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Defective Interfering Viruses and Infections of Animals

  • Conference paper
Current Topics in Microbiology and Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 128))

Abstract

Defective interfering (DI) virus particles are generated during the replication of many, possibly all, animal viruses (Huang and Baltimore 1977; Perrault 1981). They characteristically have a genome which contains deletions, often of the majority, of the standard (infectious) virus genome. These deletions mean that DI virus can only replicate in cells co-infected with standard virus. Such co-infection normally results in the enhancement of the DI virus population and a concomitant reduction in standard virus — the phenomenon of interference (Huang and Baltimore 1977; Holland et al. 1980; Perrault 1981). These and other properties of DI viruses are summarised in Table 1. The point that DI virus nucleic acid is encapsidated in the normal complement of coat proteins synthesized by standard virus should be emphasized, since it follows that DI and standard virus are antigenically identical and that they should stimulate and respond to host immune responses in the same way. The intimate biochemical dependence of DI virus on standard virus for its replication as well as encapsidation explains why, for the most part, interference is specific for the homologous standard virus. For an account of the biochemical properties of DI viruses the reader is referred to reviews by Huang and Baltimore (1977), Holland et al. (1980) and Perrault (1981).

The authors thank the Science and Engineering Research Council, Medical Research Council, Agricultural Research Council, The Wellcome Trust and the University of Warwick Research and Innovations Fund for financially supporting their work cited in this review

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References

  • Ada GL, Leung KN, Ertl H (1981) An analysis of effector T cell generation and function in mice exposed to influenza A or Sendai viruses. Immunol Rev 58:5–24

    Article  PubMed  CAS  Google Scholar 

  • Allison AC, Warwick RTT (1949) Quantitative observations on the olfactory system of the rabbit. Brain 72:186–197

    Article  PubMed  CAS  Google Scholar 

  • Atkins GS, Sheahan BJ, Dimmock NJ (1985) Semliki Forest virus infection of mice: a model for genetic and molecular analysis of viral pathogenicity. J Gen Virol 66:395–408

    Article  PubMed  Google Scholar 

  • Atkinson T, Barrett ADT, MacKenzie A, Dimmock NJ (1986) Persistence of virulent Semliki Forest virus in mouse brain following co-inoculation with defective interfering particles. J Gen Virol 67:1189–1194

    Article  PubMed  Google Scholar 

  • Barrett ADT, Dimmock NJ (1984a) Variation in homotypic and heterotypic interference by defective interfering viruses derived from different strains of Semliki Forest virus and from Sindbis virus. J Gen Virol 65:1119–1122

    Article  PubMed  Google Scholar 

  • Barrett ADT, Dimmock NJ (1984 b) Modulation of Semliki Forest virus-induced infection of mice by defective interfering virus. J Infect Dis 150:98–104

    Article  PubMed  CAS  Google Scholar 

  • Barrett ADT, Dimmock NJ (1984c) Properties of host and virus which influence defective interfering virus-mediated protection of mice against Semliki Forest virus lethal encephalitis. Arch Virol 81:185–188

    Article  PubMed  CAS  Google Scholar 

  • Barrett ADT, Dimmock NJ (1984d) Modulation of a systemic Semliki Forest virus infection in mice by defective interfering virus. J Gen Virol 65:1827–1831

    Article  PubMed  Google Scholar 

  • Barrett ADT, Crouch CF, Dimmock NJ (1981) Assay of defective-interfering Semliki Forest virus by the inhibition of synthesis of virus-specified RNAs. J Gen Virol 54:273–280

    Article  PubMed  CAS  Google Scholar 

  • Barrett ADT, Crouch CF, Dimmock NJ (1984a) Defective interfering Semliki Forest virus populations are biologically and physically heterogeneous. J Gen Virol 65:1273–1283

    Article  PubMed  CAS  Google Scholar 

  • Barrett ADT, Guest AR, Mackenzie A, Dimmock NJ (1984 b) Protection of mice infected with a lethal dose of Semliki Forest virus by defective interfering virus: modulation of virus multiplication. J Gen Virol 65:1909–1920

