Abstract
Bone morphogenetic proteins (BMPs) are the largest subfamily of the transforming growth factor-β superfamily, and they play important roles in the development of numerous organs, including the inner ear. The inner ear is a relatively small organ but has a highly complex structure and is involved in both hearing and balance. Here, we discuss BMPs and BMP signaling pathways and then focus on the role of BMP signal pathway regulation in the development of the inner ear and the implications this has for the treatment of human hearing loss and balance dysfunction.
摘要
骨形态发生蛋白(BMP)是转化生长因子-β 超家族中最大的亚家族, 它们在许多器官(包括内耳) 的发育中发挥重要作用。 内耳是一个较小的器官, 但其具有非常复杂的结构并且与听觉和平衡相关。 本文先着重于 BMPs 及其 BMP 信号通路的介绍, 后以内耳的发育时间为轴线, 配合图片, 介绍了 BMP 信号通路在内耳发育的不同阶段的影响以及对于内耳的不同部位的发育的影响, 并概括了最新的内耳发育领域关于 BMP 信号通路的研究, 为之后的内耳发育以及毛细胞再生的研究提供参考。
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Ma, Jy., You, D., Li, Wy. et al. Bone morphogenetic proteins and inner ear development. J. Zhejiang Univ. Sci. B 20, 131–145 (2019). https://doi.org/10.1631/jzus.B1800084
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DOI: https://doi.org/10.1631/jzus.B1800084