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Olfactory Neuroblastoma and Sellar Neuroblastoma

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Atlas of Sellar and Parasellar Lesions

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Abstract

Olfactory neuroblastoma (ONB), also referred to as esthesioneuroblastoma, is an uncommonly occurring malignant tumor that arises from the olfactory neuroepithelium of the upper nasal cavity and anterior skull base. Tumors that are large enough may extend posteriorly to the sellar region.

ONB represents 2–6 % of all sinonasal malignancies.

The incidence is 0.4 per million persons.

The age distribution of patients has been reported to be bimodal, in the second and sixth decades of life.

Common clinical symptoms include unilateral nasal obstruction and epistaxis, but may also include anosmia, visual symptoms, facial pain, lacrimation, headache, and rhinorrhea.

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Author information

Authors and Affiliations

  1. Department of Neurological Surgery, Keck School of Medicine, University of Southern California, 1200 N State Street, #3300, Los Angeles, CA, 90033, USA

    Gabriel Zada MD, MS

  2. Department of Pathology (Neuropathology), University of Virginia School of Medicine, 1215 Lee Street, Room 3060–HEP, Charlottesville, VA, 22908, USA

    M. Beatriz S. Lopes MD, PhD

  3. Department of Radiology, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA, 02115, USA

    Srinivasan Mukundan Jr. PhD, MD

  4. Department of Neurosurgery, Brigham and Women’s Hospital, 15 Francis Street, Boston, MA, 02115, USA

    Edward Laws Jr. MD

Authors
  1. Gabriel Zada MD, MS
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  2. M. Beatriz S. Lopes MD, PhD
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  3. Srinivasan Mukundan Jr. PhD, MD
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  4. Edward Laws Jr. MD
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Corresponding author

Correspondence to Gabriel Zada MD, MS .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, University of Southern California, LOS ANGELES, California, USA

    Gabriel Zada

  2. Department of Pathology, University of Virginia, CHARLOTTESVILLE, Virginia, USA

    M. Beatriz S. Lopes

  3. Department of Radiology, Brigham and Women's Hospital, BOSTON, Massachusetts, USA

    Srinivasan Mukundan Jr.

  4. Department of Neurosurgery, Brigham and Women’s Hospital, BOSTON, Massachusetts, USA

    Edward R. Laws Jr.

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© 2016 Springer International Publishing Switzerland

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Zada, G., Lopes, M.B.S., Mukundan, S., Laws, E. (2016). Olfactory Neuroblastoma and Sellar Neuroblastoma. In: Zada, G., Lopes, M., Mukundan Jr., S., Laws Jr., E. (eds) Atlas of Sellar and Parasellar Lesions. Springer, Cham. https://doi.org/10.1007/978-3-319-22855-6_38

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  • DOI: https://doi.org/10.1007/978-3-319-22855-6_38

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-22854-9

  • Online ISBN: 978-3-319-22855-6

  • eBook Packages: MedicineMedicine (R0)

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