    Article  PubMed  Google Scholar 

  • Barrett ADT, Cross AJ, Crow TJ, Johnson JA, Guest AR, Dimmock NJ (1986) Subclinical infections in mice resulting from the modulation of a lethal dose of Semliki Forest virus with defective interfering viruses: neurochemical abnormalities in the central nervous system. J Gen Virol 67: in press

    Google Scholar 

  • Baumann RP, Dauenhauer SA, Caughman GB, Staczek J, O’Callaghan DJ (1984) Structure and genetic complexity of the genomes of herpesvirus defective-interfering particles associated with oncogenic transformation and persistent infection. J Virol 50:13–21

    PubMed  CAS  Google Scholar 

  • Bean WJ, Kawaoka Y, Wood JM, Pearson JE, Webster RG (1985) Characterization of virulent and avirulent A/chicken/Pennsylvania/83 influenza A viruses: potential role of defective interfering RNAs in nature. J Virol 54:151–160

    PubMed  CAS  Google Scholar 

  • Bernkopf H (1950) Study of infectivity and haemagglutination of influenza virus in deembryonated eggs. J Immunol 65:571–583

    PubMed  CAS  Google Scholar 

  • Biron CA, Habu S, Okumura K, Welsh RM (1984) Lysis of uninfected and virus-infected cells in vivo: a rejection mechanism in addition to that mediated by natural killer cells. J Virol 50:698–707

    PubMed  CAS  Google Scholar 

  • Bose HR Jr (1984) Reticuloendotheliosis virus and disturbance in immune regulation. Microbiol Sci 1:107–112

    PubMed  Google Scholar 

  • Brinton MA (1983) Analysis of extracellular West Nile virus particles produced by cell cultures from genetically resistant and susceptible mice indicates enhanced amplification of defective interfering particles by resistant cultures. J Virol 46:860–870

    PubMed  CAS  Google Scholar 

  • Buchmeier MJ, Welsh RM, Dutko FJ, Oldstone MBA (1980) The virology and immunobiology of lymphocytic choriomeningitis virus infection. Adv Immunol 30:275–331

    Article  PubMed  CAS  Google Scholar 

  • Campbell DE, Kemp MC, Perdue ML, Randall CC, Gentry GA (1976) Equine herpesvirus in vivo: cyclic production of a DNA density variant with repetitive sequences. Virology 69:737–750

    Article  PubMed  CAS  Google Scholar 

  • Carter BJ, Laughlin CA, de la Maza LM, Myers M (1979) Adeno-associated virus autointerference. Virology 92:449–462

    Article  PubMed  CAS  Google Scholar 

  • Carter MJ, Willcocks MM, ter Meulen V (1983) Defective translation of measles virus matrix protein in a subacute sclerosing panencephalitis cell line. Nature 305:153–155

    Article  PubMed  CAS  Google Scholar 

  • Cave DR, Hagen FS, Palma EL, Huang AS (1984) Detection of vesicular stomatitis virus RNA and its defective-interfering particles in individual mouse brains. J Virol 50:86–91

    PubMed  CAS  Google Scholar 

  • Cave DR, Hendricksen FM, Huang AS (1985) Defective interfering particles modulate virulence. J Virol 55:366–373

    PubMed  CAS  Google Scholar 

  • Cernescu C, Sorodoc Y (1980) Subacute sclerosing panencephalitis and defective interfering measles virus particles. Rev Roum Med Virol 31:3–8

    CAS  Google Scholar 

  • Crick J, Brown F (1977) In vivo interference in vesicular stomatitis virus infection. Infect Immun 15:354-359

    PubMed  CAS  Google Scholar 

  • Crouch CF, Mackenzie A, Dimmock NJ (1982) The effect of defective interfering Semliki Forest virus on the histopathology of infection with virulent Semliki Forest virus in mice. J Infect Dis 146:411–416

    Article  PubMed  CAS  Google Scholar 

  • Darnell MB, Koprowski H (1974) Genetically determined resistance to infection with group B arboviruses. II. Increased production of interfering particles in cell cultures from resistant mice. J Infect Dis 129:248–256

    Article  PubMed  CAS  Google Scholar 

  • de la Maza LM, Carter BJ (1981) Inhibition of adenovirus tumorigenicity by adenoassociated virus. J Natl Cancer Inst 67:1323–1326

