Abstract
In the mid-1960s a number of reports were published showing a strong association between reactivity of antibodies in the patient’s pregraft serum with the lymphocytes of the donor (positive crossmatch) and immediate rejection of the renal allograft (hyperacute rejection) (Kissmeyer-Nielsen et al. 1966; Terasaki et al. 1968). This finding meant that performing a crossmatch prior to transplantation was mandatory and a positive crossmatch result was regarded as a strict contraindication to transplantation. At this time it was thought that all lymphocytotoxic antibodies were directed at HLA-A, B, and/or C locus antigens (HLA class I antigens). Since these antigens are found on vascular endothelial cells (Daar et al. 1984), it was reasonable to suppose that they were the cause of the graft failure. Lymphocytotoxic antibodies to antigens other than HLA class I have now been recognized, and their effect on organ grafts is not always deleterious. There is no doubt that an understanding of the various antibody specificities which can be detected in the sera of renal patients is important, particularly if we wish to optimize the chance of transplanting patients with broadly reactive antibodies.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baldwin WM III, Claas FHJ, Paul LC, Springer TA, Hendriks GFJ, van Es LA, van Rood JJ (1983) All monocyte antigens are not expressed on renal endothelium. Tissue Antigens 21:254–259
Berg B, Moller E (1981) Immediate rejection of a HLA-A,B compatible, HLA-DR incompatible kidney with a positive donor-recipient B-cell crossmatch. Scand J Urol Nephrol [Suppl] 54:36
Brasile L, Rodman E, Shield CF, Clarke J, Cerilli J (1986) The association of antivascular endothelial cell antibody with hyperacute rejection: a case report. Surgery 99:637–639
Cerilli J, Bay W, Brasile L (1983) The significance of the monocyte crossmatch in recipients of living-related HLA identical kidney grafts. Hum Immunol 7:45–50
Cochrum KC, Hanes D, Potter D et al (1979) Donor-specific blood transfusions in HLA-D disparate one-haplotype related allografts. Transplant Proc 11:1903–1907
Connors SM, Myrberg S J, Dodds K, Carpenter CB, Garovoy MR (1979) Successful renal allograft in the presence of York (Yka) and autologous B-cell antibodies. Transplant Proc 11:1944–1946
Daar AS, Fuggle SV, Fabre JW, Ting A, Morris PJ (1984) The detailed distribution of HLA-A, B, C antigens in normal human organs. Transplantation 38:287–292
D’Apice AJF, Tait BD (1980) Most positive B cell crossmatches are not caused by anti-HLA-DR antibodies. Transplantation 30:382–383
Esnault V, Bignon JD, Testa A, Preud’Homme JL, Vergracht A, Soulillou JP (1990) Effect of protein A immunoadsorption on panel lymphocyte reactivity in hyperimmunized patients awaiting a kidney graft. Transplantation 50:449–453
Evans PR, Trickett LP, Gosney AR et al (1988) Detection of kidney reactive antibodies at crossmatch in renal transplant recipients. Transplantation 46:844–852
Fuller TC, Cosimi AB, Russell PS (1978) Use of an antiglobulin-ATG reagent for detection of low levels of alloantibody — improvement of allograft survival in presensitized recipients. Transplant Proc 10:463–466
Fuller TC, Phelan D, Gebel HM, Rodey GE (1982) Antigenic specificity of antibody reactive in the antiglobulin-augmented lymphocytotoxicity test. Transplantation 34:24–29
Garovoy MR, Rheinschmidt MA, Bigos M, Perkins H, Colombe B, Feduska N, Salvatierra O (1983) Flow cytometry analysis: a high technology crossmatch technique facilitating transplantation. Transplant Proc 15:1939–1944
Gifford RRM, Doran MM, Ruth JA, Coppage ML, Winsett OE, Fish JC (1986) Positive antiglobulin cytotoxicity crossmatch in renal allograft recipients treated with cyclosporine. Transplantation 42:439–441
Iwaki Y, Cook DJ, Terasaki PI et al (1987) Flow cytometry crossmatching in human cadaver kidney transplantation. Transplant Proc 19:764–766
Jeannet M, Stalder H (1978) Lymphocytotoxic antibodies in spontaneous cytomegalovirus infection. Lancet 1:509
Jeannet M, Bodmer JG, Bodmer WF, Schapira M (1973) Lymphocytotoxic sera associated with the ABO and Lewis red cell blood groups. In: Dausset J, Colombani J (eds) Histocompatibility testing 1972. Munskgaard, Copenhagen, pp 493–499
Jeannet M, Benzonana G, Ami I (1981) Donor-specific B and T lymphocyte antibodies and kidney graft survival. Transplantation 31:160–163
Jordan SC, Yap HK, Sakai RS, Alfonso P, Fitchman M (1988) Hyperacute allograft rejection mediated by anti-vascular endothelial cell antibodies with a negative monocyte crossmatch. Transplantation 46:585–602
Kerman RH, van Buren CT, Lewis RM, DeVera V, Baghdahsarian V, Kahan BD (1990) Improved graft survival for flow cytometry and antihuman globulin crossmatch-negative retransplant recipients. Transplantation 49:52–56
