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A New Paradigm for Breast Cancer

  • Conference paper
Adjuvant Therapy of Breast Cancer IV

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 127))

Abstract

Adjuvant chemotherapy extends disease-free survival in breast cancer, but it is usually not curative. Naturally, one must ask why. The main reasons often cited for treatment failure are drug resistance and host toxicity. Much research is directed to understanding and combating these effects, which have been known for some years. Although complex strategies for overcoming these obstacles are being developed, the problems have thus far not been resolved. When there is lack of progress, all assumptions need to be questioned, including generally accepted characteristics of tumors. One must examine the current paradigm for breast cancer and consider the experimental and theoretical basis of the paradigm. Most current therapies are based upon the original animal model studies of Skipper and Schabel [31], the kinetic studies of Laird [13], and the theoretical studies of Goldie and Coldman [3]. Our research of the past 10 years has given us reason to seriously doubt the validity of this paradigm [17, 18, 22, 26, 29, 32].

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Author information

Authors and Affiliations

  1. University of Colorado, Colorado Springs, CO, 80933, USA

    M. W. Retsky, D. E. Swartzendruber, P. D. Bame & R. H. Wardwell

Authors
  1. M. W. Retsky
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  2. D. E. Swartzendruber
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  3. P. D. Bame
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  4. R. H. Wardwell
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Editor information

Editors and Affiliations

  1. Department of Medicine C, Kantonsspital, CH-9007, St. Gallen, Switzerland

    Hans-Jörg Senn  & Beat Thürlimann  & 

  2. Division of Biostatistics, Dana Farber Cancer Institute, 44, Binney Street, Boston, MA, 02115, USA

    Richard D. Gelber Ph.D.

  3. Ospedale Civico, CH-6900, Lugano, Switzerland

    Aron Goldhirsch

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© 1993 Springer-Verlag Berlin · Heidelberg

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Retsky, M.W., Swartzendruber, D.E., Bame, P.D., Wardwell, R.H. (1993). A New Paradigm for Breast Cancer. In: Senn, HJ., Gelber, R.D., Goldhirsch, A., Thürlimann, B. (eds) Adjuvant Therapy of Breast Cancer IV. Recent Results in Cancer Research, vol 127. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84745-5_3

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  • DOI: https://doi.org/10.1007/978-3-642-84745-5_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84747-9

  • Online ISBN: 978-3-642-84745-5

  • eBook Packages: Springer Book Archive

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