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Inhibition of peptic activity in the treatment of peptic ulcer

  • Published:
The American Journal of Digestive Diseases

Summary and conclusion

  1. 1.

    Calcium carbonate and aluminum hydroxide preparation, magnesium hydroxide and sodium lauryl sulfate caused decreased peptic activity simultaneously with a rise in the pH.

  2. 2.

    Calcium carbonate, the aluminum hydroxide preparation and magnesium hydroxide caused more marked peptic inhibition than sodium lauryl sulfate.

  3. 3.

    In our studies we were unable to confirm the reported observations that sodium lauryl sulfate inhibits peptic activity in the presence of an unaltered pH.

  4. 4.

    Clinical use of sodium lauryl sulfate on a small number of patients on the usual dietary peptic ulcer management failed to reveal any superiority of this medication over some of the other medications used.

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References

  1. Mann, F. C. and Williamson, C. S. Experimental Production of Peptic Ulcer. Ann. Surg., 77:409, 1923.

    Article  PubMed  CAS  Google Scholar 

  2. Matthews, W. B. and Dragstedt, L. R. Etiology of Gastric and Duodenal Ulcer; Experimental Studies. Surg. Gynec, & Obst, 55:265, 1932.

    Google Scholar 

  3. Palmer, Walter L. Peptic Ulcer and Gastric Secretion. Arch. Surg., 44:452, 1942.

    Google Scholar 

  4. Schiffrin, M. J. and Warren, A. A. Some Factors Concerned in the Production of Experimental Ulceration of the G-I Tract in Cats. Am. J. Digest. Dis., 9:205, 1942.

    CAS  Google Scholar 

  5. Schiffrin, M. J. and Ivy, A. C. Physiology of Gastric Secretion, Particularly as Related to the Ulcer Problem. Arch. Surg., 44:399, 1942.

    Google Scholar 

  6. Buchner, F. Die Pathogenese der Peptischen Veranderungen. Jena, Gustav Fischer, 1931.

    Google Scholar 

  7. Varco, R. L., Code, C. F., Walpole, S. H. and Wangensteen, O. H. Duodenal Ulcer Formation in the Dog by Intramuscular Injections of a Histamine Beeswax Mixture. Am. J. Physiol., 133:475, 1941.

    Google Scholar 

  8. Bucher, G. R. and Ivy, A. C. The Inherent Inadequacies of the Double Histamine Test for Studies on Pepsin Secretion. Am. J. Physiol., 132:654, 1941.

    CAS  Google Scholar 

  9. Shoch, D. and Fogelson, S. J., Quart. Bull. Northwestern Univ. Med. School, 1942, 16:2.

    Google Scholar 

  10. Shoch, D. and Fogelson, S. J. Studies on Peptic Inhibition. Proc. Soc. Exper. Biol. & Med., 50:304, 1942.

    CAS  Google Scholar 

  11. Anson, M. L. and Mirsky, A. E. Estimation of Pepsin with Hemoglobin. J. Gen. Physiol., 16:59, 1932.

    Article  CAS  Google Scholar 

  12. Steigmann, F. and Marks, A. R. Clinical Studies on a New Pepsin Inhibitor. Proc. Soc. Exper. Biol. & Med., 54:25,1943.

    CAS  Google Scholar 

  13. Komarov, S. A. and Komarov, O. The Precipitability of Pepsin by Colloidal Aluminum Hydroxide. Am. J. Digest. Dis., 7:166, 1940.

    CAS  Google Scholar 

  14. Schiffrin, M. J. and Komarov, S. A. The Inactivation of Pepsin by Compounds of Aluminum and Magnesium. Am. J. Digest. Dis., 8:215, 1941.

    CAS  Google Scholar 

  15. Warren, I. A., Front, J. and Kirsner, J. B. The Effect of Antacid Therapy on the Peptic Activity of Gastric Juice in Man. Gastroenterology, 1:102, 1943.

    CAS  Google Scholar 

  16. Kirsner, J. B. and Wolff, R. A. Effect of Sodium Alkyl Sulfate on Peptic Activity of Gastric Contents in Man and in Vitro. Proc. Soc. Exper. Biol. & Med., 54:11, 1943.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of Therapeutics and Internal Medicine and the Gastro-intestinal Clinic of the Cook County Hospital and the Department of Internal Medicine, University of Illinois College of Medicine, Chicago, Illinois

    F. Steigmann & Arthur R. Marks

Authors
  1. F. Steigmann
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  2. Arthur R. Marks
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Aided by a grant from the Nutrition Research Laboratories, Chicago.

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Steigmann, F., Marks, A.R. Inhibition of peptic activity in the treatment of peptic ulcer. Jour. D. D. 11, 173–178 (1944). https://doi.org/10.1007/BF03020248

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  • DOI: https://doi.org/10.1007/BF03020248

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