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Naturally Occurring 2,5-Dioxopiperazines and Related Compounds

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Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

Abstract

Being relatively simple compounds, 2,5-dioxopiperazines are amongst the most ubiquitous peptide derivatives found in nature. Hydrolysates of proteins and polypeptides often contain these anhydro-dimers of amino-acids and they are commonly isolated from cultures of yeast, lichens and fungi. Their existence as a special group of compounds was first recognized around 1900 (1). The great Emil Fischer managed to synthesize many of the simpler members of this family in the early 1900’s (2). The parent compound, 2,5-dioxopiperazine, often referred to as cyclo-gly-gly*, was made in 1888 (3).

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  1. Department of Chemistry, Imperial College of Science and Technology, London, UK

    P. G. Sammes

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    W. Herz

  2. Freiburg i. Br., Germany

    H. Grisebach

  3. Glasgow, UK

    G. W. Kirby

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Sammes, P.G. (1975). Naturally Occurring 2,5-Dioxopiperazines and Related Compounds. In: Zechmeister, L., Herz, W., Grisebach, H., Kirby, G.W. (eds) Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products. Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, vol 32. Springer, Vienna. https://doi.org/10.1007/978-3-7091-7083-0_2

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