    PubMed  Google Scholar 

  • Dimmock NJ, Kennedy SIT (1978) Prevention of death in Semliki Forest virus-infected mice by administration of defective-interfering Semliki Forest virus. J Gen Virol 39:231–242

    Article  PubMed  CAS  Google Scholar 

  • Dimmock NJ, Beck S, McLain L (1986) Protection of mice from lethal influenza by DI virus: unsuspected mechanisms. J Gen Virol 67:839–850

    Article  PubMed  CAS  Google Scholar 

  • Dobos P, Roberts TE (1983) The molecular biology of infectious pancreatic necrosis virus: a review. Can J Microbiol 29:377–384

    Article  PubMed  CAS  Google Scholar 

  • Doyle M, Holland JJ (1973) Prophylaxis and immunisation in mice by use of virus-free defective T particles to protect against intracerebral infection by vesicular stomatitis virus. Proc Natl Acad Sci USA 70:2105–2108

    Article  PubMed  CAS  Google Scholar 

  • Eckner RJ, Hettrick KL (1977) Defective spleen focus-forming virus: interfering properties and isolation free from standard leukaemia-inducing helper virus. J Virol 24:383–396

    PubMed  CAS  Google Scholar 

  • Eckner RJ, Hettrick KL (1979) Persistence and pathogenicity of defective Friend spleen focus-forming virus. J Exp Med 149:340–357

    Article  PubMed  CAS  Google Scholar 

  • Faulkner G, Dubois-Dalcq M, Hooghe-Peters E, McFarland HF, Lazzarini RA (1979) Defective interfering particles modulate VSV infection of dissociated neuron cultures. Cell 17:979–991

    Article  PubMed  CAS  Google Scholar 

  • Fazekas de St Groth S, Graham D (1954) The production of incomplete virus particles among influenza virus strains: experiments in eggs. Br J Exp Pathol 35:60–74

    PubMed  CAS  Google Scholar 

  • Fields S, Winter G (1982) Nucleotide sequence of influenza virus segments 1 and 3 reveal mosaic structure of a small viral RNA segment. Cell 28:303–313

    Article  PubMed  CAS  Google Scholar 

  • Fleckenstein B, Bornkamm GS, Ludwig H (1975) Repetitive sequences in complete and defective genomes of Herpesvirus saimiri. J Virol 15:398–406

    PubMed  CAS  Google Scholar 

  • Frenkel N (1981) Defective interfering herpesviruses. In: Nahmias AJ, Dowdle WR, Schinazi RF (eds) The human herpes viruses. Elsevier/North-Holland, New York, pp 91–120

    Google Scholar 

  • Fultz PN, Shadduck JA, Kang C-Y, Streilein JW (1981) On the mechanism of DI particle protection against lethal VSV infection in hamsters. In: Bishop DHL, Compans RW (eds) Replication of negative strand viruses. Elsevier/North-Holland, New York, pp 893–899

    Google Scholar 

  • Fultz PN, Shadduck JA, Kang C-Y, Streilein JW (1982a) Mediators of protection against lethal systemic vesicular stomatitis virus infection in hamsters. Defective interfering particles, polyinosinate-polycytidylate and interferon. Infect Immun 37:679–686

    PubMed  CAS  Google Scholar 

  • Fultz PN, Shadduck JA, Kang C-Y, Streilein JW (1982b) Vesicular stomatitis virus can establish persistent infection in Syrian hamsters. J Gen Virol 63:493–497

    Article  PubMed  CAS  Google Scholar 

  • Fultz PN, Holland JJ, Knobler R, Oldstone MBA (1984) Long term persistence by vesicular stomatitis virus in hamsters. In: Compans RW, Bishop DHL (eds) Nonsegmented negative strand viruses. Academic, New York, pp 489–496

    Google Scholar 

  • Gamboa ET, Harter DH, Duffy PE, Hsu KC (1976) Murine influenza virus encephalomyelitis. III. Effect of defective interfering virus particles. Acta Neuropathol (Berl) 34:157–169

    Article  CAS  Google Scholar 

  • Hall WW, Martin SJ, Gould E (1974) Defective interfering particles produced during the replication of measles virus. Med Microbiol Immunol 160:155–164

