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How To Combine Adjuvant Chemotherapy and Radiation Therapy

  • Conference paper
Adjuvant Therapy of Breast Cancer IV

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 127))

Abstract

The use of breast-conserving treatment (combining breast-conserving surgery and irradiation, RT) had been well established based on the results of clinical trials demonstrating equivalent survival for patients with early-stage breast cancer treated by this approach or by mastectomy [1–5]. Breast- conserving treatment results in important gains in body image and sexuality for many patients and is now widely used in both the United States and Europe. Over a similar time frame, clinical trials have also demonstrated the effectiveness of adjuvant systemic therapies in prolonging survival [6] (reprinted in part in this volume). Therefore clinicians are now commonly faced with the necessity of combining RT and systemic therapy in patients following conservative surgery. In this chapter we review the available information regarding the integration of RT and chemotherapy (CT) following conservative surgery. We do not address issues related to the combination of RT and tamoxifen or the use of initial CT (discussed elsewhere in this volume).

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Author information

Authors and Affiliations

  1. Departments of Radiation Oncology, Beth Israel Hospital and Dana-Farber Cancer Institute, Boston, MA, USA

    J. R. Harris & A. Recht

  2. Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA, USA

    J. R. Harris & A. Recht

Authors
  1. J. R. Harris
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  2. A. Recht
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Editor information

Editors and Affiliations

  1. Department of Medicine C, Kantonsspital, CH-9007, St. Gallen, Switzerland

    Hans-Jörg Senn  & Beat Thürlimann  & 

  2. Division of Biostatistics, Dana Farber Cancer Institute, 44, Binney Street, Boston, MA, 02115, USA

    Richard D. Gelber Ph.D.

  3. Ospedale Civico, CH-6900, Lugano, Switzerland

    Aron Goldhirsch

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© 1993 Springer-Verlag Berlin · Heidelberg

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Harris, J.R., Recht, A. (1993). How To Combine Adjuvant Chemotherapy and Radiation Therapy. In: Senn, HJ., Gelber, R.D., Goldhirsch, A., Thürlimann, B. (eds) Adjuvant Therapy of Breast Cancer IV. Recent Results in Cancer Research, vol 127. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84745-5_18

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  • DOI: https://doi.org/10.1007/978-3-642-84745-5_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84747-9

  • Online ISBN: 978-3-642-84745-5

  • eBook Packages: Springer Book Archive

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