Skip to main content
SpringerLink
Log in

Growth Kinetics

  • Chapter
Prostate Cancer

  • 77 Accesses

Abstract

The growth rate of a tumour can only be measured if the size can be accurately recorded on two or more occasions. The impracticability of performing such in vivo measurements, of required precision, upon prostate glands has therefore precluded any direct estimates of how fast such tumours grow. A large proportion of cell kinetic studies of the prostate gland have been carried out upon excised tumour specimens or in organ culture. Valuable cell kinetic techniques, such as the percentage of labelled mitoses method for measuring the intermitotic time of proliferating cells, are readily performed in animals (Alison and Wright 1979a), but the necessary repeated sampling over a prolonged interval is not feasible in human subjects, particularly in an ageing population. The lack of any direct estimates of growth rate means that we can only speculate upon the respective roles of cell production and cell loss in determining overall tumour growth rates.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aherne WA, Camplejohn RS, Wright NA (1977) An introduction to cell population kinetics. Edward Arnold, London, pp 11–14

    Google Scholar 

  • Ahmed K, Wilson MJ (1978) Chromatin controls in the prostate. In: Busch H (ed) The cell nucleus, vol 6. Academic Press, New York, pp 409–459

    Google Scholar 

  • Alison MR, Wright NA (1979a) Testosterone-induced cell proliferation in the accessory sex glands of mice at various times after castration. Cell Tissue Kinet 12: 461–475

    PubMed  CAS  Google Scholar 

  • Alison MR, Wright NA (1979b) Testosterone 5α-reductase activity as related to proliferative status in mouse accessory sex glands. J Endocrinol 81: 83–92

    Article  PubMed  CAS  Google Scholar 

  • Alison MR, McHanwell S, Wright NA (1979) Failure of induced functional activity and cell deficit to restore preoperative cell number in paired accessory sex glands following unilateral ablation in castrated male mice. Anat Rec 193: 903–912

    Article  PubMed  CAS  Google Scholar 

  • Baserga R (1976) Multiplication and division in mammalian cells. In: Baserga R (ed) The biochemistry of disease, vol 6. Marcel Dekker, New York, pp 349–360

    Google Scholar 

  • Bichel P, Frederiksen P, Kjaer T, Thommesen P, Vindelov LL (1977) Flow microfluorometry and transrectal fine-needle biopsy in the classification of human prostatic carcinoma. Cancer 40: 1206–1211

    Article  PubMed  CAS  Google Scholar 

  • Brehmer B, Marquardt H, Madsen PO (1972) Growth and hormonal response of cells derived from carcinoma and hyperplasia of the prostate in monolayer cell culture. A possible in vitro model for clinical chemotherapy. J Urol 108: 890–896

    PubMed  CAS  Google Scholar 

  • Byar DP, Mostofi FK (1972) Carcinoma of the prostate: Prognostic evaluation of certain pathologic features in 208 radical prostatectomies. Cancer 30: 5–13

    Article  PubMed  CAS  Google Scholar 

  • Camplejohn RS, Bone G, Aherne W (1973) Cell proliferation in rectal carcinoma and rectal mucosa. A stathmokinetic study. Eur J Cancer 9: 577–581

    PubMed  CAS  Google Scholar 

  • Chawda R, Job L, Horoszewicz JS, Carter WA, Arya SK (1979) Effect of bromodeoxyuridine and interferon on cellular and viral functions in human prostatic cells. Oncology 36: 35–39

    Article  PubMed  CAS  Google Scholar 

  • Cleaver JE (1967) Thymidine metabolism and cell kinetics. In: Neuberger A, Tatum EL (eds) Frontiers of biology, vol 6. North-Holland, Amsterdam

    Google Scholar 

  • Collste L, Darzynkiewicz Z, Traganos F, Sharpless TK, Whitmore WF, Melamed MR (1979) Identification of polymorphonuclear leukocytes in cytological samples for flow cytometry. J Histochem Cytochem 27: 390–393

    Article  PubMed  CAS  Google Scholar 

  • Darzynkiewicz Z, Traganos F, Andreef M, Sharpless T, Melamed MR (1979) Different sensitivity of chromatin to acid denaturation in quiescent and cycling cells as revealed by flow cytometry. J Histochem Cytochem 27: 478–485