    Article  PubMed  CAS  Google Scholar 

  • Help GI, Coto CE (1980) Genesis de particulas interferentes durante la multiplication del virus Junin in vivo. Medicina (B Aires) 40:531–536

    CAS  Google Scholar 

  • Hoelzer JD, Lewis RB, Wasmuth CF, Bose HR Jr (1980) Hematopoietic cell transformation by reticuloendotheliosis virus: characterization of the genetic defect. Virology 100:462–474

    Article  PubMed  CAS  Google Scholar 

  • Holland JJ, Doyle M (1973) Attempts to detect homologous autointerference in vivo with influenza virus and vesicular stomatitis virus. Infect Immun 7:526–531

    PubMed  CAS  Google Scholar 

  • Holland JJ, Villarreal LP (1975) Purification of defective interfering T particles of vesicular stomatitis and rabies viruses generated in vivo in brains of newborn mice. Virology 67:438–449

    Article  PubMed  CAS  Google Scholar 

  • Holland JJ, Villarreal LP, Breindl M (1976a) Factors involved in the generation and replication of rhabdovirus defective T particles. J Virol 17:805–815

    PubMed  CAS  Google Scholar 

  • Holland JJ, Villarreal LP, Breindl M, Semler BL, Kohne D (1976b) Defective interfering virus particles attenuate virus lethality in vivo and in vitro. In: Baltimore D, Huang AS, Fox CF (eds) Animal virology. Academic, New York, pp 773–786

    Google Scholar 

  • Holland JJ, Semler BL, Jones C, Perrault J, Reid L, Roux L (1978) Role of DI virus, mutation and host response in persistent infections by enveloped RNA viruses. In: Stevens JG, Todaro GJ, Fox CF (eds) Persistent viruses. Academic, New York, pp 57–73

    Google Scholar 

  • Holland JJ, Kennedy SIT, Semler BL, Jones CL, Roux L, Grabau E (1980) Defective interfering RNA viruses and the host cell response. In: Fraenkel-Conrat H, Wagner RR (eds) Comprehensive virology, vol 16. Plenum, New York, pp 137–192

    Chapter  Google Scholar 

  • Horodyski FM, Holland JJ (1984) Reconstruction experiments demonstrating selective effects of defective interfering particles on mixed populations of vesicular stomatitis virus. J Gen Virol 65:819–813

    Article  PubMed  Google Scholar 

  • Horodyski FM, Nichol ST, Spindler KR, Holland JJ (1983) Properties of DI particle-resistant mutants of vesicular stomatitis virus isolated from persistent infections and from undiluted passages. Cell 33:801–810

    Article  PubMed  CAS  Google Scholar 

  • Huang AS (1977) Viral pathogenesis and molecular biology. Bacteriol Rev 41:811–821

    PubMed  CAS  Google Scholar 

  • Huang AS, Baltimore D (1970) Defective viral particles and viral disease processes. Nature 226:325–327

    Article  PubMed  CAS  Google Scholar 

  • Huang AS, Baltimore D (1977) Defective interfering animal viruses. In: Fraenkel-Conrat H, Wagner RR (eds) Comprehensive virology, vol 10. Plenum, New York, pp 73–116

    Google Scholar 

  • Huang AS, Little SP, Oldstone MBA, Rao D (1978) Defective interfering particles: their effect on gene expression and replication of vesicular stomatitis virus. In: Stevens JG, Todaro GJ, Fox CF (eds) Persistent viruses. Academic, New York, pp 399–408

    Google Scholar 

  • Hurd J, Heath RB (1975) Effect of cyclophosphamide on infections in mice caused by virulent and avirulent strains of influenza virus. Infect Immun 11:886–889

    PubMed  CAS  Google Scholar 

  • Jacobson S, Pfau CJ (1980) Viral pathogenesis and resistance to defective interfering particles. Nature 283:311–313

    Article  PubMed  CAS  Google Scholar 

  • Jennings PA, Finch JT, Winter G, Robertson JS (1983) Does the higher order structure of the influenza virus ribonucleoprotein guide sequence rearrangements in influenza virus RNA? Cell 34:619–627

