Abstract
The role of neuroscience intensive care in the patient with traumatic brain injury (TBI) has advanced rapidly over the past few decades. Injury induced by trauma is not limited to vascular distributions of the brain or anatomically discrete regions. As our understanding of the biochemical and pathophysiologic mechanisms of ischemia, seizure, and neurodegenerative disease has evolved so has our recognition that the mechanism of damage in TBI probably encapsulates similar cellular mechanisms of injury. The penumbra at risk for secondary injury in severe TBI is often larger than a vascular distribution and the course more progressive, requiring rapid and often multiple levels of acute neurosurgical and neurologic care. With the advent of neuroscience critical care units (NSUs), these needs are being systematically addressed. In this chapter we will review the primary aspects of TBI, including its epidemiology, mechanisms of injury, early management, monitoring, and prognosis.
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References
Sosin DM, Sniezek JE, Thurman DJ. Incidence of mild and moderate brain injury in the United States, 1991. Brain Injury 1996; 10: 47–54.
Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. Unpublished analysis of data from the 1994 National Hospital Discharge Survey, 1998.
Sosin DM, Sniezek JE, Waxweiler RJ. Trends in death associated with traumatic brain injury, 1979 through 1992. JAMA 1995; 273: 1778–1780.
Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. Unpublished analysis of data from Multiple Cause of Death Public Use Data, 1997.
Max W, MacKenzie EJ, Rice DP. Head injuries: costs and consequences. J. Head Trauma Rehabil. 1991; 6: 76–91.
Tremolada C, Candiani P, Signorini M, Vigano M, Donati L. The surgical anatomy of the subcutaneous fascial system of the scalp. Ann. Plast. Surg. 1994; 32: 8–14.
Braakman R. Depressed skull fracture: Data, treatment, and follow-up in 225 consecutive cases. J. Neurol. Neurosurg. Psychiatry 1972; 35: 395–402.
Brawley B W, Kelly WA. Treatment of basal skull fractures with and without cerebrospinal fluid fistulae. J. Neurosurg. 1967; 26: 57–61.
Fransen P, Sindic CJ, Thauvoy C, Laterre C, Stroobandt G. Highly sensitive detection of beta-2 transferrin in rhinorrhea and otorrhea as a marker for cerebrospinal fluid (C.S.F.) leakage. Acta Neurochir. (Wien) 1991; 109: 98–101.
Einhorn A, Mizrahi EM. Basilar skull fractures in children. The incidence of CNS infection and the use of antibiotics. Am. J. Dis. Child. 1978; 132: 1121–1124.
Ford LE, McLaurin RL. Mechanisms of extradural hematomas. J. Neurosurg. 1963; 20: 760–769.
Ganz JC, Zwetnow NN. Analysis of the dynamics of experimental epidural bleeding in swine. Acta. Neurochir. (Wien) 1988; 95: 72–81.
Piepmeier JM, Wagner FC Jr. Delayed post-traumatic extracerebral hematomas. J. Trauma 1982; 22: 455–460.
Stone JL, Rifai MH, Sugar O, Lang RG, Oldershaw JB, Moody RA. Subdural hematomas. I. Acute subdural hematoma: Progress in definition, clinical pathology, and therapy. Surg. Neurol. 1983; 19: 216–231.
Servadei F. Prognostic factors in severely head injured adult patients with acute subdural haematomas. Acta Neurochir. 1997; 139: 279–285.
Jamieson KG, Yelland JD.Traumatic intracerebral hematoma. Report of 63 surgically treated cases. J. Neurosurg. 1972; 37: 528–532.
Baratham G, Dennyson WG. Delayed traumatic intracerebral haemorrhage. J. Neurol. Neurosurg. Psychiatry 1972; 35: 698–706.
Alvarez-Sabin J, Turon A, Lozano-Sanchez M, Vazquez J, Codina A. Delayed posttraumatic hemorrhage. “Spat-apoplexie.” Stroke 1995; 26: 1531–1535.