    Article  PubMed  CAS  Google Scholar 

  • Dermer GB (1978) Basal cell proliferation in benign prostatic hyperplasia. Cancer 41: 1857–1862

    Article  PubMed  CAS  Google Scholar 

  • Drago JR, Ikeda RM, Maurer RE, Goldman LB, Tesluk H (1979a) The Nb rat: Prostatic adenocarcinoma model. Invest Urol 16: 353–359

    PubMed  CAS  Google Scholar 

  • Drago JR, Maurer RE, Gershwin ME, Eckels D, Palmer JM (1979b) The effect of 5-fluorouracil and adriamycin on heterotransplantation of Noble rat prostatic tumours in congenitally athymic (nude) mice. Cancer 44: 424–430

    Article  PubMed  CAS  Google Scholar 

  • Farber E, Baserga R (1969) Differential effects of hydroxyurea on survival of proliferating cells in vivo. Cancer Res 29: 136–139

    PubMed  CAS  Google Scholar 

  • Farnsworth WE, Montes M (1979) Derivation and determination of a human prostatic epithelial index. Arch Androl 2: 85–88

    Article  PubMed  CAS  Google Scholar 

  • Frederiksen P, Thommesen P, Kjaer TB, Bichel P (1978) Flow cytometric DNA analysis in fine needle aspiration biopsies from patients with prostatic lesions. Diagnostic value and relation to clinical stages. Acta Pathol Microbiol Scand [A] 86: 461–464

    Google Scholar 

  • Fulker MJ, Cooper EH, Tanaka T (1971) Proliferation and ultrastructure of papillary transitional cell carcinoma of the human bladder. Cancer 27: 71–82

    Article  PubMed  CAS  Google Scholar 

  • Hamburger AW, Salmon SE (1977) Primary bioassay of human tumour stem cells. Science 197: 461–463

    Article  PubMed  CAS  Google Scholar 

  • Hamburger AW, Salmon SE, Kim MB, Trent JM, Soehnlen BJ, Alberts DS, Schmidt HJ (1978) Direct cloning of human ovarian carcinoma cells in agar. Cancer Res 38: 3438–3444

    PubMed  CAS  Google Scholar 

  • Helpap B, Stiens R (1975) The cell proliferation of epithelial metaplasia in the prostate gland. Virchows Arch [Cell Pathol] 19: 69–76

    CAS  Google Scholar 

  • Helpap B, Stiens R, Bruhl P (1974) Autoradiographic in vitro investigations on prostatic tissue with the C-14- and H-3-thymidine double-labelling method. Beitr Pathol Anat Allgem Pathol 151:65–74

    CAS  Google Scholar 

  • Hindsley JP, Fried FA, Avis I, Avis FP (1978) Transplantation of human prostate neoplasia into the nude mouse. In: Bonney WW (ed) Workshop on genitourinary cancer immunology. Natl Cancer Inst Monogr 49: 67–69

    Google Scholar 

  • Isaacs JT, Heston WDW, Weissman RM, Coffey DS (1978) Animal models of hormone-sensitive and -insensitive prostatic adenocarcinomas, Dunning R-3327-H, R-3327-HI, and R-3327-AT. Cancer Res 38: 4353–4359

    PubMed  CAS  Google Scholar 

  • King RJB, Mainwaring WIP (1974) Steroid-cell interactions. Butterworths, London, pp 56–85

    Google Scholar 

  • Lasnitzki I, Whitaker RH, Withycombe JFR (1975) The effect of steroid hormones on the growth pattern and RNA synthesis in human benign prostatic hyperplasia in organ culture. Br J Cancer 32: 168–178

    Article  PubMed  CAS  Google Scholar 

  • Liavag I (1968) Mitotic activity of prostatic epithelium. Acta Pathol Microbiol Scand 73: 19–28

    Article  PubMed  CAS  Google Scholar 

  • Mainwaring WIP (1977) The mechanism of action of androgens. Springer, New York (Monographs on endocrinology, vol 10)

    Google Scholar 

  • McMahon MJ, Butler AVJ, Thomas GH (1972) Morphological responses of prostatic carcinoma to testosterone in organ culture. Br J Cancer 26: 388–394

