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Bonelike®/PLGA hybrid materials for bone regeneration: Preparation route and physicochemical characterisation

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Abstract

Bonelike®/PLGA hybrid materials have been developed using γ-MPS as silane-coupling agent between the inorganic and organic phases for controlled drug delivery applications.

Silanization showed to be more effective when cyclohexane was used as a non-polar solvent (nP method) due to a chemical interaction between Bonelike®, and the silane film, while by using a 95/5 (V/V) methanol/water as a polar solvent (P method), a much thinner film was achieved.

Functional groups of PLGA, such as the carbonyl group (C=O), were identified using Raman and FTIR-ATR analysis and therefore these groups may be used to link therapeutic molecules. These novel hybrid materials prepared by combining silanization and post-hybridisation processes are expected to find use in medical applications of bone regeneration and as drug delivery carrier for therapeutic molecules.

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Authors and Affiliations

  1. INEB—Instituto de Engenharia Biomédica, Laboratório de Biomateriais, Rua do Campo Alegre, 823, 4150-180, Porto, Portugal

    J. M. Oliveira, M. A. Lopes & J. D. Santos

  2. FEUP—Faculdade de Engenharia da Universidade do Porto, DEMM, Rua Dr. Roberto Frias, 4200-465, Porto, Portugal

    J. M. Oliveira, M. A. Lopes & J. D. Santos

  3. NAIST—Nara Institute of Science and Technology, 8916-5 Takayama, 630-0192, Ikoma, Nara, Japan

    T. Miyazaki & C. Ohtsuki

Authors
  1. J. M. Oliveira
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  2. T. Miyazaki
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  3. M. A. Lopes
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  4. C. Ohtsuki
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  5. J. D. Santos
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Correspondence to J. D. Santos.

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Oliveira, J.M., Miyazaki, T., Lopes, M.A. et al. Bonelike®/PLGA hybrid materials for bone regeneration: Preparation route and physicochemical characterisation. J Mater Sci: Mater Med 16, 253–259 (2005). https://doi.org/10.1007/s10856-005-6687-y

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  • DOI: https://doi.org/10.1007/s10856-005-6687-y

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