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Myogenic Control of Airways Smooth Muscle and Cell-to-Cell Coupling

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Airways Smooth Muscle: Development, and Regulation of Contractility

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

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Abstract

In smooth muscle in general, contraction is the physiologically relevant endpoint and is a Ca2+-dependent event. In addition, many of the ion conductances in smooth muscle are regulated by Ca2+ and/or are permeable to Ca2+. As a prerequisite to this discussion of myogenic contractile and electrical activity in airways smooth muscle (ASM), then, it is necessary to review briefly the regulation of contractile activity and of Ca2+-homeostasis in smooth muscle. Many of these issues will be dealt with in more detail in subsequent chapters and volumes of this series.

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Authors and Affiliations

  1. Departments of Medicine, McMaster University, Hamilton, Ontario, Canada

    Luke Janssen & Ed E. Daniel

  2. Departments of Biomedical Science, McMaster University, Hamilton, Ontario, Canada

    Ed E. Daniel

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  1. Luke Janssen
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  1. Discovery Biology, RhĂ´ne-Poulenc Rorer Ltd, Dagenham Research Centre, RM10 7XS, Dagenham, Essex, England

    David Raeburn (Department Head) (Department Head)

  2. Department of Thoracic Medicine, Royal Brompton National Heart and Lung Institute, Dovehouse Street, SW3 6LY, London, England

    Mark A. Giembycz (Lecturer) (Lecturer)

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Janssen, L., Daniel, E.E. (1994). Myogenic Control of Airways Smooth Muscle and Cell-to-Cell Coupling. In: Raeburn, D., Giembycz, M.A. (eds) Airways Smooth Muscle: Development, and Regulation of Contractility. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7408-3_4

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  • DOI: https://doi.org/10.1007/978-3-0348-7408-3_4

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