Abstract
Interphase cytogenetics using formalin fixed/paraffin embedded tissue is now a well-established technique, which renders it possible to obtain “cytogenetic information” from interphase nuclei, especially from solid tumors (Hackel and VarellaGarcia, 1997, Wolfe and Herrington, 1997). It is nearly the only tool to investigate specific numerical chromosomal aberrations, amplification of oncogenes (see Figure 1), deletion of tumor suppressor genes or chromosomal translocations in formalin-fixed/paraffin-embedded tumor tissue samples on a single cell level.
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References
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© 2002 Springer-Verlag Berlin Heidelberg
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Liehr, T. (2002). Nucleus Extraction from Formalin Fixed/paraffin Embedded Tissue. In: Rautenstrauss, B.W., Liehr, T. (eds) FISH Technology. Springer Lab Manuals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56404-8_12
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DOI: https://doi.org/10.1007/978-3-642-56404-8_12
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