Lindenberg R, Freytag E. The mechanism of cerebral contusions: A pathologic-anatomic study. Arch. Pathol. 1960; 69: 440–469.
Dublin AB, French BN, Rennick JM. Computed tomography in head trauma. Radiology 1977; 122: 365–369.
Hesselink JR, Dowd CF, Healy ME, Hajek P, Baker LL, Luerssen TG. MR imaging of brain contusions: A comparative study with CT. AJR 1988; 150: 1133–1142.
Gurdjian ES. Cerebral contusions: re-evaluation of the mechanism of their development. J. Trauma 1976; 16: 35–51.
Schonauer M, Schisano G, Cimino R, Viola L. Space occupying contusions of cerebral lobes after closed brain injury: considerations about 51 cases. J. Neurosurg. Sci. 1979; 23: 279–288.
Misra JC, Chakravarty S. A study of rotational brain injury. J. Biomech. 1984; 17: 459–466.
Report of the ad hoc committee to study head injury nomenclature: Proceedings of the Congress of Neurological Surgeons in 1964. Clin. Neurosurg. 1966; 12: 386–394.
Fitzpatrick MO, Dewar D, Teasdale GM, Graham DI. The neuronal cytoskeleton: An insight for neurosurgeons. Br. J. Neurosurg. 1996; 10: 483–487.
Yamaki T, Murakami N, Iwamoto Y, et al. Pathological study of diffuse axonal injury patients who died shortly after impact. Acta Neurochir. 1992; 119: 153–158.
Bouma GJ, Muizelaar JP, Choi SC, Newlon PG, Young HF. Cerebral circulation and metabolism after severe traumatic brain injury: the elusive role of ischemia. J. Neurosurg. 1991; 75: 685–693.
DeSalles AA, Kontos HA, Becker DP, et al. Prognostic significance of ventricular CSF lactic acidosis in severe head injury. J. Neurosurg. 1986; 65: 615–624.
Obrist WD, Langfitt TW, Jaggi JL, Cruz J, Gennarelli TA. Cerebral blood flow and metabolism in comatose patients with acute head injury. Relationship to intracranial hypertension. J. Neurosurg. 1984; 61: 241–253.
Langfitt TW, Marshall WJ, Kassell NF, Schutta HS. The pathophysiology of brain swelling produced by mechanical trauma and hypertension. Scand. J. Clin. Lab. Invest. Suppl. 1968;102:XIV:B.
Muizelaar JP, Ward JD, Marmarou A, Newlon PG, Wachi A. Cerebral blood flow and metabolism in severely head-injured children. Part 2: Autoregulation. Neurosurgery 1989; 71: 72–76.
Lee SM, Wong MD, Samii A, Hovda DA. Evidence for energy failure following irreversible traumatic brain injury. Ann. NY Acad. Sci. 1999; 893: 337–340
Goodman JC, Valadka AB, Gopinath SP, Uzura M, Robertson CS. Extracellular lactate and glucose alterations in the brain after head injury measured by microdialysis. Crit. Care Med. 1999; 27: 1965–1973.
Reinert M, Hoelper B, Doppenberg E, Zauner A, Bullock R. Substrate delivery and ionic balance disturbance after severe human head injury. Acta. Neurochir. Suppl. 2000; 76: 439–444.
Hovda DA, Becker DP, Katayama Y. Secondary injury and acidosis. J. Neurotrauma 1992;9 Suppl 1:S47–S60.
Palmer AM, Marion DW, Botscheller ML, Bowen DM, DeKosky ST. Increased transmitter amino acid concentration in human ventricular CSF after brain trauma. Neuroreport 1994; 6: 153–156.
Hong Z, Xinding Z, Tianlin Z, Liren C. Excitatory amino acids in cerebrospinal fluid of patients with acute head injuries. Clin. Chem. 2001; 47: 1458–1462.
