Abstract
Purpose
The aim of the study was to compare the efficacy of oral lorazepam as night sedation and premedication with diazepam.
Methods
A prospective, randomized, and double-blind study was done in 50 healthy patients in each drug group. The impacted third molar impaction was taken as the study model. Study was carried out after giving bioequivalent doses of respective drugs for either side. All the patients were assessed for quality of sleep, sedation, recall of visual stimuli, cooperation shown by patient and recovery postoperatively.
Results
The study concluded that lorazepam showed more advantages than diazepam as well as patient’s preference and satisfaction. However, postoperative recovery with lorazepam was longer than diazepam.
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Notes
Sedation is the depression of the patients awareness to the external environment and also reduces the responsiveness to any such stimulation
References
Ustun Y, Gunduz M, Erdogan O, Benlidayi EM (2006) Dexmedetomidine versus midazolam in outpatient third molar surgery. J Oral Maxillofac Surg 64(9):1353–1358
Bennett J (2002) Discussion—remifentanil for use during conscious sedation in outpatient oral surgery. J Oral Maxillofac Surg 60:250
Long DH, Eltringham RJ (1977) Lorazepam as night sedation and premedication: a comparison with dichloralphenazone and papaveretum. Anaesthesia 32:649–653
Wilson J, Ellis FR (1973) Oral premedication with lorazepam: a comparison with heptabarbitone and diazepam. Br J Anaesth 45:738–744
Magbagbeola JAO (1974) A comparison of lorazepam and diazepam as oral premedication for surgery under regional anaesthesia. Br J Anaesth 46:449–451
Tornetta FJ (1965) Diazepam as pre anaesthetic medication—a double blind study. Anaesth Analg 44:449–452
Haslett WHK, Dundee JW (1968) Study of drugs given before anaesthesia. XIV: two benzodiazepine derivative-chlordiazepoxide and diazepam. Br J Anaesth 40:250–258
Dodson ME, Eastley RJ (1978) Comparative study of two long acting tranquillizers for oral premedication. Br J Anaesth 50:1059–1064
Peterson LJ (1998) Principles of management of impacted teeth. In: Peterson LJ, Elllis E III, Hupp JR (eds) Contemporary oral and maxillofacial surgery. Mosby, St Louis, pp 215–248
Buysse DJ, Reynolds CF, Monk TH (1989) The pittsburg sleep quality index—a new instrument for psychiatric practice and research. Psychiatry Res 28(2):192–213
Salmon FF, Mets B, James MF (1992) Intravenous sedation for ocular surgery under local anaesthesia. Br J Ophthalmol 76:598
Ramsay MA, Savege TM (1974) Controlled sedation with alphaxalone–alphadolone. Br Med J 2:656–659
Studd C, Eltringham RJ (1980) Lorazepam as night sedation and comparison premedication: a with diazepam. Anaesthesia 35(1):60–64
Parworth LP, Frost DE, Zuniga JR (1998) Propofol and fentanyl compared with midazolam and fentanyl during third molar surgery. J Oral Maxillofac Surg 56:447
Jensen AG, Moller JT, Lybecker H (1995) A random trial comparing recovery after midazolam alfentanil anaesthesia with and without reversal with flumazenil, and standardized neurolept anaesthesia for major gynecologic surgery. J Clinic Anesth 7:63
Paymaster NJ (1973) Lorazepam in anaesthesia. Curr Med Res Opin 1:317–322
Paymaster NJ (1973) Lorazepam as a preoperative medication. Anaesthesia 28:521–526
Hawitt JM, Barr AM (1978) Premedication with lorazepam for bronchoscopy under general anaesthesia. Br J Anaesth 50:1149–1154
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Sharma, V., Singh, A., Sharma, P. et al. Comparative Study Between Oral Lorazepam and Diazepam as Sedation in Oral and Maxillofacial Surgery. J. Maxillofac. Oral Surg. 18, 256–259 (2019). https://doi.org/10.1007/s12663-018-1096-1
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DOI: https://doi.org/10.1007/s12663-018-1096-1