    Article  PubMed  CAS  Google Scholar 

  • McMahon MJ, Thomas GH (1973) Morphological changes of benign prostatic hyperplasia in culture. Br J Cancer 27: 323–335

    Article  PubMed  CAS  Google Scholar 

  • McRae CU, Ghanadian R, Fotherby K, Chisholm GD (1973) The effect of testosterone on the human prostate in organ culture. Br J Urol 45: 156–162

    Article  PubMed  CAS  Google Scholar 

  • Muntzing J, Liljekvist J, Murphy GP (1979) Chalones and stroma as possible growth-limiting factors in the rat ventral prostate. Invest Urol 16: 399–394

    PubMed  CAS  Google Scholar 

  • Pollard M (1973) Spontaneous prostate adenocarcinomas in aged germ-free Wistar rats. J Natl Cancer Inst 51: 1235–1241

    PubMed  CAS  Google Scholar 

  • Rao BR, Nakeff A, Eaton C, Heston WDW (1978) Establishment and characterisation of an in vitro clonogenic cell assay for the R-3327-At Copenhagen rat prostatic tumor. Cancer Res 38: 4431–4439

    PubMed  CAS  Google Scholar 

  • Shain SA, McCullough B, Nitchuk WM (1979) Primary and transplantable adenocarcinomas of the AxC rat ventral prostate gland: Morphologic characterisation and estimation of C19-steroid metabolism by early-passage tumours. J Natl Cancer Inst 62: 313–322

    PubMed  CAS  Google Scholar 

  • Shipman PAM, Littlewood V, Riches AC, Thomas GH (1975) Differences in proliferative activity of rat and human prostate in culture. Br J Cancer 31: 570–580

    Article  PubMed  CAS  Google Scholar 

  • Spooner ME, Cooper EH (1972) Chromosome constitution of transitional-cell carcinoma of the urinary bladder. Cancer 29: 1401–1412

    Article  PubMed  CAS  Google Scholar 

  • Sprenger E, Witte S (1979) The diagnostic significance of nuclear deoxyribonucleic acid measurement in automated cytology. J Histochem Cytochem 27: 520–521

    Article  PubMed  CAS  Google Scholar 

  • Spriggs AI (1976) Chromosomes in human neoplastic diseases. In: Symington T, Carter RL (eds) Scientific foundations of oncology. Heinemann, London, pp 147–155

    Google Scholar 

  • Stiens R, Helpap B, Bruhl P (1975) The proliferation of prostatic epithelium in chronic prostatitis. Urol Res 3: 21–24

    Article  PubMed  CAS  Google Scholar 

  • Steel GG (1977) Growth kinetics of tumours. University Press, Oxford

    Google Scholar 

  • Timms BG, Chandler JA, Sinowatz F (1976) The ultrastructure of basal cells of rat and dog prostate. Cell Tissue Res 173: 543–554

    Article  PubMed  CAS  Google Scholar 

  • Tuohimaa P, Niemi M (1968) The effect of testosterone on cell renewal and mitotic cycles in sex accessory glands of castrated mice. Acta Endocrinol (Kbh) 58: 696–703

    CAS  Google Scholar 

  • Weissman RM, Coffey DS, Scott WW (1977) Cell kinetic studies of prostatic cancer: adjuvant therapy in animal models. Oncology 34: 133–137

    Article  PubMed  CAS  Google Scholar 

  • Wimber DE (1963) Methods for studying cell proliferation with emphasis on DNA labels. In: Lamerton LF, Fry RJM (eds) Cell proliferation. Blackwells, Oxford, pp 1–17

    Google Scholar 

  • Zetterberg A, Esposti PL (1976) Cytophotometric DNA-analysis of aspirated cells from prostatic carcinoma. Acta Cytol 20: 46–57

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, Ducane Road, GB - London, W12 OHS, UK

    M. R. Alison & N. A. Wright

Authors
  1. M. R. Alison
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. A. Wright
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Western General Hospital and Royal Infirmary, Grewe Road, Edinburgh, EH4 2XU, UK

    William Duncan

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Alison, M.R., Wright, N.A. (1981). Growth Kinetics. In: Duncan, W. (eds) Prostate Cancer. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 78. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81621-5_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-81621-5_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81623-9

  • Online ISBN: 978-3-642-81621-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation