1. P-glycoprotein structure and evolutionary homologies

   • Irene Bosch
   • James M. Croop

   OriginalPaper Pages: 1 - 30

2. Introduction

   • Martin Clynes

   OriginalPaper Pages: 7 - 7

3. Dedication

   OriginalPaper Pages: 9 - 9

4. Acknowledgement

   OriginalPaper Pages: 11 - 11

5. Molecular analysis of the multidrug transporter, P-glycoprotein

   • Ursula A. Germann
   • Timothy C. Chambers

   OriginalPaper Pages: 31 - 60

6. Mutagenesis of the putative nucleotide-binding domains of the multidrug resistance associated protein (MRP). Analysis of the effect of these mutations on MRP mediated drug resistance and transport

   • Melvin S. Center
   • Qichao Zhu
   • Hongwei Sun

   OriginalPaper Pages: 61 - 69

7. Membrane topology of the human multidrug resistance-associated protein (MRP) and its homologs

   • András Váradi
   • Gábor E. Tusnády
   • Balázs Sarkadi

   OriginalPaper Pages: 71 - 79

8. A new aspect on glutathione-associated biological function of MRP/GS-X pump and its gene expression

   • Toshihisa Ishikawa
   • M. Tien Kuo
   • Masaaki Suzuki

   OriginalPaper Pages: 81 - 93

9. Intracellular distribution of anthracyclines in drug resistant cells

   • Giuseppe Arancia
   • Annarica Calcabrini
   • Agnese Molinari

   OriginalPaper Pages: 95 - 111

10. Use of ribozymes and antisense oligodeoxynucleotides to investigate mechanisms of drug resistance

    • Daragh Byrne
    • Carmel Daly
    • Martin Clynes

    OriginalPaper Pages: 113 - 136

11. Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP

    • Miguel A. Izquierdo
    • George L. Scheffer
    • Rik J. Scheper

    OriginalPaper Pages: 137 - 148

12. Topoisomerase I inhibitors and drug resistance

    • Ralph E. Parchment
    • Augusto Pessina

    OriginalPaper Pages: 149 - 164

13. Mechanisms of resistance to alkylating agents

    • G. Damia
    • M. D‘Incalci

    OriginalPaper Pages: 165 - 173

14. Drug resistance and DNA repair in leukaemia

    • Mark R. Müller
    • Jürgen Thomale
    • Siegfried Seeber

    OriginalPaper Pages: 175 - 185

15. Nucleotide excision repair and anti-cancer chemotherapy

    • Eddie Reed

    OriginalPaper Pages: 187 - 201

16. Protein kinases and multidrug resistance

    • Martin G. Rumsby
    • Lisa Drew
    • J. Roger Warr

    OriginalPaper Pages: 203 - 224

17. New insights into the kinetic resistance to anticancer agents

    • Bruno Chauffert
    • Marie-Thérèse Dimanche-Boitrel
    • Eric Solary

    OriginalPaper Pages: 225 - 235

18. The extended-MDR phenotype

    • Ross Davey
    • Mary Davey

    OriginalPaper Pages: 237 - 247

19. Role of oxygenation and vascularization in drug resistance

    • Jürgen Mattern
    • Manfred Volm

    OriginalPaper Pages: 249 - 256

20. Transcriptional regulation of MDR genes

    • Kathleen W. Scotto
    • David A. Egan

    OriginalPaper Pages: 257 - 269

21. Cytokine-mediated reversal of multidrug resistance

    • Ulrike Stein
    • Wolfgang Walther

    OriginalPaper Pages: 271 - 282

22. The role of oncogenes in drug resistance

    • Dihua Yu

    OriginalPaper Pages: 283 - 292

23. Apoptosis resistance in tumor cells

    • Tetsuo Mashima
    • Hiroyuki Seimiya
    • Takashi Tsuruo

    OriginalPaper Pages: 293 - 308

24. Regulation of caspase activation in apoptosis: implications for transformation and drug resistance

    • Elizabeth A. Slee
    • Seamus J. Martin

    OriginalPaper Pages: 309 - 320

25. Regulation of keratin and integrin gene expression in cancer and drug resistance

    • Noel Daly
    • Paula Meleady
    • Martin Clynes

    OriginalPaper Pages: 321 - 344

26. Instructions to Authors

    OriginalPaper Pages: 345 - 348