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View of a Clinician: Sex Steroids and Osteoporosis

  • Conference paper
Sex Steroids and Bone

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 9))

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Abstract

The central role of oestrogen deficiency in the pathogenesis of postmenopausal bone loss and osteoporosis is well established. The association was first recognised by Fuller Albright in 1941 (Albright et al. 1941) and subsequently Aitken et al. (1973a) reported a reduction in metacarpal bone mass in women who had undergone oophorectomy before the age of 45 years, osteopenia developing within 3–6 years after operation. Hormone replacement therapy is the only treatment for osteoporosis in which prevention of bone loss and reduction in fracture rate in the spine, radius and hip has been definitively established. These considerations make it the therapy of choice in the prevention and treatment of osteoporosis in peri- and postmenopausal women but many questions remain unanswered.

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Authors
  1. Juliet E. Compston
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Reinhard Ziegler Johannes Pfeilschifter Matthias Bräutigam

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© 1994 Springer-Verlag Berlin Heidelberg

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Compston, J.E. (1994). View of a Clinician: Sex Steroids and Osteoporosis. In: Ziegler, R., Pfeilschifter, J., Bräutigam, M. (eds) Sex Steroids and Bone. Ernst Schering Research Foundation Workshop, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03043-1_1

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  • DOI: https://doi.org/10.1007/978-3-662-03043-1_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-03045-5

  • Online ISBN: 978-3-662-03043-1

  • eBook Packages: Springer Book Archive

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