Abstract
Osteoporosis, its clinical sequela manifested by fractures, has become a worldwide health and socioeconomic problem of major proportions. Presently an estimated 75 million people in the United States, Europe, and Japan are afflicted with this disease. The prevalence of osteoporosis has increased in western countries with a growing incidence of vertebral and hip fractures together with a decrease in the age at which they occur. Direct and indirect costs are calculated to be approximately $10 billion per year. Annually, osteoporosis is responsible for at least 1.3 million fractures, 30 000 deaths and long-term domiciliary care in 50% of the survivors in the United States alone.
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Malluche, H.H., Rodgers, J.B. (1994). Animal Models for Osteoporosis. In: Ziegler, R., Pfeilschifter, J., Bräutigam, M. (eds) Sex Steroids and Bone. Ernst Schering Research Foundation Workshop, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03043-1_8
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DOI: https://doi.org/10.1007/978-3-662-03043-1_8
Publisher Name: Springer, Berlin, Heidelberg
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