Abstract
Rojas and colleagues have presented an exciting paper demonstrating yet another relevant preclinical setting in which the mesenchymal stromal cell has a potential therapeutic application. What is particularly interesting about this study is that it addresses a disease, blood-borne systemic sepsis, which has multiple complex host responses and involves a variety of disparate organs and immune cell types. Here, the authors focus on how this injury relates more specifically to the lung, with quite dramatic improvements in several assessed injury parameters. Where does this latest demonstration of mesenchymal stromal cell efficacy leave us with regard to getting these cell therapies to the acute respiratory distress syndrome patient?
Abbreviations
- ARDS:
-
Acute respiratory distress syndrome
- MSC:
-
Mesenchymal stromal cell.
References
Rojas M, Cárdenes N, Kocyildirim E, Tedrow JR, Romagnoli MR, Cáceres E, Dean R, Ting A, Bermúdez C: Human adult bone marrow-derived stem cells decrease severity of LPS-induced acute respiratory distress syndrome in sheep. Stem Cell Res Ther. 2014, 5: 42-10.1186/scrt430.
Haack-Sorensen M, Bindslev L, Mortensen S, Friis T, Kastrup J: The influence of freezing and storage on the characteristics and functions of human mesenchymal stromal cells isolated for clinical use. Cytotherapy. 2007, 9: 328-337. 10.1080/14653240701322235.
François M, Copland IB, Yuan S, Romieu-Mourez R, Waller EK, Galipeau J: Cryopreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-γ licensing. Cytotherapy. 2012, 14: 147-152. 10.3109/14653249.2011.623691.
Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay MA: Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Stem Cells. 2010, 28: 2229-2238. 10.1002/stem.544.
Mei SH, Haitsma JJ, Dos Santos CC, Deng Y, Lai PF, Slutsky AS, Liles WC, Stewart DJ: Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis. Am J Respir Crit Care Med. 2010, 182: 1047-1057. 10.1164/rccm.201001-0010OC.
Acknowledgements
The authors are supported by The Health Research Board Ireland, Science Foundation Ireland and the European Research Council FP7 program.
Author information
Authors and Affiliations
Corresponding author
Additional information
Competing interests
The authors declare that they have no competing interests.
Authors’ contributions
The authors contributed equally to the preparation, writing and proofreading of this manuscript. Both authors read and approved the final manuscript.
Rights and permissions
About this article
Cite this article
Masterson, C., O’Toole, D. The mesenchymal stromal cell magic bullet finds yet another target. Stem Cell Res Ther 5, 82 (2014). https://doi.org/10.1186/scrt471
Published:
DOI: https://doi.org/10.1186/scrt471