Obrenovitch TP, Urenjak J. Is high extracellular glutamate the key to excitotoxicity in traumatic brain injury? J. Neurotrauma 1997; 14: 677–698.
Allan SM. The role of pro-and antiinflammatory cytokines in neurodegeneration. Ann. NY Acad. Sci. 2000; 917: 84–93.
Quattrocchi KB, Frank EH, Miller CH, et al. Suppression of cellular immune activity following severe head injury. J. Neurotrauma 1990; 7: 77–87.
Wolach B, Sazbon L, Gavrieli R, Broda A, Schlesinger M. Early immunological defects in comatose patients after acute brain injury. J. Neurosurg. 2001; 94: 706–711.
Aibiki M, Maekawa S, Ogura S, Kinoshita Y, Kawai N, Yokono S. Effect of moderate hypothermia on systemic and internal jugular plasma IL-6 levels after traumatic brain injury in humans. J. Neurotrauma 1999; 16: 225–232.
Csuka E, Morganti-Kossmann MC, Lenzlinger PM, Joller H, Trentz O, Kossmann T. IL-10 levels in cerebrospinal fluid and serum of patients with severe traumatic brain injury: Relationship to IL-6, TNF-alpha, TGF-beta1 and blood-brain barrier function. J. Neuroimmunol. 1999; 101: 211–221.
Kossmann T, Stahel PF, Lenzlinger PM, et al. Interleukin-8 released into the cerebrospinal fluid after brain injury is associated with blood-brain barrier dysfunction and nerve growth factor production. J. Cereb. Blood Flow Metab. 1997; 17: 280–289.
McKeating EG, Andrews PJ, Mascia A. The relationship of soluble adhesion molecule concentrations in systemic and jugular venous serum to injury severity and outcome after traumatic brain injury. Anesth. Analg. 1998; 86: 759–765.
Zemlan FP, Rosenberg WS, Luebbe PA, et al. Quantification of axonal damage in traumatic brain injury: Affinity purification and characterization of cerebrospinal fluid tau proteins. J. Neurochem. 1999; 72: 741–750.
Raby CA, Morganti-Kossmann MC, Kossmann T, et al. Altered expression of amyloid precursors proteins after traumatic brain injury in rats: in situ hybridization and immunohistochemical study. J. Neurotrauma 2000; 17: 123–134.
Spiegel K, Kuo YM, Roher AE, Emmerling MR. Traumatic brain injury increases beta-amyloid peptide 1–42 in cerebrospinal fluid. J. Neurochem. 1998; 71: 2505–2509.
Murray GD, Teasdale GM, Braakman R, et al. On behalf of the European Brain Injury Consortium The European Brain Injury Consortium survey of head injuries. Acta. Neurochir. (Wien.) 1999; 141: 223–236.
Sakas DE, Bullock MR, Teasdale GM. One-year outcome following craniotomy for traumatic hematoma in patients with fixed dilated pupils. J. Neurosurg. 1995; 82: 961–965.
Teasdale G, Jennett B. Assessment of coma and impaired consciousness: A practical scale. Lancet 1974; 2: 81–84.
Gale JL, Dikmen S, Wyler A, Temkin N, McLean A. Head injury in the Pacific Northwest. Neurosurgery 1983; 12: 487–491.
White RJ, Likavec MJ. The diagnosis and initial management of head injury. N. Engl. J. Med. 1992; 327: 1507–1511.
Mazzeo AJ. Sedation for the mechanically ventilated patient. Crit. Care Clin. 1995; 11: 937–955.
Durbin CG Jr. Sedation of the agitated, critically ill patient without an artificial airway. Crit. Care Clin. 1995; 11: 913–936.
Angelini G, Ketzler JT, Coursin DB. Use of propofol and other nonbenzodiazepine sedatives in the intensive care unit. Crit Care Clin. 2001; 17: 863–880.
Robertson CS, Cormio M. Cerebral metabolic management. New Horiz. 1995; 3: 410–422.
