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Photothermal treatment of human carcinoma cells using liposome-encapsulated gold nanoshells

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NanoBiotechnology

Abstract

We report the application of liposome-encapsulated gold nanoshells for in vitro photo-induced hyperthermia in human mammary carcinoma cells. In addition to evaluating their effects in vitro, we compared the application liposome-encapsulated gold nanoshells and free-standing gold nanoshells for NanoPhotoTherapy (NPT). NPT-induced hyperthermia was performed using a 785-nm near-infrared light from a diode laser and the in vitro effects were evaluated using nucleic acid molecular probes by fluorescence microscopy. Additionally, we monitored the effectiveness of NPT by detecting apoptosis via capase-9 activity.

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Authors and Affiliations

  1. Advanced Biomedical Science & Technology Group, Oak Ridge National Laboratory, 37831, Oak Ridge, TN

    Paul M. Kasili & Tuan Vo-Dinh

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  1. Paul M. Kasili
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  2. Tuan Vo-Dinh
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Correspondence to Tuan Vo-Dinh.

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Kasili, P.M., Vo-Dinh, T. Photothermal treatment of human carcinoma cells using liposome-encapsulated gold nanoshells. Nanobiotechnol 1, 245–252 (2005). https://doi.org/10.1385/NBT:1:3:245

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