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Synthesis and antimicrobial activity of 6-aryl-3,4-dimethyl-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides

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Abstract

Three-component reaction of acetoacetanilide, aromatic aldehydes, and N-methylurea afforded 6-aryl-3,4-dimethyl-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. IR, 1H NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis data confirmed the structure of the compounds obtained. Antimicrobial activity of these compounds was investigated.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation, ul. Polevaya 2, Perm, 614990, Russia

    T. M. Zamaraeva, T. F. Odegova, A. Yu. Fedotov, M. V. Tomilov & V. L. Gein

  2. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, Yekaterinburg, Russia

    P. A. Slepukhin

  3. B.N. Yeltsin Ural Federal University, Yekaterinburg, Russia

    P. A. Slepukhin

Authors
  1. T. M. Zamaraeva
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  2. T. F. Odegova
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  3. A. Yu. Fedotov
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  4. M. V. Tomilov
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  5. V. L. Gein
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  6. P. A. Slepukhin
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Corresponding author

Correspondence to V. L. Gein.

Additional information

Original Russian Text © T.M. Zamaraeva, T.F. Odegova, A.Yu. Fedotov, M.V. Tomilov, V.L. Gein, P.A. Slepukhin, 2014, published in Zhurnal Obshchei Khimii, 2014, Vol. 84, No. 10, pp. 1672–1675.

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Zamaraeva, T.M., Odegova, T.F., Fedotov, A.Y. et al. Synthesis and antimicrobial activity of 6-aryl-3,4-dimethyl-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. Russ J Gen Chem 84, 1950–1952 (2014). https://doi.org/10.1134/S1070363214100168

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  • DOI: https://doi.org/10.1134/S1070363214100168

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