    Article  PubMed  CAS  Google Scholar 

  • Jones CL, Holland JJ (1980) Requirements for DI particle prophylaxis in vesicular stomatitis virus infection in vivo. J Gen Virol 49:215–220

    Article  PubMed  CAS  Google Scholar 

  • Kääriäinen L, Pettersson RF, Keränen S, Lehtovaara P, Söderlund H, Ukkonen P (1981) Multiple structurally related defective interfering RNAs formed during undiluted passages of Semliki Forest virus. Virology 113:686–697

    Article  PubMed  Google Scholar 

  • Kawai A, Matsumoto S (1982) A sensitive bioassay system for detecting defective interfering particles of rabies virus. Virology 122:98–108

    Article  PubMed  CAS  Google Scholar 

  • Kirchstein RL, Smith KO, Peters EA (1968) Inhibition of adenovirus 12 oncogenicity by adeno-associated virus. Proc Soc Exp Biol Med 128:670–673

    Google Scholar 

  • Koprowski H (1954) Biological modification of rabies virus as a result of its adaptation to chicks and developing chick embryos. Bull WHO 10:709–724

    PubMed  CAS  Google Scholar 

  • Lehtovaara P, Söderlund H, Keränen S, Pettersson RF, Kääriäinen L (1981) 18S defective interfering RNA of Semliki Forest virus contains a triplicated linear repeat. Proc Natl Acad Sci USA 78:5353–5357

    Article  PubMed  CAS  Google Scholar 

  • Lehtovaara P, Söderlund H, Keränen S, Pettersson RF, Kääriäinen L (1982) Extreme ends of the genome are conserved and rearranged in the defective interfering RNAs of Semliki Forest virus. J Mol Biol 156:731–748

    Article  PubMed  CAS  Google Scholar 

  • Leung KN, Ada GL (1980) Cells mediating delayed-type hypersensitivity in the lungs of mice infected with an influenza A virus. Scand J Immunol 12:393–400

    Article  PubMed  CAS  Google Scholar 

  • Liew FY, Russell SM (1983) Inhibition of pathogenic effect of effector T cells by specific suppressor T cells during influenza virus infection in mice. Nature 304:541–543

    Article  PubMed  CAS  Google Scholar 

  • MacDonald RD, Yamamoto T (1978) Quantitative analysis of defective interfering particles in infectious pancreatic necrosis virus preparations. Arch Virol 57:77–89

    Article  PubMed  CAS  Google Scholar 

  • Mayor HD, Houlditch GS, Mumford DM (1973) Influence of adenoassociated satellite virus on adenovirus-induced tumors in hamsters. Nature New Biol 241:44–46

    Article  PubMed  CAS  Google Scholar 

  • Meier-Ewert H, Dimmock NJ (1970) The role of the neuraminidase of the infecting virus in the production of noninfectious (von Magnus) influenza virus. Virology 42:794–798

    Article  PubMed  CAS  Google Scholar 

  • Mims CA (1956) Rift Valley fever virus in mice. IV. Incomplete virus: its production and properties. Br J Exp Pathol 37:129–143

    PubMed  CAS  Google Scholar 

  • Mims CA (1964) Aspects of the pathogenesis of virus diseases. Bact Rev 28:30–71

    PubMed  CAS  Google Scholar 

  • Monroe SS, Schlesinger S (1984) Common and distinct regions of defective interfering RNAs of Sindbis virus. J Virol 49:865–872

    PubMed  CAS  Google Scholar 

  • Monroe SS, Ou J-H, Rice CM, Schlesinger S, Strauss EG, Strauss JH (1982) Sequence analysis of cDNAs derived from the RNA of Sindbis virions and of defective interfering particles. J Virol 41:153–162

    PubMed  CAS  Google Scholar 

  • Nayak DP, Sivasubramanian N (1983) The structure of influenza virus defective interfering (DI) RNAs and their progenitor genes. In: Palese P, Kingsbury DW (eds) Genetics of influenza viruses. Springer, Vienna New York, pp 255–279

    Google Scholar 

  • Nayak DP, Chambers TM, Akkina RK (1985) Defective-interfering (DI) RNAs of influenza viruses: origin, structure, expression and interference. Curr Top Microbiol Immunol 114:103–151

