S

26. Misoprostol in the treatment of duodenal ulcer

    • S. J. Sontag
    • P. A. Mazure
    • E. Z. Dajani

    Part 4: Clinical and Pharmacological Actions of Misoprostol, a PGE1 Analog Pages: 159S - 163S

27. Healing of benign gastric ulcer

    • N. M. Agrawal
    • B. Saffouri
    • E. Z. Dajani

    Part 4: Clinical and Pharmacological Actions of Misoprostol, a PGE1 Analog Pages: 164S - 170S

28. A multicenter international controlled comparison of two dosage regimes of misoprostol and cimetidine in the treatment of duodenal ulcer in out-patients

    • P. A. Nicholson

    Part 4: Clinical and Pharmacological Actions of Misoprostol, a PGE1 Analog Pages: 171S - 177S

29. Interim results of a multicenter international comparison of misoprostol and cimetidine in the treatment of out-patients with benign gastric ulcers

    • M. J. Shield

    Part 4: Clinical and Pharmacological Actions of Misoprostol, a PGE1 Analog Pages: 178S - 184S

30. Overview of clinical safety with misoprostol

    • R. L. Herting
    • G. A. Clay

    Part 4: Clinical and Pharmacological Actions of Misoprostol, a PGE1 Analog Pages: 185S - 193S

31. Gastrointestinal cytoprotective effects of misoprostol

    • Esam Z. Dajani
    • Catherine H. Nissen

    Part 4: Clinical and Pharmacological Actions of Misoprostol, a PGE1 Analog Pages: 194S - 200S

32. Prostaglandins and chemotherapy-induced ulcers in dogs

    • P. Bright-Asare
    • I. Giannikopoulos
    • J. T. Whiten

    Part 4: Clinical and Pharmacological Actions of Misoprostol, a PGE1 Analog Pages: 201S - 203S

33. Summary

    • F. P. Brooks
    • G. Watkinson

    Part 4: Clinical and Pharmacological Actions of Misoprostol, a PGE1 Analog Pages: 204S - 205S