Auszug
Der Grund warum Distorsionstraumata der Halswirbelsäule (HWS) zu chronischen Schmerzen führen, bleibt bei vielen Patienten ein Rätsel. Besonders verwirrend ist die Tatsache, dass oft keine oder geringe objektive Anhaltspunkte gefunden werden, die das Ausmaß der Beschwerden und Behinderungen erklären können. Ein möglicher Grund der Diskrepanz zwischen Feststellung von peripheren Verletzungen und Beschwerden kann darin liegen, dass die heute zur Verfügung stehenden diagnostischen Mittel ungenügend sind, um periphere Verletzungen auszuschließen. Ein Beispiel dafür ist die Tatsache, dass Facettengelenksverletzungen bei Obduktionen an Unfallopfern nicht mit Computertomographie (CT) festgestellt werden [19].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Andersen OK, Finnerup NB, Spaich EG, Jensen TS, Arendt-Nielsen (2004) Expansion of nociceptive withdrawal reflex receptive fields in spinal cord injured humans. Clin Neurophysiol 115: 2798–2810
Banic B, Petersen-Felix S, Andersen OK, Radanov BP, Villiger PM, Arendt-Nielsen L, Curatolo M (2004) Evidence for spinal cord hypersensitivity in chronic pain after whiplash injury and in fibromyalgia. Pain 107:7–15
Curatolo M, Petersen-Felix S, Arendt-Nielsen L, Giani C, Zbinden AM, Radanov BP (2001) Central hypersensitivity in chronic pain after whiplash injury. Clin J Pain 17:306–315
Dickenson AH, Sullivan AF (1987) Evidence for a role of the nmda receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation. Neuropharmacology 26:1235–1238
Herren-Gerber R, Weiss S, Arendt Nielsen L, Petersen-Felix S, Di Stefano G, Radanov BP, Curatolo M (2004) Modulation of central hypersensitivity by nociceptive input in chronic pain after whiplash injury. Pain Med 5:366–376
Koelbaek Johansen M, Graven-Nielsen T, Schou Olesen A, Arendt-Nielsen L (1999) Generalised muscular hyperalgesia in chronic whiplash syndrome. Pain 83:229–234
Lord SM, Barnsley L, Wallis BJ, McDonald GJ, Bogduk N (1996) Percutaneous radio-frequency neurotomy for chronic cervical zygapophyseal-joint pain. N Engl J Med 335:1721–1726
Luo ZD, Chaplan SR, Higuera ES, Sorkin LS, Stauderman KA, Williams ME, Yaksh TL (2001) Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats. J Neurosci 21:1868–1875
McMahon SB, Wall PD (1984) Receptive fields of rat lamina 1 projection cells move to incorporate a nearby region of injury. Pain 19:235–247
Samad TA, Moore KA, Sapirstein A, Billet S, Allchorne A, Poole S, Bonventre JV, Woolf CJ (2001) Interleukin-1beta-mediated induction of cox-2 in the cns contributes to inflammatory pain hypersensitivity. Nature 410:471–475
Scholz J, Broom DC, Youn DH, Mills CD, Kohno T, Suter MR, Moore KA, Decosterd I, Coggeshall RE, Woolf CJ (2005) Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina ii of the dorsal horn after peripheral nerve injury. J Neurosci 25: 7317–7323
Sheather Reid RB, Cohen ML (1998) Psychophysical evidence for a neuropathic component of chronic neck pain. Pain 75:341–347
Sterling M, Jull G, Vicenzino B, Kenardy J (2003) Sensory hypersensitivity occurs soon after whiplash injury and is associated with poor recovery. Pain 104:509–517
Sterling M, Jull G, Vicenzino B, Kenardy J, Darnell R (2005) Physical and psychological factors predict outcome following whiplash injury. Pain 114:141–148
Suzuki R, Morcuende S, Webber M, Hunt SP, Dickenson AH (2002) Superficial nk1-expressing neurons control spinal excitability through activation of descending pathways. Nat Neurosci 5: 1319–1326
Tiippana EM, Hamunen K, Kontinen VK, Kalso E (2007) Do surgical patients benefit from perioperative gabapentin/pregabalin? A systematic review of efficacy and safety. Anesth Analg 104:1545–1556
Watkins LR, Milligan ED, Maier SF (2001) Spinal cord glia: new players in pain. Pain 93:201–205
Woolf CJ, Salter MW (2000) Neuronal plasticity: increasing the gain in pain. Science 288: 1765–1769
Yoganandan N, Cusick JF, Pintar FA, Rao RD (2001) Whiplash injury determination with conventional spine imaging and cryomicrotomy. Spine 26:2443–2448
Yu XM, Hua M, Mense S (1991) The effects of intracerebroventricular injection of naloxone, phentolamine and methysergide on the transmission of nociceptive signals in rat dorsal horn neurons with convergent cutaneous-deep input. Neuroscience 44:715–723
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Steinkopff Verlag
About this chapter
Cite this chapter
Curatolo, M. (2009). Neurobiologie der Schmerzchronifizierung nach HWS-Distorsionstrauma. In: Graf, M., Grill, C., Wedig, HD. (eds) Beschleunigungsverletzung der Halswirbelsäule. Steinkopff. https://doi.org/10.1007/978-3-7985-1838-4_3
Download citation
DOI: https://doi.org/10.1007/978-3-7985-1838-4_3
Publisher Name: Steinkopff
Print ISBN: 978-3-7985-1837-7
Online ISBN: 978-3-7985-1838-4
eBook Packages: Medicine (German Language)