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Randomized trial with intracoronary streptokinase versus placebo (The Netherlands)

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Facts and Hopes in Thrombolysis in Acute Myocardial Infarction

Abstract

In 1981 we initiated a randomized trial at the Thoraxcenter in Rotterdam which was later extended to include four other hospitals cooperating in the Netherlands Interuniversity Cardiology Institute: the Zuiderziekenhuis in Rotterdam, the Free University in Amsterdam, the St. Annadal Hospital in Maastricht and the Leiden University Hospital. Since the global results of the study have been published in the Lancet (4) and in other journals (3, 5) we present a summary of the findings and discuss the clinical consequences of the trial.

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References

  1. Kennedy JW, Ritchie JL, Davis KB, Fritz JK (1983) Western Washington randomized trial of intracoronary streptokinase in acute myocardial infarction. N Engl J Med 308:1312–1318

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  2. Laarse A vd, Vermeer F, Hermens WT, Willems GM, Neef K de, Simoons ML, Serruys PW, Res J, Verheugt FWA, Krauss XH, Bär F, Zwaan C de, Lubsen J (1986) Effects of early intracoronary streptokinase on infarct size estimated from cumulative enzyme release and on enzyme release rate. Am Heart J (in press)

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  3. Serruys PW, Simoons ML, Suryapranata H, Vermeer F, Wijns W, Brand M vd, Bär F, Zwaan C de, Krauss XH, Remme WJ, Res J, Verheugt FWA, Domburg R van, Lubsen L, Hugenholtz PG (1986) Preservation of global and regional left ventricular function after early thrombolysis in acute myocardial infarction. JACC 7:717–728

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  4. Simoons ML, Serruys PW, Brand M vd, Bär F, Zwaan C de, Res J, Verheugt FWA, Krauss XH, Remme WJ, Vermeer F, Lubsen J (1985) Improved survival after early thrombolysis in acute myocardial infarction. A randomized trial conducted by the Interuniversity Cardiology Institute in the Netherlands. Lancet II:578–582

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  5. Simoons ML, Serruys PW, Brand M vd, Res J, Verheugt FWA, Krauss XH, Remme WJ, Bär F, Zwaan C de, Laarse A vd, Vermeer F, Lubsen J (1986) Early thrombolysis in acute myocardial infarction: limitation of infarct size and improved survival. JACC 7:729–742

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S. Effert R. von Essen P. G. Hugenholtz R. Uebis M. Verstraete

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© 1986 Springer-Verlag Berlin Heidelberg

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Simoons, M.L. et al. (1986). Randomized trial with intracoronary streptokinase versus placebo (The Netherlands). In: Effert, S., von Essen, R., Hugenholtz, P.G., Uebis, R., Verstraete, M. (eds) Facts and Hopes in Thrombolysis in Acute Myocardial Infarction. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-07174-8_10

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  • DOI: https://doi.org/10.1007/978-3-662-07174-8_10

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-662-07176-2

  • Online ISBN: 978-3-662-07174-8

  • eBook Packages: Springer Book Archive

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