Abstract
Rho GTPases serve as the central signaling molecules in the regulation of vital cellular processes such as cell expansion, directional growth, and division. Rho GTPases have an exceptional ability to interact with diverse regulator and effector molecules that eventually confer signaling specificity to them. Three important regulatory factors including GEFs, GAPs, and GDIs have been identified as essential for Rho signaling events. In response to an extracellular stimulus, GEFs control spatiotemporal signaling activity of Rho GTPases. In comparison to GEFs, GAPs and GDIs are largely believed to be of lesser functional significance. However, recent research has established that members of Rho GAPs and Rho GDIs are much more intricate in the regulation of Rho signaling-mediated cellular processes than previously predicted. Rho GAP and Rho GDI gene families are well conserved in eukaryotes. It has been established that in animals, GAPs and GDIs function strictly according to the upstream regulators, and similar regulation has been anticipated for their plant counterparts.
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Pandey, G.K., Sharma, M., Pandey, A., Shanmugam, T. (2015). Functional Genomic Perspective of Small GTPases. In: GTPases. SpringerBriefs in Plant Science. Springer, Cham. https://doi.org/10.1007/978-3-319-11611-2_8
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DOI: https://doi.org/10.1007/978-3-319-11611-2_8
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