Kissmeyer-Nielsen F, Olsen S, Petersen VP, Fjeldborg O (1966) Hyperacute rejection of kidney allografts associated with pre-existing humoral antibodies against donor cells. Lancet 1:662–665
Lobo PI (1981) Nature of autolymphocytotoxins present in renal hemodialysis patients. Their possible role in controlling alloantibody formation. Transplantation 32:233–237
MacLeod AM, Kurtz J, Chapman JR, Ting A, Morris PJ (1987) Autolymphocytotoxins and virus infection in renal transplantation. Transplant Proc 19:901
Matas A J, Frey DJ, Gillingham KJ et al (1990) The impact of HLA matching of graft survival and on sensitization after a failed transplant — evidence that failure of poorly matched renal transplants does not result in increased sensitization. Transplantation 50:599–607
Mohanakumar T, Rhodes C, Mendez-Picon G, Flye MW, Lee HM (1987) Antiidiotypic antibodies to human major histocompatibility complex class I and II antibodies in hepatic transplantation and their role in allograft survival. Transplantation 44:54–58
Moraes JR, Stastny P (1977) A new antigen system expressed in human enothelial cells. J Clin Invest 60:449–454
Moraes JR, Pettaway C, Stastny P (1989) Prediction of early kidney transplant rejection by a crossmatch with donor skin. Transplantation 48:951–952
Opelz G (1987) Improved kidney graft survival in non-transfused recipients. Transplant Proc 19:149–152
Opelz G, Sengar DPS, Mickey MR, Terasaki PI (1973) Effect of blood transfusions on subsequent kidney transplants. Transplant Proc 5:253–259
Plamer A, Tkube D, Welsh K, Bewick M, Gjorstrup P, Thick M (1989) Removal of anti-HLA antibodies by extracorporeal immunoadsorption to enable renal transplantation. Lancet 1:10–12
Park MS, Oriol R, Nakata S, Terasaki PI, Ford R, Bernoco D (1979) ABH and Lewis antigens on lymphocytes: screening of pregnant women’s sera with the B-cell cytotoxicity test. Transplant Proc 11:1947–1949
Paul LC, Claas FHJ, van Es LA, Kalff MW, de Graeff J (1979) Accelerated rejection of a renal allograft associated with pretransplantation antibodies directed against donor antigens on endothelium and monocytes. N Engl J Med 300:1258–1260
Pellegrino MA, Belvedere M, Pellegrino AG, Ferrone S (1978) B peripheral lymphocytes express more HLA antigens than T peripheral lymphocytes. Transplantation 25:93–95
Phelan D, Oldfather J, Reed E, Suciu-Foca N, Rodey G (1985) Simplified screening procedure for detection of anti-idiotypic antibodies. Transplant Proc 17:2625–2626
Povlsen JV, Graugaard BH, Kissmeyer-Nielsen F (1988) Lymphocytotoxic crossmatching performed on spleen cells: immunomagnetic technique versus current KN (Kissmeyer-Nielsen) technique. Tissue Antigens 33:382–388
Reed E, Hardy M, Lattes C, Brensilver J, McCabe R, Reemtsma K, Suciu-Foca N (1985) Antiidiotypic antibodies and their relevance to transplantation. Transplant Proc 17:735–738
Reed E, Hardy M, Benvenitsky A et al (1987) Effect of antiidiotypic antibodies to HLA on graft survival in renal allograft recipients. N Engl J Med 316:1450–1455
Sanfilippo F, Goeken N, Niblack G, Scornik J, Vaughan WK (1987) The effect of first cadaver renal transplant HLA-A, B match on sensitization levels and retransplant rates following graft failure. Transplantation 43:240–244
Shumak KH, Rachewich RA, Crookston MC, Crookston JH (1971) Antigens of the Ii system on lymphocytes. Nature 231:148–149
Taylor CJ, Chapman JR, Fuggle SV, Ting A, Morris PJ (1987) A positive B cell crossmatch due to IgG and anti-HLA-DQ antibody present at the time of transplantation in a successful renal allograft. Tissue Antigens 30:104–112
Terasaki PI, Thrasher DL, Hauber TH (1968) Serotyping for homotransplantation. XIII. Immediate kidney rejection and associated preformed antibodies. In: Dausset J, Hamburger J, Mathe G (eds) Advance in transplantation. Munksgaard, Copenhagen, pp 225–229
Ting A, Hasegawa T, Ferrone S, Reisfeld RA (1973) Presensitization detected by sensitive crossmatch tests. Transplant Proc 5:813–817
Vartdal F, Gaudernack G, Funderud S, Bratlie A, Lea T, Ugelstad J, Thorsby E (1986) HLA class I and II typing using cells positively selected from blood by immunomagnetic isolation — a fast and reliable method. Tissue Antigens 99:1
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Ting, A. (1993). HLA Antibodies, Non-HLA Antibodies, and Crossmatch Methods. In: Solheim, B.G., Ferrone, S., Möller, E. (eds) The HLA System in Clinical Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77506-2_16
Download citation
DOI: https://doi.org/10.1007/978-3-642-77506-2_16
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-77508-6
Online ISBN: 978-3-642-77506-2
eBook Packages: Springer Book Archive