Abstract
Most receptors for biologically active molecules are found upon the cell surface. They recognize their appropriate ligands and bind them. This binding leads to a change in receptor conformation and thence to intracellular signals and responses. In some cases (hormone receptors), the sequence is of chemical activation through to a chemically mediated biological response, which may involve alterations in the electrical potential of the target cell.
In the case of neurotransmitters the situation is slightly more complicated: A wave of depolarization passes down a nerve process (axon), causes the release of the appropriate chemical messenger that binds to a receptor, and may produce either an immediate (electrical) or a longer-term (chemical through to morphological) response.
Cell surface receptors are many and varied. I shall describe only a few. In the case of those receptors that I describe, I shall comment upon their intracellular linkages and give my views about the relationship between their intracellular messengers and those that are induced by chemical messengers that act upon the genome.
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Thomas, P.J. (1988). Membrane Receptors. In: Franks, F. (eds) Characterization of Proteins. Biological Methods. Humana Press. https://doi.org/10.1007/978-1-59259-437-5_8
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DOI: https://doi.org/10.1007/978-1-59259-437-5_8
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