Abstract
4,5-Bis(hydroxy)-4-trifluoromethyl-6-(fluoroalkyl)hexahydropyrimidin-2-ones (thiones) have been obtained for the first time by the reaction of ureas (thioureas) with di(fluoroalkyl)-substituted 1,3-diketones and tetraols, the dehydration of which gave 2-hydroxy(mercapto)-4-trifluoromethyl-6-(fluoroalkyl)pyrimidines.
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Kuzueva, O.G., Burgart, Y.V., Saloutin, V.I. et al. First Example of the Synthesis of Di(fluoroalkyl)-substituted Pyrimidines. Chemistry of Heterocyclic Compounds 37, 1130–1135 (2001). https://doi.org/10.1023/A:1013235901570
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DOI: https://doi.org/10.1023/A:1013235901570