Sheinberg M, Kanter MJ, Robertson CS, Contant CF, Narayan RK, Grossman RG Continuous monitoring of jugular venous oxygen saturation in head-injured patients. J. Neurosurg. 1992; 76: 212–217.
Robertson CS, Gopinath SP, Goodman JC, Contant CF, Valadka AB, Narayan RK. SjvO2 monitoring in head-injured patients. J. Neurotrauma 1995; 12: 891–896.
Cruz J, Minoja G, Mattioli C, et al. Severe acute brain trauma. In: Cruz J, ed. Neurologic and Neurosurgical Emergencies. Philadelphia: WB Saunders, 1998, pp. 405–436.
Chesnut RM. Secondary brain insults after head injury: Clinical perspectives. New Horiz. 1995; 3: 366–375.
Liebert M. Hypotension. J. Neurotrauma 2000; 17: 591–595.
Contant CF, Valadka AB, Gopinath SP, Hannay HJ, Robertson CS. Adult respiratory distress syndrome: a complication of induced hypertension after severe head injury. J. Neurosurg. 2001; 95: 560–568.
Robertson CS, Valadka AB, Hannay HJ, et al. Prevention of secondary ischemic insults after severe head injury. Crit. Care Med. 1999; 27: 2086–2095.
Feldman Z, Kanter MJ, Robertson CS, et al. Effect of head elevation on intracranial pressure, cerebral perfusion pressure, and cerebral blood flow in head-injured patients. J. Neurosurg. 1992; 76: 207–211.
Bullock R. Mannitol and other diuretics in severe neurotrauma. New Horiz. 1995; 3: 448–452.
Miller JD, Piper IR, Dearden NM. Management of intracranial hypertension in head injury: matching treatment with cause. Acta Neurochir. Suppl 1993; 57: 152–159.
Qureshi AI, Suarez JI. Use of hypertonic saline solutions in treatment of cerebral edema and intracranial hypertension. Crit. Care Med. 2000; 28: 3301–3313.
Suarez JI, Qureshi AI, Bhardwaj A, et al. Treatment of refractory intracranial hypertension with 23.4% saline. Crit. Care Med. 1998; 26: 1118–1122.
The Brain Trauma Foundation. The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care. Hyperventilation. J. Neurotrauma 2000; 17: 513–520.
Diringer MN, Videen TO, Yundt K, et al. Regional cerebrovascular and metabolic effects of hyperventilation after severe traumatic brain injury. J. Neurosurg. 2002; 96: 103–108.
Kassell NF, Hitchon PW, Gerk MK, Sokoll MD, Hill TR. Alterations in cerebral blood flow, oxygen metabolism, and electrical activity produced by high dose sodium thiopental. Neurosurgery 1980; 7: 598–603.
Rea GL, Rockswold GL. Barbiturate therapy in uncontrolled intracranial hypertension. Neurosurgery 1983; 12: 401–404.
Roberts I, Schierhout G, Alderson P, Absence of evidence for the effectiveness of five interventions routinely used in the intensive care management of severe head injury: A systematic review. J. Neurol. Neurosurg. Psychiatry 1998; 65: 729–733.
De Luca GP, Volpin L, Fornezza U, et al. The role of decompressive craniectomy in the treatment of uncontrollable post-traumatic intracranial hypertension. Acta Neurochir. Suppl 2000; 76: 401–404.
Meier U, Zeilinger FS, Henzka O. The use of decompressive craniectomy for the management of severe head injuries. Acta Neurochir. Suppl 2000; 76: 475–478.
Munch E, Horn P, Schurer L, Piepgras A, Paul T, Schmiedek P. Management of severe traumatic brain injury by decompressive craniectomy. Neurosurgery 2000; 47: 315–322.
Coplin WM, Cullen NK, Policherla PN, et al. Safety and feasibility of craniectomy with duraplasty as the initial surgical intervention for severe traumatic brain injury. Trauma 2001; 50: 1050–1059.
