Abstract
In order to be effective, electrochemotherapy must meet the following two requirements. First, the chemotherapeutic drug must be present around tumor cells, and second, each cell in the tumor must be exposed to an electric field that is above the threshold value for this particular tumor type.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsSpringer Nature is developing a new tool to find and evaluate Protocols. Learn more
References
Mir, L. M., Orlowski, S., Belehradek, J. Jr., Teissié, J., Rols, M. P., Serša, G., Miklavčič, D., Gilbert, R., and Heller, R. (1995) Biomedical application of electric pulses with special emphasis on antitumor electrochemotherapy. Bioelectrochem. Bioenerg. 38, 203–207.
Mir, L. M., Orlowski, S., Belehradek, J. Jr., and Paoletti, C. (1991) Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses. Eur. J. Cancer 27, 68–72.
Belehradek, J. Jr., Orlowski, S., Poddevin, B., Paoletti, C., and Mir, L. M. (1991) Electrochemotherapy of spontaneous tumors in mice. Eur. J. Cancer 27, 73–76.
Serša, G., Čemažar, M., Miklavčič, D., and Mir, L. M. (1994) Electrochemotherapy: Variable anti-tumor effect on different tumor models. Bioelectrochem. Bioenerg. 35, 23–27.
Heller, R., Jaroszeski, M., Leo-Messina, J., Perrot, R., Van Voorhis, N., Reintgen, D., and Gilbert, R. (1995) Treatment of B16 mouse melanoma with the combination of electropermeabilization and chemotherapy. Bioelectrochem. Bioenerg. 36, 83–87.
Čemažar, M., Miklavčič, D., Vodovnik, L., Jarm, T., Rudolf, Z., Štabuc, B., Čufer, T., and Serša, G. (1995) Improved therapeutic effect of electrochemotherapy with cisplatin by intratumoral drug administration and changing of electrode orientation for electropermeabilization of EAT tumor model in mice. Radiol. Oncol. 29, 121–127.
Serša, G., Čemažar, M., Šemrov, D., and Miklavčič, D. (1996) Changing electrode orientation improves the efficacy of electrochemotherapy of solid tumors in mice. Bioelectrochem. Bioenerg. 39, 61–66.
Suit, H. D., Sedlacek, R., and Thames, H. D. Jr. (1987) Radiation dose-response assays of tumor control. Rodent Tumor Models in Experimental Cancer Therapy (Kallman, R. F., ed.), Pergamon Press, New York, pp. 114–121.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Humana Press Inc.
About this protocol
Cite this protocol
Čemažar, M. (2000). Treatment of a Tumor Model with ECT Using 4+4 Electrode Configuration. In: Jaroszeski, M.J., Heller, R., Gilbert, R. (eds) Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery. Methods in Molecular Medicine, vol 37. Humana Press. https://doi.org/10.1385/1-59259-080-2:259
Download citation
DOI: https://doi.org/10.1385/1-59259-080-2:259
Publisher Name: Humana Press
Print ISBN: 978-0-89603-606-2
Online ISBN: 978-1-59259-080-3
eBook Packages: Springer Protocols