Zusammenfassung
Fetale kernhaltige Blutzellen sind interessante Zielzellen für eine nichtinvasive pränatale genetische Diagnostik. Einerseits stellen kernhaltige Blutzellen einen großen Teil der fetalen Blutzellen und würden also bei einer fetomaternalen Blutung in ausreichender Zahl in die maternale Zirkulation übertreten. Andererseits könnte der Wachstumsvorteil fetaler Blutzellen eine selektive Anreicherung ermöglichen.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Bohmer RM, Johnson KL, Bianchi DW (2000) Differential effects of interleukin-3 on fetal and adult erythroid cells in culture: implications for the isolation of fetal cells from maternal blood. Prenat Diagn 20(8):640–647
Bohmer RM, Zhen D, Bianchi DW (1998) Differential development of fetal and adult haemoglobin profiles in colony culture: isolation of fetal nucleated red cells by two-colour fluorescence labelling. Br J Haemato 103(2):351–360
Bohmer RM, Zhen D, Bianchi DW (1999) Identification of fetal nucleated red cells in co-cultures from fetal and adult peripheral blood: differential effects of serum on fetal and adult erythropoiesis. Prenat Diagn 19(7):628–636
Broxmeyer HE, Douglas GW, Hangoc G, Cooper S, Bard J, English D et al (1989) Human umbilical cord blood as potential source of transplantable irihematopoietic stem/progenitor cells. Proc Natl Acad Sci USA 86:3828–3832
Chen H, Griffin DK, Jestice K, Hackett G, Cooper J, Ferguson-Smith MA (1998) Evaluating the culture of fetal erythroblasts form maternal blood for non-invasive prenatal diagnosis. Prenat Diagn 18(9):883–892
Coulombel L, Vuillet MH, Leroy C, Tchernia G (1988) Lineage-and stage-specific adhesion of human hematopoietic progenitor cells to extracellular matrices from marrow fibroblasts. Blood 71(2): 329–334
Donnenfeld AE, Scott SC, Henselder-Kimmel M, Dampier CD (1994) Prenatally diagnosed non-immune hydrops caused by congenital transient leukaemia. Prenat Diagn 14(8):721–724
Forestier F, Daffos F, Catherine N, Renard M, Andreuy JP (1991) Developmental hematopoiesis in normal human blood. Blood 77:2360–2363
Hassan MW, Lutton JD, Levere RD, Rieder RF, Cederqvist LL (1979) In vitro culture of erythroid colonies from human fetal liver and umbilical cord blood. Br J Haematol 41(4):477–484
Huber K, Bittner J, Worofka B, Rosen A, Hafner E, Philipp K, Bauer K (2000) Quantitative FISH analysis and in vitro suspension cultures of erythroid cells from maternal peripheral blood for the isolation of fetal cells. Prenat Diagn 20(6):479–486
Kögler G, Callejas J, Hakenberg P, Anczmann J, Adams O, Daubener W et al (1996) Hematopoietic transplant potential of unrelated cord blood: critical issues. J Hematother 5:105–116
Linch DC, Knott LJ, Rodeck CH, Huehns ER (1982) Studies of circulating hemopoietic progenitor cells in human fetal blood. Blood 59(5):976–979
Lo YM, Morey AL, Wainscoat JS, Fleming KA (1994) Culture of fetal erythroid cells from maternal peripheral blood. Lancet 344(8917):264–265
Luo HY, Liang XL, Frye C, Wonio M, Hankins GDV, Chui DHK, Alter BP (1999) Embryonic hemoglobins are expressed in definitive cells. Blood 94(1):359–361
Macones GA, Johnson A, Tilley D, Wade R, Wapner R (1995) Fetal hepatosplenomegaly associated with transient myeloproliferative disorder in trisomy 21. Fetal Diagn Ther 10(2):131–133
Migliaccio G, Biaocchi M, Hamel N, Eddleman K, Migliaccio AR (1996) Circulationg progenitor cells in human ontogenesis: response to growth factors and replanting potential. J Hematother 5:161–170
Péault B (1996) Hematopoietic stem cell emergence in embryonic life: developmental hematology revisited. J Hematother 5:369–378
Sakatoku H, Inoue S (1997) In Vitro Proliferation and Differentiation of Erythroid Progenitors of Cord Blood. Stem Cells 15:268–274
Slunga-Tallberg A, el-Rifai W, Keinanen M, Ylinen K, Kurki T, Klinger K, Ylikorkala O, Knuutila S (1995) Maternal origin of nucleated erythrocytes in peripheral venous blood of pregnant women. Hum Genet 96(1):53–57
Tavassoli M (1991) Embryonic and fetal hemopoiesis: an overview. Blood Cells 17(2):269–281
Thilaganathan B, Stagiannis K, Meher-Homji NJ, Plachouras N, Nicolaides KH (1994) Fetal blood mononuclear cell division in normal and pathological pregnancies. Fetal Diagn Ther 9(2):79–83
Tutschek B, Reinhard J, Kogler G, Wernet P, Niederacher D (2000) Clonal culture of fetal cells from maternal blood. Lancet 356(9243):1736–1737
Valerio D, Aiello R, Altieri V, Malato AP, Fortunato A, Canazio A (1996) Culture of fetal erythroid progenitor cells from maternal blood for non-invasive prenatal genetic diagnosis. Prenat Diagn 16(12):1073–1082
Valerio D, Aiello R, Altieri V (1997) Isolation of fetal erythroid cells from maternal blood based on expression of erythropoietin receptors. Mol Hum Reprod 3(5):451–455
Valerio D, Altieri V, Cavallo D, Aiello R, Antonucci FR (2000) Detection of fetal trisomy 18 by short-term culture of maternal peripheral blood. Am J Obstet Gynecol 183(1):222–225
Weinberg RS, Thomson JC, Lao R, Chen G, Alter BP (1993) Stem cell factor amplifies newborn and sickle erythropoiesis in liquid cultures. Blood 81:2591–2599
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Tutschek, B., Reinhard, J. (2002). Anzüchtung fetaler Blutzellen aus dem mütterlichen Blut. In: Beckmann, M.W., Fasching, P.A., Dall, P., Krüssel, JS., Niederacher, D., Tutschek, B. (eds) Molekulare Medizin in der Frauenheilkunde. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57533-4_7
Download citation
DOI: https://doi.org/10.1007/978-3-642-57533-4_7
Publisher Name: Steinkopff, Heidelberg
Print ISBN: 978-3-642-63289-1
Online ISBN: 978-3-642-57533-4
eBook Packages: Springer Book Archive