Abstract
Alkylation of fluorophenols and phenolic aldehydes with 5-phenyl(p-tolyl)-3-chloromethylisoxazole under the Williamson reaction conditions afforded the corresponding ethers. Condensation of the resulting phenolic aldehyde derivatives and 5-phenyl(p-tolyl)isoxazole-3-carbaldehydes with p-fluoroaniline resulted in fluorine-containing azomethines. Acylation of fluorinated amines with 5-(p-tolyl)isoxazole- and 4,5- dichloroisothiazole-3-carbonyl chlorides gave rise to fluorinated amides bearing isoxazole and isothiazole fragments, representatives of which showed a synergistic effect in compositions with insecticides.
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Original Russian Text © S.K. Petkevich, E.A. Dikusar, A.V. Kletskov, I.B. Rozenzveig, G.G. Levkovskaya, P.V. Kurman, R.M. Zolotar’, V.I. Potkin, 2018, published in Zhurnal Obshchei Khimii, 2018, Vol. 88, No. 2, pp. 255–261.
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Petkevich, S.K., Dikusar, E.A., Kletskov, A.V. et al. Synthesis of Fluorine-Containing Derivatives of 5-Arylisoxazoles and 4,5-Dichlorothiazole. Russ J Gen Chem 88, 234–240 (2018). https://doi.org/10.1134/S1070363218020081
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DOI: https://doi.org/10.1134/S1070363218020081