Rovlias A, Kotsou S. The influence of hyperglycemia on neurological outcome in patients with severe head injury. Neurosurgery 2000; 46: 335–342.
Lam AM, Winn HR, Cullen BF, Sundling N. Hyperglycemia and neurological outcome in patients with head injury. J. Neurosurg. 1991; 75: 545–551.
Vespa PM, Nuwer MR, Nenov V, et al. Increased incidence and impact of nonconvulsive and convulsive seizures after traumatic brain injury as detected by continuous electroencephalographic monitoring. J. Neurosurg. 1999; 91: 750–760.
The Brain Trauma Foundation. The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care. Role of antiseizure prophylaxis following head injury. J. Neurotrauma 2000; 17: 549–553.
Annegers JF, Hauser WA, Coan SP, Rocca WA. A population-based study of seizures after traumatic brain injuries. N. Engl. J. Med. 1998; 338: 20–24.
Markgraf CG, Clifton GL, Moody MR. Treatment window for hypothermia in brain injury. J. Neurosurg. 2001 95: 979–983.
Clifton GL, Choi SC, Miller ER, et al. Intercenter variance in clinical trials of head trauma—experience of the National Acute Brain Injury Study: Hypothermia. J. Neurosurg. 2001; 95: 751–755.
Clifton GL, Miller ER, Choi SC, et al. Lack of effect of induction of hypothermia after acute brain injury. N. Engl. J. Med. 2001 344: 556–563.
Kamran SI, Downey D, Ruff RL.Pneumatic sequential compression reduces the risk of deep vein thrombosis in stroke patients. Neurology 1998; 50: 1683–1688.
Taylor SJ, Fettes SB, Jewkes C, Nelson RJ. Prospective, randomized, controlled trial to determine the effect of early enhanced enteral nutrition on clinical outcome in mechanically ventilated patients suffering head injury. Crit. Care Med. 1999; 27: 2525–2531.
Yanagawa T, Bunn F, Roberts I, Wentz R, Pierro A. Nutritional support for head-injured patients. Cochrane Database Syst. Rev. 2000;2:CD001530.
The Brain Trauma Foundation. The American Association of Neurological Surgeons. The Joint section on Neutrotrauma and Critical Care. Nutrition. J. Neurotrauma 2000; 17: 539–547.
Pepe JL, Barba CA. The metabolic response to acute traumatic brain injury and implications for nutritional support. J. Head Trauma Rehabil. 1999; 14: 462–474.
Zubkov AY, Pilkington AS, Parent AD, Zhang J. Morphological presentation of posttraumatic vasospasm. Acta Neurochir. Suppl 2000; 76: 223–236.
Kaspera W, Majchrzak H, Zientek A. Dynamics of cerebral circulation on the basis of transcranial Doppler ultrasonography evaluation in patients with moderate and minor head injury. Neurol. Neurochir. Pol. 2001; 35: 261–279.
Langham J, Goldfrad C, Teasdale G, Shaw D, Rowan K. Calcium channel blockers for acute traumatic brain injury. Cochrane Database Syst. Rev. 2000;2:CD000565.
Peter B. Letarte, Neurotrauma care in the new millennium. Surg. Clin. North Am. 1999; 79: 1449–1455.
The Brain Trauma Foundation. The American association of neurological surgeons. The Joint Section on Neurotrauma and Critical Care. Age. J. Neurotrauma 2000; 17: 573–581.
Lannoo E, Van Rietvelde F, et al. Early predictors of mortality and morbidity after severe closed head injury. J. Neurotrauma 2000; 17: 403–414.
Ghajar J. Traumatic brain injury. Lancet 2000; 356: 923–929.
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Kuniyoshi, S., Suarez, J.I. (2004). Traumatic Head Injury. In: Suarez, J.I. (eds) Critical Care Neurology and Neurosurgery. Current Clinical Neurology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-660-7_22
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