    Article  PubMed  CAS  Google Scholar 

  • Nichol ST, O’Hara PJ, Holland JJ, Perrault J (1984) Structure and origin of a novel class of defective interfering particles of vesicular stomatitis virus. Nucleic Acids Res 12:2775–2790

    Article  PubMed  CAS  Google Scholar 

  • O’Hara PJ, Nichol ST, Horodyski FM, Holland JJ (1984) Vesicular stomatitis virus defective interfering particles can contain extensive genome sequence rearrangements and base substitutions. Cell 36:915–924

    Article  PubMed  Google Scholar 

  • Pedley S, Hundley F, Chrystie I, McCrae MA, Desselberger U (1984) The genomes of rotaviruses isolated from chronically infected immunodeficient children. J Gen Virol 65:1141–1150

    Article  PubMed  CAS  Google Scholar 

  • Perrault J (1981) Origin and replication of defective interfering particles. Curr Top Microbiol Immunol 93:151–207

    Article  PubMed  CAS  Google Scholar 

  • Popescu M, Lehmann-Grube F (1977) Defective interfering particles in mice infected with lymphocytic choriomeningitis virus. Virology 77:78–83

    Article  PubMed  CAS  Google Scholar 

  • Popescu M, Schaefer H, Lehmann-Grube F (1976) Homologous interference of lymphocytic choriomeningitis virus: detection and measurement of interference focus-forming units. J Virol 20:1–8

    PubMed  CAS  Google Scholar 

  • Rabinowitz SG, Huprikar J (1979) The influence of defective interfering particles of the PR-8 strain of influenza A virus on the pathogenesis of pulmonary infection of mice. J Infect Dis 140:305–315

    Article  PubMed  CAS  Google Scholar 

  • Rabinowitz SG, Dal Canto MC, Johnson TC (1977) Infection of the central nervous system produced by mixtures of defective-interfering particles and wildtype vesicular stomatitis virus in mice. J Infect Dis 136:59–74

    Article  PubMed  CAS  Google Scholar 

  • Rawls WE, Chan MA, Gee SR (1981) Mechanisms of persistence in arenavirus infections: a brief review. Can J Microbiol 27:568–574

    Article  PubMed  CAS  Google Scholar 

  • Robinson WS (1978) Persistent infection with hepatitis B virus. In: Stevens JG, Todaro GJ, Fox CF (eds) Persistent viruses. Academic, New York, pp 485–497

    Google Scholar 

  • Roux L, Waldvogel FA (1983) Defective interfering particles of Sendai virus modulate HN expression on the surface of infected BHK cells. Virology 130:91–104

    Article  PubMed  CAS  Google Scholar 

  • Roux L, Beffy P, Portner A (1984) Restriction of cell surface expression of Sendai virus HN glycoprotein correlates with its high instability in persistently and standard plus DI virus infected BHK-21 cells. Virology: 118–128

    Google Scholar 

  • Roux L, Beffy P, Portner A (1985) Three variations in the cell surface expression of the haemagglutinin — neuraminidase glycoprotein of Sendai virus. J Gen Virol 66:987–1000

    Article  PubMed  CAS  Google Scholar 

  • Ruiz-Opazo N, Chakraborty PR, Shafritz DA (1982) Evidence for supercoiled hepatitis B virus DNA in chimpanzee liver and serum dane particles: possible implications in persistent HBV infection. Cell 29:129–138

    Article  PubMed  CAS  Google Scholar 

  • Rup BJ, Spence JL, Hoelzer JD, Lewis RB, Carpenter CR, Rubin AS, Bose HR Jr (1979) Immunosuppression induced by avian reticuloendotheliosis virus: mechanism of induction of the suppressor cell. J Immunol 123:1361–1370

    Google Scholar 

  • Smith AL (1981) Genetic resistance to lethal flavivirus encephalitis: effects of host use and immune status and route of inoculation and production of interfering Banzi virus in vivo. Am J Trop Med Hyg 30:1319–1323

    PubMed  CAS  Google Scholar 

  • Southern PJ, Blount P, Oldstone MBA (1984) Analysis of persistent virus infections by in situ hybridization to whole-mouse sections. Nature 312:555–558

