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Involvement of Heat Shock Protein 70 (Hsp70) in Gastrointestinal Cancers

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HSP70 in Human Diseases and Disorders

Part of the book series: Heat Shock Proteins ((HESP,volume 14))

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Abstract

Intracellular protein homeostasis is largely controlled by Heat shock proteins (Hsp). Heat shock proteins (Hsp) impart an age-old defense mechanism for all forms of life on earth. Misfolded proteins are refolded with the aid of Hsp and proteins which are damaged beyond repair are eliminated with assistance from Hsp. Hsp are known as molecular chaperones for their cytoprotective roles. In cancer cells the Hsp are frequently overexpressed and are assumed to be associated with tumor formation. Hsp demonstrate specific affinity to particular classes of oncogenic peptides and client proteins in cancer cells, and are able to stabilize mutated oncogene proteins. They play a key regulatory role in prevention of apoptotic cell death during tumorigenesis and thereby enhance cell growth and proliferation. They may also promote chemoresistance in cancer cells. Here we present the current knowledge on the role of molecular chaperones in particular heat shock protein 70 (Hsp70) in human gastrointestinal cancers along with their therapeutic targeting. This review will focus on the role of Hsp 70 and related chaperones in several gastrointestinal cancers such as pancreatic, gastric, and liver cancers.

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Abbreviations

α-SMA:

α-smooth muscle actin protein

CHIP:

carboxyl-terminus of Hsp70 interacting Protein

CSC:

cancer stem cells

GC:

gastric cancer

GI:

gastrointestinal

HCC:

hepatocellular carcinoma

HNSCC:

head and neck squamous cell cancer

HOP:

Hsp70/Hsp90 organizing protein

MAPK:

mitogen activated protein kinase

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Acknowledgements

D. Datta acknowledges financial support from Visva-Bharati University.

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  1. Sanghamitra Raha

    Present address: , Kolkata, India

Authors and Affiliations

  1. Department of Biotechnology, Visva-Bharati, Santiniketan, India

    Dipamoy Datta & Sanghamitra Raha

  2. Department of Biological Chemistry, Indian Association for the Cultivation of Science, Kolkata, India

    Suparna Banerjee & Prosenjit Sen

  3. Division of Plant Biology, Bose Institute, Kolkata, India

    Anupama Ghosh

  4. University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    Soumyajit Banerjee Mustafi

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  1. Dipamoy Datta
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  2. Suparna Banerjee
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  3. Anupama Ghosh
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  4. Soumyajit Banerjee Mustafi
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  5. Prosenjit Sen
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  6. Sanghamitra Raha
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Editors and Affiliations

  1. Department of Medicine and Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Punit Kaur

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Datta, D., Banerjee, S., Ghosh, A., Banerjee Mustafi, S., Sen, P., Raha, S. (2018). Involvement of Heat Shock Protein 70 (Hsp70) in Gastrointestinal Cancers. In: Asea, A., Kaur, P. (eds) HSP70 in Human Diseases and Disorders. Heat Shock Proteins, vol 14. Springer, Cham. https://doi.org/10.1007/978-3-319-89551-2_4

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