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Polymorphic repeat in AIB1 does not alter breast cancer risk

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Statement of findings

We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort. We observed no association between AIB1 genotype and breast cancer incidence, or specific tumor characteristics. These findings suggest that AIB1 repeat genotype does not influence postmenopausal breast cancer risk among Caucasian women in the general population.

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Acknowledgements

We thank Mr Robert O' Brien, Mrs Lisa Li, Mrs Barbara Egan, Mrs Jeanne Sparrow, Mr Tim Shepard and Dr Phillip Kantoff for their technical assistance. We are also indebted to the participants of the Nurses' Health Study for their dedication and commitment. This work is supported by NIH grants CA40356, CA49449 and CA65725. David Hunter is partially supported by an ACS Faculty Research Award, FRA-455, and Myles Brown by NIH grant CA57374.

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Authors and Affiliations

  1. Channing Laboratory, Harvard School of Public Health, 181 Longwood Avenue, Boston, Massachusetts, 02115, USA

    Christopher A Haiman & Donna Spiegelman

  2. Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Susan E Hankinson, Graham A Colditz, Walter C Willett, Frank E Speizer & David J Hunter

  3. Dana-Farber Cancer Institute, Boston, Massachusetts, USA

    Myles Brown

Authors
  1. Christopher A Haiman
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  2. Susan E Hankinson
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  3. Donna Spiegelman
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  4. Graham A Colditz
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  5. Walter C Willett
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  6. Frank E Speizer
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  7. Myles Brown
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  8. David J Hunter
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Correspondence to Christopher A Haiman.

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Haiman, C.A., Hankinson, S.E., Spiegelman, D. et al. Polymorphic repeat in AIB1 does not alter breast cancer risk. Breast Cancer Res 2, 378 (2000). https://doi.org/10.1186/bcr82

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  • DOI: https://doi.org/10.1186/bcr82

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