    Article  PubMed  CAS  Google Scholar 

  • Spandidos DA, Graham AF (1976) Generation of defective virus after infection of newborn rats with reovirus. J Virol 20:234–237

    PubMed  CAS  Google Scholar 

  • Stark C, Kennedy SIT (1978) The generation and propagation of defective-interfering particles of Semliki Forest virus in different cell types. Virology 89:285–299

    Article  PubMed  CAS  Google Scholar 

  • Sullivan JL, Mayner RE, Barry DW, Ennis FA (1976) Influenza virus infection in nude mice. J Infect Dis 133:91–94

    Article  PubMed  CAS  Google Scholar 

  • Suzuki F, Ohya J, Ishida N (1974) Effect of anti-lymphocyte serum on influenza infection. Proc Soc Exp Biol Med 146:78–84

    PubMed  CAS  Google Scholar 

  • Toolan HW, Ledinko N (1968) Inhibition by H-1 virus of the incidence of tumors produced by adenovirus type 12 in hamsters. Virology 35:475–478

    Article  PubMed  CAS  Google Scholar 

  • von Magnus P (1951) Propagation of the PR8 strain of influenza A virus in chick embryos. III. Properties of the incomplete virus produced in several passages of undiluted virus. Acta Pathol Microbiol Scand 29:157–181

    Article  Google Scholar 

  • Walker MH, Rup BH, Rubin AS, Bose HR Jr (1983) Specificity in the immunosuppression induced by avian reticuloendotheliosis virus. Infect Immun 40:225–235

    PubMed  CAS  Google Scholar 

  • Welsh RM, Oldstone MBA (1977) Inhibition of immunologic injury of cultured cells infected with lymphocytic choriomeningitis virus: role of defective interfering virus in regulating viral antigenic expression. J Exp Med 145:1449–1468

    Article  PubMed  CAS  Google Scholar 

  • Welsh RM, Lampert PW, Oldstone MBA (1977) Prevention of virus-induced cerebellar disease by defective interfering lymphocytic choriomeningitis virus. J Infect Dis 136:391–399

    Article  PubMed  CAS  Google Scholar 

  • Wiktor TJ, Dietzschold B, Leamnson RN, Koprowski H (1977) Induction and biological properties of defective interfering particles of rabies virus. J Virol 21:626–635

    PubMed  CAS  Google Scholar 

  • Winship TR, Thacore HR (1980) A sensitive method for quantification of vesicular stomatitis virus defective interfering particles: focus-forming assay. J Gen Virol 48:237–240

    Article  PubMed  CAS  Google Scholar 

  • Wunner WH, Clark HF (1980) Regeneration of DI particles of virulent and attenuated rabies virus: genome characterization and lack of correlation with virulence phenotype. J Gen Virol 51:69–81

    Article  PubMed  CAS  Google Scholar 

  • Wyde PR, Couch RB, Mackler T, Cate TR, Levy BM (1977) Effects of low- and high-passage influenza in normal and nude mice. Infect Immun 15:221–229

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Microbiology, University of Surrey, GU2 5XH, Guildford, Surrey, UK

    A. D. T. Barrett

  2. Department of Biological Sciences, University of Warwick, CV4 7AL, Coventry, UK

    N. J. Dimmock

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  1. A. D. T. Barrett
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Editors and Affiliations

  1. Victoria, Parkville, USA

    A. Clarke

  2. Alabama, Birmingham, UK

    R. W. Compans

  3. Alabama, Birmingham, UK

    M. Cooper

  4. Paris, France

    H. Eisen

  5. Würzburg, Germany

    W. Goebel

  6. Philadelphia, USA

    H. Koprowski

  7. Basel, Switzerland

    F. Melchers

  8. La Jolla, California, USA

    M. Oldstone

  9. Gießen, Germany

    R. Rott

  10. Los Angeles, USA

    P. K. Vogt

  11. Ulm, Germany

    H. Wagner

  12. La Jolla, California, USA

    I. Wilson

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Barrett, A.D.T., Dimmock, N.J. (1986). Defective Interfering Viruses and Infections of Animals. In: Clarke, A., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 128. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71272-2_2

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