Abstract
Small-molecule drugs are a cost-effective way to treat and prevent disease. A study by the Slone Institute published in 2002 estimated that over 50% of the adult population in the United States used at least one pharmaceutical drug during the preceding week. The positive impact of small-molecule drugs on health care has been well documented (1,2).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Lichtenberg, F. R. (2003) The economic and human impact of new drugs. J. Clin. Psychiatry 64 (Suppl 17), 15–18.
Hansen, R. W. (1986) New pharmaceuticals reduce cost of illness. Can. Pharm. J. 119 (6), 318–325.
Goodman, L. S., Hardman, J., and Limbird, L. (eds.). Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 9th ed. McGraw-Hill, New York.
Fleischmann, R. D., Adams, M. D., White, O., et al. (1995) Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 269 (5223), 496–512.
Stockwell, B. R., Haggarty, S. J., and Schreiber, S. L. (1999) High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications. Chem. Biol. 6 (2), 71–83.
Spring, D. R., Krishnan, S., Blackwell, H. E., and Schreiber, S. L. (2002) Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform. J. Am. Chem. Soc. 124 (7), 1354–1363.
Haggarty, S. J., Koeller, K. M., Wong, J. C., Butcher, R. A., and Schreiber, S. L. (2003) Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays. Chem. Biol. 10(5), 383–396.
Shogren-Knaak, M. A., Alaimo, P. J., and Shokat, K. M. (2001) Recent advances in chemical approaches to the study of biological systems. Annu. Rev. Cell Dev. Biol. 17, 405–433.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Humana Press Inc.
About this protocol
Cite this protocol
Caron, P.R. (2005). Introduction to Chemical Genomics. In: Zanders, E.D. (eds) Chemical Genomics. Methods in Molecular Biology™, vol 310. Humana Press. https://doi.org/10.1007/978-1-59259-948-6_1
Download citation
DOI: https://doi.org/10.1007/978-1-59259-948-6_1
Publisher Name: Humana Press
Print ISBN: 978-1-58829-399-2
Online ISBN: 978-1-59259-948-6
eBook Packages: Springer Protocols