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Multiple and Combinatorial Peptide Synthesis

Chemical Development and Biological Applications

  • Protocol
Peptide Analysis Protocols

Part of the book series: Methods in Molecular Biology ((MIMB,volume 36))

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Abstract

The rapid synthesis of peptides to support both exploratory peptide lead discovery and analog structure-activity studies has been the subject of intense research and technology development over the past few years (1– 4). Two general approaches have been advanced that may be classified as follows: (1) multiple peptide synthesis (MPS) and (2) combinatorial peptide synthesis (CPS). The peptide chemistry aspect of such multiple or combinatorial approaches typically integrates experimental methodologies that have been well established to date for the preparation of single peptides by solid-phase techniques. However, there exist novel and, in some cases, proprietary chemistry methods and/or materials that are essential to each of these approaches (vide infra). A common objective of the multiple or combinatorial approaches is to expedite the process and quantitative scope of synthetic peptide production in a manner that interfaces well with biological testing.

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Author information

Authors and Affiliations

  1. Department of Biological Chemistry, University of Michigan, Ann Arbor, MI

    Philip C. Andrews

  2. Department of Chemistry, Parke-Davis Pharmaceutical Research, Warner-Lambert Co., Ann Arbor, MI

    Daniele M. Leonard, Wayne L. Cody & Tomi K. Sawyer

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  1. Philip C. Andrews
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  2. Daniele M. Leonard
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  3. Wayne L. Cody
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  4. Tomi K. Sawyer
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Editors and Affiliations

  1. University of Florida, Gainesville, FL

    Ben M. Dunn

  2. Bachem Bioscience, King of Prussia, PA

    Michael W. Pennington

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© 1994 Humana Press Inc., Totowa, NJ

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Andrews, P.C., Leonard, D.M., Cody, W.L., Sawyer, T.K. (1994). Multiple and Combinatorial Peptide Synthesis. In: Dunn, B.M., Pennington, M.W. (eds) Peptide Analysis Protocols. Methods in Molecular Biology, vol 36. Humana Press. https://doi.org/10.1385/0-89603-274-4:305

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  • DOI: https://doi.org/10.1385/0-89603-274-4:305

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-274-3

  • Online ISBN: 978-1-59259-523-5

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