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Tissue Engineering Methods and Protocols pp 595–605Cite as

Quantitative Modeling of Limitations Caused by Diffusion

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Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 18))

Abstract

Transport of nutrients and metabolites in many bioartificial tissue constructs relies exclusively on diffusion, i.e., on the presence of a concentration gradient between the inside of the construct and the surrounding milieu. A quantitative evaluation of the rate of diffusional processes is thus essential for properly designing three-dimensional cell-polymer systems, and for assessing the chemical environment at various locales within the construct.

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Author information

Authors and Affiliations

  1. School of Chemical Engineering and Parker H.Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA

    Athanassios Sambanis & Sanda A. Tan

Authors
  1. Athanassios Sambanis
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  2. Sanda A. Tan
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Editor information

Editors and Affiliations

  1. Center for Engineering in Medicine, Massachusetts General Hospital/Harvard Medical School, Boston, MA

    Jeffrey R. Morgan PhD  & Martin L. Yarmush MD  & 

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© 1999 Humana Press Inc., Totowa, NJ

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Sambanis, A., Tan, S.A. (1999). Quantitative Modeling of Limitations Caused by Diffusion. In: Morgan, J.R., Yarmush, M.L. (eds) Tissue Engineering Methods and Protocols. Methods in Molecular Medicine™, vol 18. Humana Press. https://doi.org/10.1385/0-89603-516-6:595

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  • DOI: https://doi.org/10.1385/0-89603-516-6:595

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-516-4

  • Online ISBN: 978-1-59259-602-7

  • eBook Packages: Springer Protocols

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